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Links from GEO DataSets

Items: 20

1.

Identifying lncRNAs as novel modulators of macrophage M2 polarization

(Submitter supplied) By utilizing a series of specific modulating M2 macrophages polarization models, 3872 up-regulated and 3091 down-regulated genes were found during the polarization process.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL24378
2 Samples
Download data: GPR
Series
Accession:
GSE107979
ID:
200107979
2.

Identifying lncRNA-MM2P as a novel modulator of macrophage M2 polarization

(Submitter supplied) By utilizing a series of specific modulating M2 macrophages polarization models, 1556 up-regulated and 953 down-regulated genes were found during the polarization process.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL24373
4 Samples
Download data: GPR
Series
Accession:
GSE107952
ID:
200107952
3.

Identification of differentially expressed lncRNAs in CpG ODN-activated macrophage

(Submitter supplied) The innate immune system is the first line of defense against microbial pathogens. The activated innate immune system plays important roles in eliciting antimicrobial defenses. Despite the benefits of innate immune responses, excessive inflammation will cause host damage. Thus, tight regulation of these processes is required for the maintenance of immune homeostasis. Recently, a new class of long non-coding RNAs (lncRNAs) has emerged as important regulators in many physiological and pathological processes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL22782
4 Samples
Download data: TXT
Series
Accession:
GSE120417
ID:
200120417
4.

lncRNA expression profiles from murine BALB/c macrophages at the extremes of the M(LPS+IFN-γ) and M(IL-4) polarized phenotypes

(Submitter supplied) Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M(LPS+IFN-γ) and M(IL-4) polarized phenotypes. The aim of the present study was to screen for differentially lncRNAs that were associated with macrophage polarization. The lncRNA profiles of three M(LPS+IFN-γ) and three M(IL-4) samples were obtained using microarray analysis. Based on the threshold of fold-change >2.0 and a p-value < 0.05, we screened a total of 1,251 lncRNAs, of which 627 were upregulated and 624 downregulated in M(LPS+IFN-γ) macrophages compared to that in M(IL-4) macrophages.This study provides new insights into the role of genes in macrophage differentiation and polarization.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL20939
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE125510
ID:
200125510
5.

Gene expression profiling of mouse macrophages following long noncoding RNA Malat1 knockdown

(Submitter supplied) We applied next-generation sequencing to investigate the gene expression profiles in mouse bone-marrow derived macrophages with or without long noncoding RNA-Malat1 knockdown. We identified a number of differentially regulated genes in cells with Malat1 knockdown.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TXT
Series
Accession:
GSE106913
ID:
200106913
6.

Stat6 occupancy profiling by high throughput sequencing from wild-type(WT) or Trim24-deficient(Trim24-KO) mouse peritoneal macrophages stimulated with IL-4 for 1 hour .

(Submitter supplied) To identify the potential genes that regulated by Trim24 through Stat6 DNA binding activity, we immunoprecipitated chromatin from WT or Trim24-KO macrophages stimulated with IL-4, and analyzed the precipitated DNA with deep sequencing (ChIP-Seq).
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
3 Samples
Download data: BW
Series
Accession:
GSE134167
ID:
200134167
7.

Expression data from wild-type and TIF1a-knockout mouse macrophages stimulated with or without mouse IL-4(20ng/mL) for 6 h.

(Submitter supplied) We conducted gene expression profile analysis by using wild-type and TIF1a-knockout peritoneal macrophage.Analysis revealed the most prominent different expression of genes altered in macrophages upon IL-4 stimulation were associated with marker genes of alternative macrophage.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: XLS
Series
Accession:
GSE134158
ID:
200134158
8.

Expression data from wild-type peritoneal macrophages (termed WTPM) non-treated (NT) or stimulated for 6 h with mouse IL-4.

(Submitter supplied) We conducted gene expression profile analysis by using wild-type peritoneal macrophages(termed WTPM).Scatter diagram revealed the most prominent different expression of genes altered in macrophages upon IL-4 stimulation were associated with M2 macrophage and Trims genes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: XLS
Series
Accession:
GSE116588
ID:
200116588
9.

Expression data from WT and Trim24-deficient tumor-associated macrophage(TAM) sorted from B16 bearing mouse

(Submitter supplied) We conducted gene expression profile analysis by using CD45+ CD11b+ F4/80+ TAM sorted from WT or Trim24-deficient B16 bearing mouse.Scatter diagram revealed the most prominent different expression of genes altered in TAM were associated with M2 genes.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: TXT
Series
Accession:
GSE116566
ID:
200116566
10.

Intracellular Cryptococcus neoformans Disrupts the Transcriptome Profile of M1- and M2-Polarized Host Macrophages

(Submitter supplied) Macrophages serve as a first line of defense against infection with the facultative intracellular pathogen, Cryptococcus neoformans (Cn). However, the ability of these innate phagocytic cells to destroy ingested Cn is strongly influenced by polarization state with classically (M1) activated macrophages better able to control cryptococcal infections than alternatively (M2) activated cells. While earlier studies have demonstrated that intracellular Cn minimally affects the expression of M1 and M2 markers, the impact on the broader transcriptome associated with these states remains unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
15 Samples
Download data: TXT, XLSX
Series
Accession:
GSE150802
ID:
200150802
11.

