Similar studies for GEO DataSets (Select 200117334) - GEO DataSets

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Items: 2

Select item 2001173341.

Z-DNA Binding Protein 1 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells

(Submitter supplied) The aim of this study is to investigate the role of ZBP1 in regulation of osteogenic differentiation of mouse bone marrow derived mesenchymal stem/progenitor cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
4 Samples

Download data: TXT

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Accession:: GSE117334

ID:: 200117334

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000845002.

TGFbeta-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells

(Submitter supplied) Gene Expression analysis of a differentiation timeseries of human Mesenchymal Stem Cells (hMSCs) in the presence of adipogenic/osteogenic factors. hMSCs differentiate into fat cells when treated with dexamethasone (10^-6 M), insulin (10 ug/ml), rosiglitazone (10^-7 M) and IBMX (250 uM). TGFbeta (5 ng/ml) inhibits this process and redirects these cells to differentiate into bone cells. Introduction: Patients suffering from osteoporosis show an increased number of adipocytes in their bone marrow, concomitant with a reduction in the pool of human mesenchymal stem cells (hMSCs) that are able to differentiate into osteoblasts, thus leading to suppressed osteogenesis. more...