Similar studies for GEO DataSets (Select 200130719) - GEO DataSets

Select item 2001307191.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

(Submitter supplied) We investigated the transcriptional consequences of Chd7 and Runx1 loss in 416B cells, a myeloid progenitor cell line. We engineered the cell line to express Cas9 protein and targeted endogenous Chd7 and Runx1 loci with sgRNAs introduced with lentiviral constructs. We read out the transcriptomes of control and perturbed cells using RNA-Seq following an established SMART-Seq2 protocol (Picelli et al. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
20 Samples

Download data: XLSX

Series

Accession:: GSE130719

ID:: 200130719

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001302802.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation [ATAC-seq]

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: NARROWPEAK

Series

Accession:: GSE130280

ID:: 200130280

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000841363.

Expression Profile of CHD7-Deficient Murine Long-term Hematopoietic Stem Cells

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE84136

ID:: 200084136

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000841314.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL16570 GPL17021
33 Samples

Download data: BED, CEL, NARROWPEAK

Series

Accession:: GSE84131

ID:: 200084131

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000841305.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation [CD34 ChIP-seq]

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
3 Samples

Download data: BED

Series

Accession:: GSE84130

ID:: 200084130

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000841296.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation [G1ER ChIP-seq]

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: NARROWPEAK

Series

Accession:: GSE84129

ID:: 200084129

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000841287.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation [RNA-seq]

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: XLSX

Series

Accession:: GSE84128

ID:: 200084128

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000841278.

Expression analysis of Chd7 in mouse hematopoietic stem and progenitor cells [microarray]

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE84127

ID:: 200084127

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000839569.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

(Submitter supplied) Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Knockdown of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation in a cell autonomous manner in the embryo and adult. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
17 Samples

Download data: BED, BW

Series

Accession:: GSE83956

ID:: 200083956

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016968910.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development [zebrafish bulk RNA-seq2]

(Submitter supplied) Here we used RNAsequencing to characterize the transcriptional profile of the kidney of runx1 knock out zebrafish adult compared to wild type.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
5 Samples

Download data: TXT

Series

Accession:: GSE169689

ID:: 200169689

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015810111.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Danio rerio

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL25922 GPL18413
26 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE158101

ID:: 200158101

PubMed Full text in PMC Similar studies

Select item 20015810012.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) Here we used RNA sequencing to characterize the transcriptional profile of the total RNA from c-Kit+ cells of Runx1 KO and control mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE158100

ID:: 200158100

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015809913.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) We used single cell-RNA sequencing to investigate the expression and the heterogeneity of wild type and runx1-mutant cd41-GFPLow cd41GFP hematopoietic stem and progenitor cells at embryonic (2.5 days post fertilization, dpf) and larval stages (6, 10 16 dpf).

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25922
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE158099

ID:: 200158099

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015809814.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) Here we used RNA sequencing to characterize the transcriptional profile of the kidney of runx1 knock out zebrafish adult compared to wild type.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
6 Samples

Download data: TXT

Series

Accession:: GSE158098

ID:: 200158098

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006259615.

RUNX1 transcription factor genome-wide occupancy in EML cells

(Submitter supplied) We report the application of sequencing technology for high-throughput profiling of RUNX1 transcription factor occupancy in mouse EML cells. RUNX1 antibody was use for chromatin immunoprecipitation followed by high-throughput sequencing to reveal RUNX1 genome occupancy in hematopoietic stem/progenitor cells.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9250
4 Samples

Download data: BED

Series

Accession:: GSE62596

ID:: 200062596

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006895816.

RUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis

(Submitter supplied) The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, crucial for hematopoietic stem cell (HSC) emergence during ontogeny, which also plays vital roles in adult mice, in regulating the correct specification of numerous blood lineages. Akin to the other mammalian Runx genes, Runx1 has two promoters P1 (distal) and P2 (proximal) which generate distinct protein isoforms. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE68958

ID:: 200068958

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20023148617.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL24676
156 Samples

Download data: BW

Series

Accession:: GSE231486

ID:: 200231486

PubMed Full text in PMC Similar studies

Select item 20023148518.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [HiC]

(Submitter supplied) Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate their differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - has been shown to bind to regulatory elements in bulk CD34+ HSPCs. However, whether specific combinations of these TFs have distinct roles in regulating hematopoietic differentiation remained unknown. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
8 Samples

Download data: BED, MATRIX

Series

Accession:: GSE231485

ID:: 200231485

PubMed Full text in PMC Similar studies

Select item 20023142619.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [HiChIP]

(Submitter supplied) Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate their differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - has been shown to bind to regulatory elements in bulk CD34+ HSPCs. However, whether specific combinations of these TFs have distinct roles in regulating hematopoietic differentiation remained unknown. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE231426

ID:: 200231426

PubMed Full text in PMC Similar studies

Select item 20023142520.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [ChIP-seq]

(Submitter supplied) Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate their differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - has been shown to bind to regulatory elements in bulk CD34+ HSPCs. However, whether specific combinations of these TFs have distinct roles in regulating hematopoietic differentiation remained unknown. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: BW

Series

Accession:: GSE231425

ID:: 200231425

PubMed Full text in PMC Similar studies

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