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Links from GEO DataSets

Items: 20

1.

Effect of Notch Signaling Inhibitor on Gene Expression in Lipopolysaccharide-stimulated Macrophages in the Presence of Immune Complex

(Submitter supplied) Lipopolysaccharide (LPS)/immunue complex (IC) stimulated macrophages produce cytokine profiles that differe from LPS-stimulated inflammatory macropahges. Notch signaling is activated in LPS/IC-stimulated macrophages and inhibition of Notch signaling reduced IL-10 production. This study investigated the effect of gamma-secretase inhibitor (GSI) that suppresses Notch signaling pathway, on gene expression profiles in macrophages activated by LPS/IC.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
16 Samples
Download data: TXT
Series
Accession:
GSE114020
ID:
200114020
2.

Epigenetic Regulation in Activated Macrophages

(Submitter supplied) In this study, we compared active histone marks (trimethylation on lysine 4 on histone 3 (H3K4me3)) in LPS-stimulated macrophages and LPS/IC-stimulated macrophages using bone marrow derived murine macrophages using ChIP-seq approach.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23479
12 Samples
Download data: BEDGRAPH, WIG
Series
Accession:
GSE129284
ID:
200129284
3.

caArray_bonda-00136: Molecular basis of age associated cytokine dysregulation in LPS stimulated macrophages

(Submitter supplied) Aged humans and rodents are susceptible to infection with Streptococcus pneumoniae bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines and increased production of interleukin (IL)-10 by macrophages (Mphi) from aged mice. To understand the molecular basis of cytokine dysregulation in aged mouse Mphi, a microarray analysis was performed on RNA from resting and lipopolysaccharide (LPS)-stimulated Mphi from aged and control mice using the Affymetrix Mouse Genome 430 2.0 gene chip. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE68580
ID:
200068580
4.

Effect of interferon-gamma on macrophage differentiation and response to Toll-like receptor ligands

(Submitter supplied) Gene expression analysis of freshly isolated CD14+ human monocytes and monocytes cultured in the presence or absence of interferon (IFN) -gamma for 24 h and then stimulated with Pam3Cys, a Toll-like receptor (TLR) 2 ligand, for 6 h. Results provide insight into mechanisms by which IFN-gamma reprograms early macrophage differentiation and subsequent response to TLR ligands.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE11864
ID:
200011864
5.

The non-canonical Notch ligand DNER regulates IFNγ in macrophages during COPD progression

(Submitter supplied) Chronic Obstructive Pulmonary Diseases (COPD) is the third leading cause of death worldwide with no curative therapy available. A novel non-canonical Notch ligand, DNER, has been identified in a GWAS to correlate with disease severity, but its function and contribution to COPD is completely unknown. DNER localization and expression was determined in COPD patients and 6 month cigarette smoke (CS)-exposed mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16570
18 Samples
Download data: CEL
Series
Accession:
GSE119257
ID:
200119257
6.

Effect on small molecule RBPJ inhibitor (RIN1) on gene expression in Jurkat cells compared to gamma secretase inhibition and siRNA knockdown of RBPJ

(Submitter supplied) We discovered a new class of small molecule inhibitor that disrupts the interaction between NOTCH and RBPJ, which is the main transcriptional effector of NOTCH signaling. RBPJ Inhibitor-1 (RIN1) also blocked the functional interaction of RBPJ with SHARP, a scaffold protein that forms a transcriptional repressor complex with RBPJ in the absence of NOTCH signaling. RIN1 induced changes in gene expression resembled siRNA silencing of RBPJ rather than inhibition at the level of NOTCH itself. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
14 Samples
Download data: TXT
Series
Accession:
GSE134401
ID:
200134401
7.

Murine Colon26 cells: Primary vs. liver metastasis

(Submitter supplied) Transcriptional profiling of mouse Colon26 cancer cells comparing control primary tumours in the colon with their liver metastases. Keywords: Metastatic variant
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL5642
2 Samples
Download data: GPR
Series
Accession:
GSE12162
ID:
200012162
8.

Regulation of miRNAs in macrophages in response to Candida albacans

(Submitter supplied) In this study we have analysed the regulation of miRNA in bone marrow derived macrophages in response to the fungal pathogen heat killed Candida albicans and bacterial cell wall component, LPS. The aim of the study was to identify and validate miRNAs involved in the innate immune system in response to fungal and bacterial stimuli and investigate potential mechanisms for their transcription.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL10458
5 Samples
Download data: XLS
Series
Accession:
GSE21970
ID:
200021970
9.

Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells

(Submitter supplied) Macrophages are innate immune cells that contribute to fighting infections, tissue repair, and maintaining tissue homeostasis. To enable such functional diversity, macrophages resolve potentially conflicting cues in the microenvironment via mechanisms that remain unclear. Here, we use single-cell RNA sequencing to explore how individual macrophages respond when co-stimulated with the inflammatory stimuli, LPS+IFN-γ, and the resolving cytokine, IL-4. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: MTX, TSV
Series
Accession:
GSE161125
ID:
200161125
10.

Pharmacological disruption of the Notch transcription factor complex

(Submitter supplied) Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance and resistance to cancer therapy. Several strategies, such as monoclonal antibodies (MAbs) against Notch ligands and receptors, as well as small molecule -secretase inhibitors (GSIs), have been developed to interfere with Notch receptor activation at proximal points in the pathway. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
18 Samples
Download data: TSV, TXT
Series
Accession:
GSE148228
ID:
200148228
11.

Targeting of the NOTCH transcription complex by a novel small molecule inhibitor CB-103

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
12 Samples
Download data: CEL
Series
Accession:
GSE142408
ID:
200142408
12.

Targeting of the NOTCH transcription complex by a novel small molecule inhibitor CB-103 in KOPT-K1 cells

(Submitter supplied) We used microarrays to study the transcriptional networks controlled by CB-103 in KOPT-K1 human cell line.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
6 Samples
Download data: CEL
Series
Accession:
GSE142407
ID:
200142407
13.

Targeting of the NOTCH transcription complex by a novel small molecule inhibitor CB-103 in HPB-ALL cells

(Submitter supplied) We used microarrays to study the transcriptional networks controlled by CB-103 in HPB-ALL human cell line.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
6 Samples
Download data: CEL
Series
Accession:
GSE142406
ID:
200142406
14.

Gene expressions of TCRαβ+ CD8αα+ intraepithelial lymphocyte (IELs) in the small intestine with or without Rbpj gene

(Submitter supplied) cDNA microarray data of TCRαβ+ CD8αα+ IELs in the small intestine with or without Rbpj gene
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
2 Samples
Download data: TXT
Series
Accession:
GSE117122
ID:
200117122
15.

TRPM5 Negatively Regulates Lipopolysaccharide-Induced Ca2+ Signaling of B Lymphocytes

(Submitter supplied) Ca2+ signaling cascades are essential for various immune cell functions. As such, most cells have negative regulators of Ca2+ homeostasis that strictly regulate cytosolic Ca2+ concentration, such as Ca2+-activated monovalent cation channels (CAMs). Transient receptor potential melastatin-related 5 channel (TRPM5), a CAM, is expressed in B lymphocytes. However, its functional role in the immune system is poorly understood. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE134443
ID:
200134443
16.

Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21103 GPL19057
161 Samples
Download data: TXT
Series
Accession:
GSE128662
ID:
200128662
17.

Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity (ATAC-Seq)

(Submitter supplied) Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood. Here, we characterized transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways and transcription factors that promote Kupffer cell differentiation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
23 Samples
Download data: TXT
Series
Accession:
GSE128659
ID:
200128659
18.

Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity (ChIP-Seq)

(Submitter supplied) Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood. Here, we characterized transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways and transcription factors that promote Kupffer cell differentiation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL19057 GPL21103
34 Samples
Download data: TXT
Series
Accession:
GSE128658
ID:
200128658
19.

Liver-derived signals sequentially reprogram myeloid enhancers to initiate and maintain Kupffer cell identity (RNA-Seq)

(Submitter supplied) Tissue environment plays a powerful role in establishing and maintaining the distinct phenotypes of resident macrophages, but the underlying molecular mechanisms remain poorly understood. Here, we characterized transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways and transcription factors that promote Kupffer cell differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL19057
104 Samples
Download data: TXT
Series
Accession:
GSE128657
ID:
200128657
20.

Gene expression profiling of LPS and menthol treatment on mouse macrophages

(Submitter supplied) To characterize the effect of menthol on macrophages, comprehensive microarray analysis was performed in RAW 264.7 macrophage.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE98933
ID:
200098933
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