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Links from GEO DataSets

Items: 20

1.

Affymetrix Gene Expression array data for Tcl1 mouse model samples

(Submitter supplied) Tcl1 is known to be involved in survival, proliferation and differentiation of human lymphocytes and mouse embryonic stem cells. Loss of Tcl1 gene in the KO mouse model affects skin integrity inducing alopecia and ulcerations. The study used epidermal keratinocytes from wild type (WT), Tcl1 knock down (KO) and K14-driven TCL1 transgenic (TGKO) mouse models to investigate the role of Tcl1 gene in the skin homeostasis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE118345
ID:
200118345
2.

ROR1 Can Interact With TCL1 And Enhance Leukemogenesis in Eµ-TCL1 Transgenic Mice

(Submitter supplied) Transcriptome analysis of RNA samples from leukemia cells of ROR1xTCL1 and TCL1 transgenic mice Animals engrafted with ROR1xTCL1 leukemia-cells developed more aggressive disease than mice engrafted with TCL1 leukemia cells. Transcriptome analysis of RNA samples from leukemia ROR1xTCL1 transgenic mice revealed shared common gene expression signatures that were distinct from those of TCL1 leukemia-cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE51420
ID:
200051420
3.

Gene expression profile of splenic CD19 cells from NTg, PTPROt Tg, TCL1 Tg and PTPROt/TCL1 double Tg mice

(Submitter supplied) TCL1 is an an oncogene and transgenic (Tg) mice expressing TCL1 specifically in B-cells are well-characterized models for chronic lymphocytic leukemia. On the contrary, PTPROt is a phosphatase with tumor suppressor characteristics in many cancers including leukemia. Our hypothesis was that transgenic expression of PTPROt in the B-cells of TCL1 Tg mice will alleviate disease phenotype and allow the study of the in vivo mechanism of action of PTPROt. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE60582
ID:
200060582
4.

Expression data from Transgenic mice skin expressing deltaNp63alpha

(Submitter supplied) We developed a Tet-inducible system to express deltaNp63alpha isoform under the control of keratin 5 promoter. Transgenic mice, which were Bigenic (BG) developed a severe skin phenotype with abnormal keratinocyte differentiation and defects in hair follicle development and cycling. Skin samples from transgenic animals and wild type animals were analyzed for global transcriptome changes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE20514
ID:
200020514
5.

CLL in Em-TCL1 mice provides a biologically relevant model to unravel and reverse immune deficiency in human cancer.

(Submitter supplied) Immune deficiency is common in cancer, but the biological basis for this and ways to reverse it remains elusive. Here we present a mouse model of B cell chronic lymphocytic leukemia (CLL) that recapitulates changes in the non-malignant circulating T cells seen in patients with this illness.1 To validate this model, we examined changes in T cell gene expression, protein expression and function in Em-TCL1 transgenic mice as they developed CLL 2,3 and demonstrate that development of CLL in these transgenic mice is associated with changes in impaired T cell function and in gene expression in CD4 and CD8 T cells similar to those observed in patients with this disease. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
56 Samples
Download data: CEL, TXT
Series
Accession:
GSE8836
ID:
200008836
6.

Accelerated progression of chronic lymphocytic leukemia in Eμ-TCL1 mice expressing catalytically inactive RAG1

(Submitter supplied) B cell chronic lymphocytic leukemia (CLL) is often preceded by a benign monoclonal or oligoclonal CD5+ B cell lymphocytosis. We have generated transgenic mice expressing a catalytically inactive, dominant-negative recombination activating gene 1 (dnRAG1 mice) in the periphery. These animals develop an early-onset indolent CD5+ B cell lymphocytosis, caused in part by a defect in secondary V(D)J rearrangements initiated to alter autoreactive B cell receptor specificity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
18 Samples
Download data: CEL, TXT
Series
Accession:
GSE44940
ID:
200044940
7.

