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Links from GEO DataSets

Items: 16

1.

Transcriptome analysis of lung epithelial cells from various developmental stages (E13.5, E15.5, E18.5, P14, and P56)

(Submitter supplied) We investigated whether cell transplantation potential differs between the different developmental stages of the lungs. We found that epithelial cells derived from different developmental stages show different engraftment potential. To identify transcriptional signatures of epithelial cells that are associated with the phenomenon, we performed a time series transcriptome analysis of epithelial cells of the developing lungs.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
7 Samples
Download data: TXT
Series
Accession:
GSE109847
ID:
200109847
2.

Transcriptome analysis of lung epithelial cells and lung fibroblasts from various developmental stages (E18.5, P0.5, P2, P7, P28, and P56)

(Submitter supplied) In the alveoli, lung fibroblasts are in close contact with alveolar epithelial cells type 2, and are considered to support alveolar epithelial cells, forming an alveolar stem cell niche. However, what fibroblast-to-epithelial cell interactions occur during the alveolar maturation stage remains unclear. To understand the lung fibroblast-to-epithelial cell interactions, we performed time-course 3´SAGE-seq analysis of lung epithelial cells and fibroblasts.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18635
21 Samples
Download data: TXT
Series
Accession:
GSE113160
ID:
200113160
3.

Transcriptome analysis of cultured human alveolar epithelial type 2 cells

(Submitter supplied) We investigated whether in vitro expansion of human alveolar epithelial type II cells is possible. We found that human endogenous human alveolar epithelial type II cells can be cultured and passaged. The culture system enabled retroviral gene transduction into human alveolar epithelial type II cells. We performed RNA sequencing of human alveolar epithelial type II cells transduced with mutant surfactant protein C or control vector.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23934
6 Samples
Download data: TXT
Series
Accession:
GSE128291
ID:
200128291
4.

Generation of mature lung alveolar epithelial cells from human pluripotent stem cells

(Submitter supplied) We perform time-series global transcriptomic profiling of a directed differentiation protocol for generating alveolar epithelial type II cells (AEC2s) from pluripotent stem cells (PSCs). We analyzed 3 different timepoints in the RUES2 differentiation: 1) Day 0 undifferentiated cells, 2) Day 15 lung progenitors highly enriched in NKX2-1+ cells by CD47hi/CD26lo sorting, and 3) the outgrowth of these purified progenitors in 3D culture sorted again on Day 35 based on SFTPCtdTomato+ and SFTPCtdTomato- gating. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
21 Samples
Download data: CSV
Series
Accession:
GSE96642
ID:
200096642
5.

Gene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke

(Submitter supplied) Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
12 Samples
Download data: TXT
Series
Accession:
GSE33512
ID:
200033512
6.

Mesenchymal stromal cells isolated from bronchoalveolar lavage and digest parenchymal lung tissue

(Submitter supplied) Stromal support is critical to the achievement of lung homeostasis and the maintenance of an effective epithelial barrier, and yet previous studies have found a positive association between the number of mesenchymal stromal cell populations (MSCs) isolated from the alveolar space and human diseases associated with epithelial dysfunctional. We hypothesised that alveolar MSCs (A-MSCs) represent a dysfunctional population which would be distinct from lung tissue MSCs (LT-MSCs) and which would not be recoverable from healthy humans. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14951
36 Samples
Download data: TXT
Series
Accession:
GSE74284
ID:
200074284
7.

Mesenchymal Nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation

(Submitter supplied) We generated Nfibf/f mice and then cross with Dermo1-Cre mice to obtain Nfibf/f, Dermo1-Cre mice. In these Nfibf/f, Dermo1-Cre mice, there are defects in sacculation and epithelial cell differentiation. We performed micoarray analysis to find the genes which are possibley regulated by NFI-B and related to lung maturation during lung development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE24465
ID:
200024465
8.

Next Generation Sequencing Analysis of human embryonic stem cells derived MESP1-mTomato reporter cells

(Submitter supplied) Purpose: To compare the transcriptome of MESP1-mTomato reporter cells at undifferentiated state, mesoderm differentiation day 3 mTomato+ and mTomato- cells and MESP1+ cells undergoing endothelial differentiation in 2D and 3D. Methods: total RNA from sorted MESP1+, MESP1- and hESCs (in biological duplicates) was extracted using RNeasy Plus Mini Kit (Qiagen) and treated with RNase free DNase. Libraries prepared following the instruction of TruSeq™ RNA Sample Preparation kit (Illumina) and sequenced on Illumina HiSeq 2000. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
10 Samples
Download data: TXT
Series
Accession:
GSE79470
ID:
200079470
9.

