Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.

RNA-sequencing across three matched tissues highlights gene expression signatures in COPD

(Submitter supplied) Multiple gene expression studies have been performed separately in peripheral blood, lung, and airway tissues to study COPD. We performed RNA-sequencing gene expression profiling of large-airway epithelium, alveolar macrophage and peripheral blood samples from the same set of COPD cases and controls from the COPDGene study who underwent bronchoscopy at a single center. Using statistical and gene set enrichment approaches, we sought to improve the understanding of COPD by studying gene sets and pathways across these tissues, beyond the individual genomic determinants.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
63 Samples
Download data: TSV
Series
Accession:
GSE124180
ID:
200124180
2.

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
21 Samples
Download data: BEDGRAPH
Series
Accession:
GSE124725
ID:
200124725
3.

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq]

(Submitter supplied) Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: CSV, TXT
Series
Accession:
GSE124724
ID:
200124724
4.

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq LPS]

(Submitter supplied) Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
6 Samples
Download data: CSV, TXT
Series
Accession:
GSE124723
ID:
200124723
5.

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [ChIP-Seq]

(Submitter supplied) Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: BEDGRAPH
Series
Accession:
GSE124722
ID:
200124722
6.

Induced Sputum Genes Associated With Spirometroc and Radiological Disease Severity in COPD Ex-smokers

(Submitter supplied) Induced sputum is used to sample inflammatory cells, predominantly neutrophils and macrophages, from the airways of COPD patients. Our aim was to identify candidate genes associated with the degree of airflow obstruction and the extent of emphysema by expression profiling, and then to confirm these findings for selected candidates using specific PCR and protein analysis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4265
Platform:
GPL570
143 Samples
Download data: CEL
Series
Accession:
GSE22148
ID:
200022148
7.
Full record GDS4265

Chronic obstructive pulmonary disease in ex-smokers: sputum

Analysis of sputum from ex-smokers with moderate (stage 2) or severe (stages 3, 4) chronic obstructive pulmonary disease (COPD). Induced sputum contains inflammatory cells, predominantly neutrophils and macrophages. Results provide insight into molecular mechanisms underlying COPD progression.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL570
Series:
GSE22148
143 Samples
Download data: CEL
DataSet
Accession:
GDS4265
ID:
4265
8.

Functional interactors of genomewide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue

(Submitter supplied) Multiple gene expression studies have been performed in lung or airway tissues from subjects with chronic obstructive pulmonary disease (COPD). However, in comparison to genome-wide association studies (GWAS), there has been poor replication across these studies. We sought to perform gene expression profiling on a large sample of severe COPD cases and control smokers and use network methods to identify interacting genes and pathways. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
151 Samples
Download data: TXT
Series
Accession:
GSE76925
ID:
200076925
9.

Smoking Dysregulates the Human Airway Basal Cell Transcriptome at COPD-linked Risk Locus 19q13.2

(Submitter supplied) Rationale: Genome-wide association studies (GWAS) and candidate gene studies have identified a number of loci linked to susceptibility of chronic obstructive pulmonary disease (COPD), a smoking-related disorder that originates in the airway epithelium. Objectives: Since airway basal cell (BC) stem/progenitor cells exhibit the earliest abnormalities associated with smoking (hyperplasia, squamous metaplasia), we hypothesized that smoker BC have a dysregulated transcriptome linked, in part, to known GWAS/candidate gene loci. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
17 Samples
Download data: FPKM_TRACKING
Series
Accession:
GSE47718
ID:
200047718
10.

Genes Associated with MUC5AC Expression in the Human Airway Epithelium

(Submitter supplied) To help define the genes associated with mucus synthesis and secretion in the human small airway epithelium, we hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, a major secretory mucin and the major component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production / secretion. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
132 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE34450
ID:
200034450
11.

Whole-genome gene expression profiles of non-tumorous human lung tissues

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
1349 Samples
Download data: CEL
Series
Accession:
GSE23546
ID:
200023546
12.

Whole-genome gene expression profiles of non-tumorous human lung tissues: GRNG set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
445 Samples
Download data: CEL
Series
Accession:
GSE23545
ID:
200023545
13.

Whole-genome gene expression profiles of non-tumorous human lung tissues: UBC set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
405 Samples
Download data: CEL
Series
Accession:
GSE23529
ID:
200023529
14.

Whole-genome gene expression profiles of non-tumorous human lung tissues: Laval set

(Submitter supplied) We profiled genome-wide gene expression in non-tumorous human lung tissues. The overall goal of this project is to improve our molecular understanding of various lung diseases including lung cancer and chronic obstructive pulmonary disease (COPD).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10379
499 Samples
Download data: CEL
Series
Accession:
GSE23352
ID:
200023352
15.

mRNA expression data from either wild-type mice or Scnn1b-transgenic mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6246 GPL11533
84 Samples
Download data: CEL
Series
Accession:
GSE47551
ID:
200047551
16.

mRNA expression data from whole trachea dissected from either wild-type mice or Scnn1b-Tg mice at post-natal days 0, 3, 10, and 42

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47550
ID:
200047550
17.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; and Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84. Briefly, overexpression of the Scnn1b transgene in airway Club cells leads to hyperabsorption of sodium from the airway surface liquid, dehydrated airway surface liquid and mucus, and reduced mucus clearance associated with accumulation of mucus plugs/plaques. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11533
36 Samples
Download data: CEL
Series
Accession:
GSE47548
ID:
200047548
18.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration [left lobe only]

(Submitter supplied) Scnn1b-Tg mice overexpress the beta subunit of the epithelial sodium channel (Scnn1b) in airway Club cells. The general phenotype of these mice is described in three published manuscripts (Mall et al. 2004, Nature Medicine, 10(5):487-93; Mall et al. 2008, Am J Respir Crit Care Med. 177(7):730-42; Livraghi-Butrico et al. 2012, Physiol. Genomics 44(8):470-84; and Livraghi-Butrico et al. 2012, Mucosal Immunology 5(4):397-408). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE47546
ID:
200047546
19.

Variability in Small Airway Epithelial Gene Expression Among Normal Smokers

(Submitter supplied) Despite overwhelming data that cigarette smoking causes chronic obstructive pulmonary disease (COPD), only a minority of chronic smokers are affected, strongly suggesting that genetic factors modify susceptibility to this disease. We hypothesized that there are individual variations in the response to cigarette smoking, with variability among smokers in expression levels of protective / susceptibility genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
54 Samples
Download data: CEL, CHP
Series
Accession:
GSE8545
ID:
200008545
20.

Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking COPD and Lung Cancer

(Submitter supplied) Cystatin A (gene: CSTA), is up-regulated in non-small-cell lung cancer (NSCLC) and dysplastic vs normal human bronchial epithelium. In the context that chronic obstructive pulmonary disease (COPD), a small airway epithelium (SAE) disorder, is independently associated with NSCLC (especially squamous cell carcinoma, SCC), but only occurs in a subset of smokers, we hypothesized that genetic variation, smoking and COPD modulate CSTA gene expression levels in SAE, with further up-regulation in SCC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; SNP genotyping by SNP array
Platforms:
GPL570 GPL6804
342 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE22047
ID:
200022047
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_610aa67ac3d10c5e5e622730|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center