Gene expression profile of keratinocyte stem cells

(Submitter supplied) Background: Human interfollicular epidermis is sustained by the proliferation of stem cells and their progeny, transient amplifying cells. Molecular characterization of these two cell populations is essential for better understanding of self renewal, differentiation and mechanisms of skin pathogenesis. The purpose of this study was to obtain gene expression profiles of alpha 6+/MHCI+, transient amplifying cells and alpha 6+/MHCI- , putative stem cells, and to compare them with existing data bases of gene expression profiles for mouse hair follicle stem cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE11089
ID:
200011089
8.

Knockout of GPx4 gene in mouse keratinocyte

(Submitter supplied) Comparative analysis of gene expression in cultured primary keratinocytes isolated from newborn control (K14-cre; GPx4fl/+) and knockout (K14-cre; GPx4fl/fl) mice. Selenoproteins are essential for skin function, as targeted abolition of selenoproteins in epidermal tissue results in newborn mice manifesting gross abnormalities of skin and hair, accompanied by retarded growth and premature death. To investigate whether lack of a single selenoprotein could induce similar phenotypic effect in mice, we generated keratinocyte-specific knockout mice lacking glutathione peroxidase 4 (GPx4), an essential selenoprotein in skin, to examine phenotypic changes resulting from the lack of GPx4 in skin. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE34215
ID:
200034215
9.

The phosphatase regulator NIPP1 controls epidermal homeostasis

(Submitter supplied) To delineate the in vivo function of NIPP1 in epidermal homeostasis, we generated skin-specific NIPP1 knockout (SKO) mice where NIPP1 is conditionally removed from keratinocytes. To gain unbiased insight into the molecular mechanism that underlies the hyperproliferation phenotype, we performed RNA-seq of the isolated epidermis of control (CTR) and SKO mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: TXT
Series
Accession:
GSE116844
ID:
200116844
10.

Genes differentially regulated by the glucocorticoid receptor in developing skin of the GR knock out and wt embryos.

(Submitter supplied) To understand the transcriptional program by which GR regulates skin development, we performed a microarray analysis using the skin of E18.5 GR-/- and GR+/+ mouse embryos.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE23724
ID:
200023724
11.

Long-term expansion and differentiation of adult murine epidermal stem cells in three-dimensional organoid cultures

(Submitter supplied) Mammalian epidermal stem cells maintain homeostasis of skin epidermis and contribute to its regeneration throughout adult life. While two-dimensional mouse epidermal stem cell cultures have been established decades ago, a long-term, feeder cell- and serum-free culture system recapitulating murine epidermal architecture has not been available. Here we describe an epidermal organoid culture system that allows long-term, genetically stable expansion of adult epidermal stem cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
32 Samples
Download data: CSV
Series
Accession:
GSE104521
ID:
200104521
12.

Expression data from miR-203 induction in mouse skin

(Submitter supplied) We identify numerous miR-203 in vivo targets that are highly enriched for the promotion of cell cycle and cell division. Importantly, individual targets including p63, Skp2 and Msi2 play distinct roles downstream of miR-203 to regulate the cell cycle and long-term proliferation. Together, our findings reveal rapid and widespread impact of miR-203 on the self-renewal program during the epidermal differentiation and provide mechanistic insights for the potent role of miR-203 where coordinated repression of multiple targets is required for the function of this miRNA. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE45121
ID:
200045121
13.

Transcriptional profiling of SmoM2 expressing IFE cells at different stages of basal cell carcinoma formation

(Submitter supplied) Basal cell carcinoma initiating cells undergo profound and rapid reprogramming into embryonic hair follicle progenitor like fate upon SmoM2 expression. Activation of Wnt/β-catenin signaling pathways is required in a cell autonomous manner for the reprogramming of adult IFE progenitors into EHFP-like fate as well as for tumor initiation. We used MA to define the molecular changes that occur in basal cell carcinoma initiating cells form the first oncogenic hit to the development of invasive tumor and further on to investigate the role of Wnt/β-catenin signaling activation in molecular changes occurring early during BCC development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE40612
ID:
200040612
14.