Transcriptome in alveolar epithelial progenitor cells isolated from adult human lung

(Submitter supplied) Resident stem/progenitor cells in the lung are important for tissue homeostasis and repair. However, a progenitor population for alveolar type II (ATII) cells in adult human lungs have not been identified. Here we isolated alveolar epithelial progenitor cells (AEPCs) from adult human lungs. AEPCs showed mesenchymal stem cell (MSC)-like characteristics combined with ATII cell-phenotypes. AEPCs had the capability for self-renewal and the potential to generate ATII cells in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL, CHP
Series
Accession:
GSE21095
ID:
200021095
10.

Inhibition of LTβR-signalling blocks epithelial apoptosis and activates endogenous Wnt-induced regeneration

(Submitter supplied) Lymphotoxin β-receptor-signalling orchestrates lymphoid neogenesis and subsequent tertiary lymphoid structures (TLS) associated with severe chronic inflammatory diseases spanning multiple organ systems. How LTβR-signalling drives chronic tissue damage particularly in the lung, which mechanism(s) regulate this process, and whether LTβR-blockade might be of therapeutic value has remained unclear. Here we demonstrate increased lymphotoxin expression of LTbR-ligands on myeloid and adaptive and innate immune-cells, enhanced non-canonical NF-κB signalling and enrichment of LTβR-target gene expression in epithelial cells of lungs from patients and mice with smoking-associated chronic obstructive pulmonary disease (COPD). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
27 Samples
Download data: TXT
Series
Accession:
GSE125521
ID:
200125521
11.

Transcriptomic analysis of lung tissue from cigarette smoke induced emphysema murine models and human COPD show shared and distinct pathways

(Submitter supplied) Although cigarette smoke (CS) is the primary risk factor for COPD, the underlying molecular mechanisms for the significant variability in developing COPD in response to CS are incompletely understood. We performed lung gene expression profiling of two different wild-type murine strains (C57BL/6J, NZW/LacJ) and two genetic models with mutations in COPD GWAS genes (HHIP, FAM13A) after 6 months of chronic CS exposure and compared the results to human COPD lung tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
109 Samples
Download data: TXT
Series
Accession:
GSE87292
ID:
200087292
12.

Transcriptional Characterization of Human Embryonic Stem Cell-Derived Endothelial Cells

(Submitter supplied) Differentiation of human embryonic stem cells into endothelial cells (hESC-ECs) has the potential to provide an unlimited source of cells for novel transplantation therapies of ischemic diseases by supporting angiogenesis and vasculogenesis. In this study, we developed an extracellular matrix culture system for increasing endothelial differentiation and free from contaminating animal cells. We investigated the transcriptional changes that occur during endothelial differentiation of hESCs using whole genome microarray, and compared to human umbilical vein endothelial cells (HUVECs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
16 Samples
Download data: TXT
Series
Accession:
GSE20013
ID:
200020013
13.

Transcriptome in alveolar epithelial type II-like cells differentiated from human lung progenitor cells

(Submitter supplied) Resident stem/progenitor cells in lungs are important for tissue homeostasis and repair. We isolated human lung progenitor cells and named alveolar epithelial progenitor cells (AEPCs)(Fujino N, et al. 2011. Lab Invest. 91:363). AEPCs have phenotypes of both alveolar epithelial type II (ATII) cells and mesenchymal stem cells. AEPCs had the potential to generate ATII-like cells in vitro. ATII-like cells derived from AEPCs expressed protein and mRNA of pulmonary surfactant, and displayed lamellar bodies containing the surfactants. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL, CHP
Series
Accession:
GSE33825
ID:
200033825
14.

Expression data from lung of mice bearing mutations of FGFR3 and FGFR4

(Submitter supplied) Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their normal lung morphology at birth, suggesting the sequence of events leading to the phenotype initiates after birth in this model. Profiling of 4 week-old lung tissues revealed an induction of genes related to elastic fiber assembly in compound mutants.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE15452
ID:
200015452
15.

Late chick lung development

(Submitter supplied) Type IV collagen is the main component of the basement membrane which gives strength to the blood-gas barrier. In avians the formation of the blood-gas barrier happens rapidly and before hatching. We have performed a microarray expression analysis in late chick lung development and found that COL4A1 and COL4A2 were among the most significantly upregulated genes during the formation of the avian blood-gas barrier. more...
Organism:
Gallus gallus
Type:
Expression profiling by array
Platform:
GPL20851
12 Samples
Download data: PAIR
Series
Accession:
GSE72385
ID:
200072385
16.

Expression data from interstital murine lung fibroblasts

(Submitter supplied) Lung alveoli form a epithelial-mesenchymal trophic unit. We performed microarray analyses on two distinct subsets of PDGFRa expressing interstitial lung fibroblast populations and idenitfied a myo (dim) and matrix (bright) fibroblast signature.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11180
12 Samples
Download data: CEL
Series
Accession:
GSE66943
ID:
200066943
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