Similar studies for GEO DataSets (Select 200125336) - GEO DataSets

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Items: 20

Select item 2001253361.

β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma

(Submitter supplied) We study the role of CTNNB1 in immune escape in HCC.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
22 Samples

Download data: TXT

Series

Accession:: GSE125336

ID:: 200125336

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001113892.

Gene expression profiles of PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of FACS-sorted PD1-high, PD1-intermediate, and PD1-negative tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: TSV

Series

Accession:: GSE111389

ID:: 200111389

Select item 2001073743.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18802
16 Samples

Download data: CEL

Series

Accession:: GSE107374

ID:: 200107374

Select item 2001532034.

Expression data from syngeneic Hepa1-6 model in C57Bl/6J mice

(Submitter supplied) Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has achieved encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed at exploring the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1. We generated a syngeneic model of HCC in C57BL/6J mice and randomized the animals to receive placebo, lenvatinib, anti-PD1 or combination treatment. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
21 Samples

Download data: CEL

Series

Accession:: GSE153203

ID:: 200153203

Select item 2001483795.

Cooperation between distinct cancer drivers dictates inter-tumor heterogeneity in hepatocellular carcinoma

(Submitter supplied) We generate multiple models of liver cancer to study heterogeneity at different levels

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
60 Samples

Download data: TXT

Series

Accession:: GSE148379

ID:: 200148379

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Select item 2001563866.

Concomitant Nrf2 and beta-catenin activation in hepatocellular cancer subset

(Submitter supplied) In the current study, we want to explore the crosstalk between NFE2L2 and beta-catenin.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
9 Samples

Download data: CSV, WIG

Series

Accession:: GSE156386

ID:: 200156386

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Select item 2000773227.

Niclosamide ethanolamine reverses gene expression and inhibits growth of hepatocellular carcinoma in vitro and in vivo

(Submitter supplied) Hepatocellular carcinoma (HCC) is a fatal malignancy with a dismal prognosis. The recent advances in genomics and transcriptomics have led to large volumes of molecular data for HCC, providing an unprecedented opportunity to translate these data into more effective therapeutics. By creating HCC gene expression signatures and comparing with drug response signatures from multiple datasets, we identified four antihelminthics (from over 1000 FDA-approved drugs) that can reverse the HCC disease gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
9 Samples

Download data: TXT

Series

Accession:: GSE77322

ID:: 200077322

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000936478.

Expression data from patients with HCC receiving Nivolumab

(Submitter supplied) We have generated an immune classifier able to identify patients belonging to the immune subclass of HCC. Characteristics of the immune subclass resemble those of patients who most respond to immunotherapy. We performed microarray expression of the tumors of two patients before starting treatment with nivolumab to verify if the immune classifier generated was able to predict response to immunotherapy.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
2 Samples

Download data: CEL

Series

Accession:: GSE93647

ID:: 200093647

Select item 2000681249.

Zebrafish liver: Tg(fabp10a:pt-beta-catenin) versus non-transgenic control siblings

(Submitter supplied) To investigate mechanisms by which activated β-catenin signaling promotes liver tumor formation and to identify potential therapeutics for these cancers, we generated transgenic zebrafish expressing hepatocyte-specific activated β-catenin (Tg(fabp10a:pt-β-cat) zebrafish. As adults, these animals show increased liver size, decreased survival, and histologic abnormalities similar to human HCC. To further characterize our model, we used microarray analysis to compare gene expression in Tg(fabp10a:pt-β-cat) zebrafish livers to that of non-transgenic control sibling livers.

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL14688
2 Samples

Download data: TXT

Series

Accession:: GSE68124

ID:: 200068124

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013281210.

Gene expression profiles of tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of MACS-sorted tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
10 Samples

Download data: TXT

Series

Accession:: GSE132812

ID:: 200132812

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013281011.

Gene expression profiles of 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma

(Submitter supplied) We report the gene expression profiles of FACS-sorted 4-1BB+PD-1-high, 4-1BB-PD-1-high, and PD-1-int tumor-infiltrating CD8 T cells in hepatocellular carcinoma.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
15 Samples

Download data: TXT

Series

Accession:: GSE132810

ID:: 200132810

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20023977712.