Hair follicle stem cells sense niche integrity and recruit immune cells to contain barrier breaches

(Submitter supplied) We demonstrated that hair follicle stem cells (HFSCs) are able to sense the integrity of their epithelial niche. By ablating a core cell junction component E-cadherin (encoded by Cdh1), the epithelial niche no longer maintains proper barrier function, leading to microbial infiltration through the hair follicle. The surrounding HFSCs respond by increasing its expression of immune associated genes and recruiting immune cells to their niche so as to cope with compromised tissue function.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
22 Samples
Download data: TAB
Series
Accession:
GSE106767
ID:
200106767
15.

Mechanical stretch induces hair regeneration through the alternative activation of macrophages

(Submitter supplied) Tissues and cells in organism are continuously exposed to a complicated set of mechanical cues from the environment. Mechanical stimulations affect cell proliferation, differentiation, migration, and determine tissue homeostasis as well as repair. By using a specially designed skin-stretching device, we discover hair stem cells proliferate in response to stretch and hair regeneration occurs only when proper strain and duration were delivered. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
2 Samples
Download data: TXT
Series
Accession:
GSE125806
ID:
200125806
16.

Transcriptomic characterization of CXCR4C1013G and Eµ-TCL1;CXCR4C1013G CD19+ B cells

(Submitter supplied) Aberrant CXCR4 activity has been implicated in lymphoma pathogenesis, disease progression and resistance to therapies. Using a mouse model with a gain-of-function CXCR4 mutation (CXCR4C1013G) that hyperactivates CXCR4 signaling, we identified CXCR4 as a crucial activator of multiple key oncogenic pathways. CXCR4 hyperactivation furthermore resulted in an expansion of transitional B1 lymphocytes, which represent the precursors of chronic lymphocytic leukemia (CLL). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
40 Samples
Download data: TXT
Series
Accession:
GSE178959
ID:
200178959
17.

Single Cell RNA-sequencing of murine tail interfollicular epidermis basal cells at postnatal days 7, 30 and in adult

(Submitter supplied) The purpose of this study was to define, at the single cell level, the transcriptionnal profile of murine tail epidermal basal cells during potsnatal growth and to compare with adult homeostatic basal cells. The analysis was performed on Lgr5DTR-EGFP mice (Tian et al., 2011)(knockin mice containing an Enhanced Green Fluorescent Protein (EGFP) under the control of the Lgr5 regulatory region), allowing to identify and exclude Lgr5-expressing cells of the bulge and basal cells of the interfollicular epidermis were enriched using EGFP negative, CD34 negative, alpha6 integrin positive gating. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
3 Samples
Download data: CSV, MTX, RDS, TSV
Series
Accession:
GSE146122
ID:
200146122
18.

Defining the design principles of postnatal tissue growth

(Submitter supplied) SMARTseq2 scRNAseq of interfollicular epidermis basal cells at P20
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
188 Samples
Download data: CSV
Series
Accession:
GSE122817
ID:
200122817
19.

Role of TCHHL1 (trichohyalin-like 1) on the proliferation of normal human epidermal keratinocytes

(Submitter supplied) TCHHL1 (trichohyalin-like 1) protein is a novel member of the fused-type S100 protein gene family. Previous findings suggest that TCHHL1 may play a role in the proliferation of keratinocytes. In the present study, to clarify a role of TCHHL1 in the proliferation of keratinocytes, we performed global-scale gene expression analysis in TCHHL1-Knockdown keratinocytes using an Affymetrix GeneChip® system.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE136127
ID:
200136127
20.

Expression data from keratinocytes of WT and RASSF9-/- mice

(Submitter supplied) Mice with deficient expression of RASSF9 exhibit intriguing phenotypes of skin-related pathology, including abnormal thickening of the epidermis, dysregulated proliferation of keratinocytes, and alopecia. To delineate the underlying mechanism, we profiled gene expression in keratinocytes of RASSF9-mutant mice to identify targets whose expressions were affected by RASSF9 gene deletion.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE24190
ID:
200024190
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