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Links from GEO DataSets

Items: 5

1.

Modular transcriptional programs separately define axon and dendrite connectivity

(Submitter supplied) Patterns of synaptic connectivity are remarkably precise and complex. Single-cell RNA sequencing has revealed a vast transcriptional diversity of neurons. Nevertheless, a clear logic underlying the transcriptional control of neuronal connectivity has yet to emerge. Here, we focused on Drosophila T4/T5 neurons, a class of closely related neuronal subtypes with different wiring patterns. Eight subtypes of T4/T5 neurons are defined by combinations of two patterns of dendritic inputs and four patterns of axonal outputs. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21306
2 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE126139
ID:
200126139
2.

A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons in Drosophila

(Submitter supplied) Direction-selective T4/T5 neurons exist in four subtypes, each tuned to visual motion along one of the four cardinal directions. Along with their directional tuning, neurons of each T4/T5 subtype orient their dendrites and project their axons in a subtype-specific manner. Directional tuning, thus, appears strictly linked to morphology in T4/T5 neurons. How the four T4/T5 subtypes acquire their distinct morphologies development remains largely unknown. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
10 Samples
Download data: MTX, TSV
Series
Accession:
GSE147987
ID:
200147987
3.

Transcriptional programs of circuit assembly in the Drosophila visual system

(Submitter supplied) Precise patterns of synaptic connections between neurons are encoded in their genetic programs. Here we used single-cell RNA sequencing to profile neuronal transcriptomes at multiple stages in the developing Drosophila visual system. We devised an efficient strategy for profiling neurons at multiple time points in a single pool, thereby minimizing batch effects and maximizing the reliability of time-course data. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
36 Samples
Download data: MTX, TSV, TXT
Series
Accession:
GSE156455
ID:
200156455
4.

Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-cell RNA Sequencing

(Submitter supplied) How a neuronal cell type is defined and how this relates to its transcriptome are still open questions. The Drosophila olfactory projection neurons (PNs) are among the bestcharacterized neuronal types: Different PN classes target dendrites to distinct olfactory glomeruli and PNs of the same class exhibit indistinguishable anatomical and physiological properties. Using single-cell RNA-sequencing, we comprehensively characterized the transcriptomes of 40 PN classes and unequivocally identified transcriptomes for 6 classes. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22106
1842 Samples
Download data: CSV, TAB
Series
Accession:
GSE100058
ID:
200100058
5.

Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

(Submitter supplied) How neuronal connections are established and organized in functional networks determines brain function. In the mouse cerebral cortex, different classes of GABAergic interneurons exhibit specific connectivity patterns that underlie their ability to shape temporal dynamics and information processing. Much progress has been made parsing interneuron diversity, yet the molecular mechanisms by which interneuron subtype-specific connectivity motifs emerge remain unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
29 Samples
Download data: DIFF, XLSX
Series
Accession:
GSE120161
ID:
200120161
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