GEO DataSets

(Submitter supplied) Background: In immunodeficient mice, the growth and egg laying of schistosome were significantly retarded or inhibited, and their virulence on the host was also weakened. Some studies have suggested that host factors including endocrine and immune signals can modulate the parasite’s development and maturation. However, it is still not clear for the molecular mechanisms underlying the growth and maturation regulation of schistosome. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25265

4 Samples

Download data: FASTA, GTF, XLS

(Submitter supplied) Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

24 Samples

Download data: PAIR

(Submitter supplied) In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL18617

23 Samples

Download data: PAIR

(Submitter supplied) We have used a Schistosoma japonicum infected murine model with in vivo sub-lethal dosages of praziquantel against adult parasites. Differential gene expression of parasites was followed between 30 minutes and 24 hours post- drug administration, using a whole transcriptome microarray platform. Differential gene expression was considered separately between parasite gender.

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL9759

20 Samples

Download data: TXT

(Submitter supplied) Macrophages possess the hallmark feature of plasticity, allowing them to undergo a dynamic transition between M1 and M2 polarized phenotypes. The aim of the present study was to screen for differentially expressed genes (DEGs) that were associated with macrophage polarization. The transcription profiles of three M1 and three M2 samples were obtained using microarray analysis. Based on the threshold of fold-change >2.0 and a p-value < 0.05, we screened a total of 1,253 DEGs, of which 696 were upregulated and 557 downregulated in M1 macrophages compared to that in M2 macrophages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20939

6 Samples

Download data: TXT

(Submitter supplied) We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production.

Organism:

Schistosoma japonicum

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL20772

8 Samples

Download data: TXT

(Submitter supplied) In this study, we isolated and identified the small RNAs associated with the S. japonicum Argonaute protein, SjAgo1, by HITS-CLIP combined with bioinformatic analysis. These data reveal a genome-wide miRNA-mRNA interaction map in S. japonicum in vivo, which will help us understand the complex gene regulation network in this pathogen and thereby facilitate to develop novel approaches against Schistosomiasis.

Organism:

Schistosoma japonicum

Type:

Other

Platform:

GPL11650

1 Sample

Download data: FA, TXT

(Submitter supplied) Purpose: To obtain the differentially expressed genes based on post-RNAi transcriptional profiling analysis of females and males, which provide a more comprehensive overview about the effects of Sj-pp1c knockdown on schistosoma developmental and reproduction biology at the molecular level. Methods: Schistosoma japonicum females and males were collected from 21 days post infection worm pairs that untreated (Blank,BLA_FE/M) or treated with combined Sj-pp1c dsRNAs (Sj-pp1c KD,PP1_FE/M) cultured for 7 d in vitro. more...

Organism:

Schistosoma japonicum

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20772

12 Samples

Download data: TXT

(Submitter supplied) The microarray analysis of gene expression difference between cattle,buffalo and goat,provide us a profiling as a new platform to discover the difference between their compatibility

Organism:

Schistosoma japonicum

Type:

Expression profiling by array

Platform:

GPL10987

9 Samples

Download data: TXT

(Submitter supplied) βAlanyl-tryptamine (BATT) is a peptide secreted by male S. mansoni upon pairing with a female parasite. Treatment of synthetic BATT on virgin females wihtout any pairing is sufficient to induce sexual development and egg depostiion.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

6 Samples

Download data: CSV

(Submitter supplied) gli1 is a gene in the male S. mansoni required for female sexual development. As a putative transcription factor, RNAseq comparing pairs with gli1 knocked-down or control males was performed to look for the genes which are trancriptionally regulated by gli1. sm-nrps was one of the essential candidate discovered in this analysis that has been characterized in the same publication, revealing a pheromone directed novel mechanism of female schistosome sexual development.

Organism:

Schistosoma mansoni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28252

24 Samples

Download data: CSV