Similar studies for GEO DataSets (Select 200131748) - GEO DataSets

Select item 2001317481.

Expression data form P90 mouse hippocampus - various mutant condition

(Submitter supplied) The level of Synaptotagmin-2 (Syt2) was altered by deletion of IPMK protein in the male mouse brain. We investigated gene expression changes in the hippocampal region of IPMK conditional knockout (cKO) mice by performing genome-wide transcriptome analyses. In this dataset, we include the expression data obtained from dissected mouse hippocampus using loss-of-function IPMK mutants. These data are used to obtain 5 genes that are differentially expressed in response to IPMK signaling

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
4 Samples

Download data: CEL, XLSX

Series

Accession:: GSE131748

ID:: 200131748

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Select item 2000496582.

Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity

(Submitter supplied) Messenger (m)RNA export from the nucleus is essential for eukaryotic gene expression. Here, we identify a transcript-selective nuclear export mechanism affecting certain human transcripts, enriched for functions in genome duplication and repair, controlled by inositol polyphosphate multikinase (IPMK), an enzyme catalyzing inositol polyphosphate and phosphoinositide turnover. We studied transcripts encoding RAD51, a protein essential for DNA repair by homologous recombination (HR), to characterize the mechanism underlying IPMK-regulated mRNA export. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
12 Samples

Download data: TXT

Series

Accession:: GSE49658

ID:: 200049658

Select item 2002002843.

Intestinal epithelial inositol polyphosphate multikinase protects mice from experimental colitis via governing colonic tuft cell homeostasis

(Submitter supplied) Intestinal homeostasis is dynamically coordinated by various types of epithelial cells fulfilling their specific functions. Tuft cells as chemosensory cells have emerged as key players of the host response, such as innate immunity. Tuft cells are also critical for the restoration of intestinal architecture upon damage, thereby contributing to inflammatory bowel diseases (IBDs) characterized by defective intestinal barrier integrity. more...