Trajectory analysis quantifies transcriptional plasticity during macrophage polarization

(Submitter supplied) Ctyokine-stimulated polarization and repolarization of murine bone marrow-derived macrophages (LPS + IFNγ, IL-4); bulk RNA-seq timecourse and bulk ATAC-seq for selected timepoints and conditions
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
161 Samples
Download data: CSV, MTX, TSV, TXT
Series
Accession:
GSE158094
ID:
200158094
12.

Genomic expression analysis of K562 cells expressing shRNA targeting lncRNA-IIRX and control cells

(Submitter supplied) LncRNA-IIRX plays critical role in Bcr-Abl-induced tumorigenesis. To discover its mechanisms underlying cellular transformation by Bcr-Abl oncogene, genome-wide mRNA expression was measured by RNA-seq in K562 cells expressing shRNA targeting lncRNA-IIRX and control cells. We identified many genes with differential expression in K562 cells after knocking down lncRNA-IIRX.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE120337
ID:
200120337
13.

Identification of a novel lncRNA family that is required for efficient cellular transformation by Bcr-Abl oncogene

(Submitter supplied) Aberrantly expressed long noncoding RNAs (lncRNAs) have been described in diverse human diseases and cancer development. Chronic myeloid leukemia (CML) is a hematological malignancy induced by Bcr-Abl hybrid gene. Owing to the development of tyrosine kinase inhibitors (TKIs), especially the first-generation Imatinib, over 90% of CML patients can be cured in recent years. Here we attempt to identify Imatinib-inducible lncRNAs associated with CML by analyzing lncRNA expression profiles in K562 cells after Imatinib or control treatment. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL21096
6 Samples
Download data: TXT, XLSX
Series
Accession:
GSE119770
ID:
200119770
14.

Differentiation of lncRNAs expression during the polarization macrophages

(Submitter supplied) To determine lncRNAs transcribed during the polarization of macrophages, we have employed whole genome microarray expression profiling as a discovery platform to identify lncRNAs expression in mouse primary bone marrow derived macrophages (BMDMs) treated with M1 (lipopolysaccharide, LPS) and M2 (IL-4) stimulators.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL21035
9 Samples
Download data: TXT
Series
Accession:
GSE122150
ID:
200122150
15.

Gene expression profile of peroxisome proliferator-activated receptor delta (Ppard)-overexpressing RAW 264.7 macrophages treated vehicle, GW501516 or interleukin-4 (Il-4)

(Submitter supplied) Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle. Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10192
9 Samples
Download data: PAIR
Series
Accession:
GSE100237
ID:
200100237
16.

Gene expression profiles from murine BALB/c macrophages at the extremes of the M1 and M2 polarized phenotypes

(Submitter supplied) Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M1 and M2 polarized phenotypes. The aim of the present study was to screen for differentially expressed genes (DEGs) that were associated with macrophage polarization. The transcription profiles of three M1 and three M2 samples were obtained using microarray analysis. Based on the threshold of fold-change >2.0 and a p-value < 0.05, we screened a total of 1,253 DEGs, of which 696 were upregulated and 557 downregulated in M1 macrophages compared to that in M2 macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20939
6 Samples
Download data: TXT
Series
Accession:
GSE81922
ID:
200081922
17.

Transcript dynamics in classically and alternatively activated macrophages

(Submitter supplied) Using RNA-seq, we have reported that signaling crosstalk among IFN-γ and LPS is integrated at the level of transcriptome and have associated with TFs and TcoFs changes. In addition, we also argue that the transcriptional differences between BMDMs and RAW264.7 macrophage cell line as well as IL-4 and IL-13 on M2 macrophages activation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
25 Samples
Download data: TAB
Series
Accession:
GSE103958
ID:
200103958
18.

Expression Data from Macrophage Maturation and Polarization Experiment

(Submitter supplied) Monocytes were induced to mature to macrophages with M-CSF. Cells were then activated with Interferon gamma and LPS or IL-4.
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2429 GDS2430
Platforms:
GPL97 GPL96
30 Samples
Download data: CEL
Series
Accession:
GSE5099
ID:
200005099
19.
Full record GDS2430

Monocyte differentiation to macrophage and subsequent polarization (HG-U133B)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL97
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2430
ID:
2430
20.
Full record GDS2429

Monocyte differentiation to macrophage and subsequent polarization (HG-U133A)

Analysis of monocytes (MCs) treated with M-CSF to induce differentiation into macrophages (MPs), and mature MPs treated with either IFN-gamma and LPS or IL-4 to induce polarization to M1 or M2 cells, respectively. Results provide insight into MC to MP differentiation and polarized activation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 development stage sets
Platform:
GPL96
Series:
GSE5099
15 Samples
Download data: CEL
DataSet
Accession:
GDS2429
ID:
2429
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