Similar studies for GEO DataSets (Select 200120161) - GEO DataSets

Select item 2001201611.

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

(Submitter supplied) How neuronal connections are established and organized in functional networks determines brain function. In the mouse cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made parsing interneuron diversity, yet the molecular mechanisms by which interneuron subtype-specific connectivity motifs emerge remain unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
29 Samples

Download data: DIFF, XLSX

Series

Accession:: GSE120161

ID:: 200120161

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001199982.

Rbfox1 mediates cell-type specific splicing in cortical interneurons

(Submitter supplied) Cortical interneurons display a remarkable diversity in their morphology, physiological properties and connectivity. Elucidating the molecular determinants underlying this heterogeneity is essential for understanding interneuron development and function. We discovered that alternative splicing differentially regulates the integration of somatostatin- and parvalbumin-expressing interneurons into nascent cortical circuits through the cell-type specific tailoring of mRNAs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
23 Samples

Download data: BW

Series

Accession:: GSE119998

ID:: 200119998

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000908603.

Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing

(Submitter supplied) Cortical GABAergic interneurons constitute a highly diverse population of inhibitory neurons that are key regulators of cortical microcircuit function. An important and heterogeneous group of cortical interneurons specifically expresses the serotonin receptor 3A (5-HT3AR) but how this diversity emerges during development is poorly understood. Here we use single-cell transcriptomics to identify gene expression patterns operating in Htr3a-GFP+ interneurons during early steps of cortical circuit assembly. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
223 Samples

Download data: TSV

Series

Accession:: GSE90860

ID:: 200090860

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001159484.

Identification of genes involved in GABAergic Wiring

(Submitter supplied) How neurons are wired to form precise circuits is crucial to understand the development of cortical functions. Glutamatergic pyramidal cell and GABAergic interneuron wire up the cortex through differentiated cellular events. However, little is known about the molecular mechanisms that underlie the unique features of interneuron wiring. We performed a high-throughput genomic screen for genes upregulated specifically during GABAergic wiring.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE115948

ID:: 200115948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001538245.

Complementary networks of cortical somatostatin interneurons enforce layer specific control

(Submitter supplied) The neocortex is functionally organized into layers. Layer four receives the densest bottom up sensory inputs, while layers 2/3 and 5 receive top down inputs that may convey predictive information. A subset of cortical somatostatin (SST) neurons, the Martinotti cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in layers 2/3 and 5, but it is unknown whether an analogous inhibitory mechanism controls activity in layer 4. more...