GEO DataSets

(Submitter supplied) In the alveoli, lung fibroblasts are in close contact with alveolar epithelial cells type 2, and are considered to support alveolar epithelial cells, forming an alveolar stem cell niche. However, what fibroblast-to-epithelial cell interactions occur during the alveolar maturation stage remains unclear. To understand the lung fibroblast-to-epithelial cell interactions, we performed time-course 3´SAGE-seq analysis of lung epithelial cells and fibroblasts.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18635

21 Samples

Download data: TXT

(Submitter supplied) We investigated whether cell transplantation potential differs between the different developmental stages of the lungs. We found that epithelial cells derived from different developmental stages show different engraftment potential. To identify transcriptional signatures of epithelial cells that are associated with the phenomenon, we performed a time series transcriptome analysis of epithelial cells of the developing lungs.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18635

7 Samples

Download data: TXT

(Submitter supplied) We investigated whether in vitro expansion of human alveolar epithelial type II cells is possible. We found that human endogenous human alveolar epithelial type II cells can be cultured and passaged. The culture system enabled retroviral gene transduction into human alveolar epithelial type II cells. We performed RNA sequencing of human alveolar epithelial type II cells transduced with mutant surfactant protein C or control vector.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23934

6 Samples

Download data: TXT

(Submitter supplied) Lung alveoli form a epithelial-mesenchymal trophic unit. We performed microarray analyses on two distinct subsets of PDGFRa expressing interstitial lung fibroblast populations and idenitfied a myo (dim) and matrix (bright) fibroblast signature.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11180

12 Samples

Download data: CEL