MeDIP-seq profiles of mouse ApcDHep hepatocytes at day 6 vs wt hepatocytes

(Submitter supplied) We analyzed the level of DNA methylation by MeDIPseq in hepatocytes isolated by collagenase perfusion from Apclox/loxlivers, six days after injection of 2mg tamoxifen vs wt hepatocytes. Our aims was to study the impact of the beta-catenin on DNA methylation during the early steps of liver tumorigenesis

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: BW

Series

Accession:: GSE239777

ID:: 200239777

PubMed Similar studies

Select item 20015966013.

Intermittent PI3Kα/β/δ Inhibitor Treatment Alleviates Immunosuppressive Environment in PTEN-null prostate Cancer and facilitate Anti-PD-1 Therapy

(Submitter supplied) Examination of gene expression level in tumor tissue or CD8T cell in vehicle, BAY1082439 (Single dose), BAY1082439 daily/intermittent treatment, BAY1082439 treatment release drug treatment group. Examination of gene expression level in CAP2 CAP8 PC3 and LNCaP cell line in vehicle or BAY1082439 treatment. Examination of gene expression level in spleen CD8T cell in vehicle or intermittent BAY1082439 treatment.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20795 GPL21273
140 Samples

Download data: TXT, XLSX

Series

Accession:: GSE159660

ID:: 200159660

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016444414.

A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
37 Samples

Download data: BW

Series

Accession:: GSE164444

ID:: 200164444

PubMed Similar studies

Select item 20016444315.

A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma [ChIP-seq]

(Submitter supplied) Insufficient T cell infiltration into non-inflamed tumors, such as hepatocellular carcinoma (HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of patients. Epigenetic therapy provides further opportunities to rewire cancer-associated transcriptional programs, but whether and how selective epigenetic inhibition counteracts the immune-excluded phenotype remain incompletely defined. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
20 Samples

Download data: BW

Series

Accession:: GSE164443

ID:: 200164443

PubMed Similar studies

Select item 20016444116.

A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma [RNA-seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
20 Samples

Download data: TXT

Series

Accession:: GSE164441

ID:: 200164441

PubMed Similar studies

Select item 20010040217.

Mouse natural killer cells response to DKK2 treatment

(Submitter supplied) Analysis of mouse primary natural killer (NK) cells and NK cells treated with DKK2 for 24 hours.Sequencing of the mRNAs from DKK2-treated primary NK cells in comparison of those from mock-treated cells suggest an alteration in STAT signaling.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE100402

ID:: 200100402

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016920318.

ZEB1 transcription factor promotes immune escape in melanoma

(Submitter supplied) The efficacy of immunotherapies in metastatic melanoma depends on a robust T cell infiltration. Consistently, defining cancer cell intrinsic mechanisms mediating T cell exclusion and immune resistance is crucial. The EMT inducing transcription factor ZEB1 is a major regulator of melanoma cell plasticity, driving resistance to MAPK targeted therapies. Here, by analyzing the immune infiltrates of a cohort of melanoma patients, we demonstrate that high ZEB1 expression in tumor cells is associated with a decrease in CD8+ T lymphocyte infiltration, independently of beta-catenin pathway activation. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL24676
57 Samples

Download data: TSV

Series

Accession:: GSE169203

ID:: 200169203

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20019096719.

Multi-omics identifies the link between intratumor steatosis and exhausted tumor immune microenvironment in hepatocellular carcinoma

(Submitter supplied) Immunotherapy becomes standard-of-care treatment of hepatocellular carcinoma (HCC) but still limited number of patients benefit from immunotherapy due to the high heterogeneity of tumor immune-microenvironment (TIME) of HCC patients. Therefore, it is important to stratify patients who benefit from immunotherapy by analyzing the molecular and immunological diversity of HCC. Since non-viral HCC is rapidly increasing all over the world, in this study, we focused on non-viral HCC and aimed to identify immunotherapy-susceptible patients through multi-omics. more...