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Links from GEO DataSets

Items: 15

1.

Collateral DNA damage and NAD+ dependence caused by reactive oxygen species signaling in inflammatory macrophages

(Submitter supplied) Adoption of Warburg metabolism is critical for macrophage activation in response to lipopolysaccharide (LPS). Macrophages stimulated with LPS (without or with interferon-γ) increase expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in NAD+ salvage, and loss of NAMPT activity alters their inflammatory potential. However, events leading to NAD+ salvage-dependence in these cells remain poorly defined. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
24 Samples
Download data: TXT
Series
Accession:
GSE123596
ID:
200123596
2.

Triacylglycerol synthesis enhances macrophage inflammatory function

(Submitter supplied) Macrophages stimulated with lipopolysaccharide (LPS) plus interferon-g (IFNg) accumulate TGs in LDs, and long-chain acylcarnitines. Inhibition of TG synthesis results in diminished LD development, and increased long chain acylcarnitine levels, suggesting that FA fate is balanced between TG and acylcarnitine synthesis. Nevertheless, TG-synthesis is required for inflammatory macrophage function, since its inhibition negatively affects production of proinflammatory IL-1b, IL-6 and PGE2, and phagocytic capacity, and protects against LPS-induced sock in vivo.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
12 Samples
Download data: TXT
Series
Accession:
GSE145523
ID:
200145523
3.

Expression data of peritoneal macrophages from Wild-type mouse cultured in control or serine/glycine-depleted medium.

(Submitter supplied) Activation of signaling pathways downstream of Toll-like receptor 4 upregulate expression of genes related to serine metabolism. We cultured peritoneal macrophages in control or serine/glycine-depleted medium for 24 hr, stimulated them with LPS (10 ng/ml) for 6 or 12 hr, and collected them to compare the gene expression. Microarray analysis revealed that serine/glycine-depletion in peritoneal macrophages upregulates gene expression of enzymes for serine biosynthesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE156325
ID:
200156325
4.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and cd36-/- murine peritoneal macrophage Transcriptomes

(Submitter supplied) Oxidized LDL induce macrophages to turn into foam cells in a CD36 dependent manner. The Goal of this study is to compare transcriptome profile by RNA-seq among WT/CD36 knockout macrophages treated with or without oxLDL. We detected re-organization of lipid metabolisms as well as immune activation by oxLDL.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: XLSX
Series
Accession:
GSE139439
ID:
200139439
5.

TLR4 deficiency reduces inflammatory signaling by reprogramming macrophage lipid metabolism

(Submitter supplied) Chronic inflammation is a hallmark of obesity and is linked to the development of numerous diseases. The activation of toll-like receptor 4 (TLR4) by long-chain saturated fatty acids (lcSFAs) is an important process in understanding how obesity initiates inflammation. While experimental evidence supports an important role for TLR4 in obesity-induced inflammation in vivo, via a mechanism thought to involve direct binding to and activation of TLR4 by lcSFAs, several lines of evidence argue against lcSFAs being direct TLR4 agonists. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: TXT
Series
Accession:
GSE100526
ID:
200100526
6.

Oxidative metabolism and PGC-1 attenuate macrophage-mediated inflammation

(Submitter supplied) Total RNA was prepared from three independent experimental replicates using Trizol reagent (Invitrogen) and validated by northern blot. Microarray experiments were performed with 20-25 ?g of total RNA, which was labelled with fluorescent nucleotides and hybridized to murine cDNA slides. Hybridized slides were interrogated via an Agilent scanner. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL3843
9 Samples
Download data
Series
Accession:
GSE5003
ID:
200005003
7.

Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

(Submitter supplied) Purpose: The goal of this study is to compare downstream genes of Sema6D signaling in LPS plus IFNg stimulated macrophages. Methods: Bone marrow derived macrophage mRNA profiles of 7 weeks of wild type (WT) and Sema6D-/- mice were stimulated by LPS for 4 hrs. Results: According to this comparison, we found that 550 genes were downregulated in Sema6D-/- macrophages than WT macrophages in response to LPS. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
4 Samples
Download data: TXT
Series
Accession:
GSE99047
ID:
200099047
8.

Sema6D reverse signaling controls lipid metabolism for macrophage polarization linking mTOR to PPARγ

(Submitter supplied) The goal of this study is to compare downstream genes of Sema6D signaling in both M1 and M2 macrophages.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE99046
ID:
200099046
9.

Transcriptome analysis reveals non-foamy rather than foamy plaque macrophages are pro-inflammatory in atherosclerotic murine models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL21493
8 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE116271
ID:
200116271
10.

Single cell RNA sequencing of aortic CD45+ cells and foam cells from atherosclerotic aorta

(Submitter supplied) In atherosclerosis, several immune cells are involved in plaque formation. Foam cell formation is a major cellular process in atherosclerotic lesion. It is important to understand which cells participate in foam cell formation. To characterize the immune cells and foam cells in atherosclerotic aorta, we performed single cell RNA sequencing of aortic CD45+ leukocytes from Ldlr-/- mice and foamy cells from ApoE-/- mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE116240
ID:
200116240
11.

Bulk RNA-seq of foamy and non-foamy intimal macrophages from ApoE -/- mouse

(Submitter supplied) Macrophages in atherosclerotic aorta are major population in lesion and contributes to lesion formation by becoming foam cells. To investigate in vivo transcriptome profiles of those macrophages, we extracted foamy and non-foamy macrophages from atherosclerotic aorta using lipid probe-based flow cytometry sorting. Our data indicates that intima non-foamy and foamy macrophages show different mRNA expressions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
6 Samples
Download data: TXT
Series
Accession:
GSE116239
ID:
200116239
12.

Gene expression profile of peroxisome proliferator-activated receptor delta (Ppard)-overexpressing RAW 264.7 macrophages treated vehicle, GW501516 or interleukin-4 (Il-4)

(Submitter supplied) Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle. Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10192
9 Samples
Download data: PAIR
Series
Accession:
GSE100237
ID:
200100237
13.

Investigation of the effect of succinate and dimethyl malonate on murine bone-marrow derived macrophages (BMDMs) treated with or without LPS

(Submitter supplied) We aim to further elucidate the effect of succinate and the succinate dehydrogenase inhibtor, dimethyl malonate, on macrophages treated with LPS. Specifically we want to deepen our understanding of how these reagents influence both LPS-induced IL-1B and IL-10.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16417
21 Samples
Download data: TXT
Series
Accession:
GSE78849
ID:
200078849
14.

Expression data from human monocyte-derived dendritic cells treated or not with interleukin 17A (IL-17A)

(Submitter supplied) IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodeling of lipid metabolism in human monocyte-derived DC, as revealed by microarrays analysis. In particular NR1H3/LXR-a and its target genes were significantly upregulated in response to IL-17A. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5817
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE53163
ID:
200053163
15.
Full record GDS5817

Interleukin 17A effect on monocyte-derived dendritic cells

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol, 2 time sets
Platform:
GPL570
Series:
GSE53163
9 Samples
Download data: CEL
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