Similar studies for GEO DataSets (Select 200133327) - GEO DataSets

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Items: 19

Select item 2001333271.

Chromatin response to hypoxia in MCF7 cells

(Submitter supplied) Oxygen is essential for cell growth, however in tumours quick growth can cause hypoxic conditions. To determine the changes in the chromatin landscape in response to hypoxia in breast cancer we have performed ATAC-seq dugin normoxia and hypoxia.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: BW

Series

Accession:: GSE133327

ID:: 200133327

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001340382.

Single cell sequencing identifies novel sub-populations of breast cancer cells selected under hypoxia

(Submitter supplied) During tumour growth cancer cells are subject to and selected by microenvironmental stress. The selection of such cells allows for continued growth and survival, during hypoxia, acidosis, nutritional deprivation, drug treatment and radiation. However, there is great microenvironmental heterogeneity in every tumour. Must studies of gene regulation in vitro investigate whole cell populations, often by western blotting or mRNA expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
384 Samples

Download data: TSV

Series

Accession:: GSE134038

ID:: 200134038

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Select item 2001824463.

Two ISREs functioning cooperatively regulate ISG expression in West Nile virus infected IFNAR-/- MEFs

(Submitter supplied) We previously identified a subset of interferon stimulated genes (ISGs), including Irf7, Irf1, Oas1a and Oas1b, upregulated by a West Nile virus (WNV) infection in wildtype mouse embryo fibroblasts (MEFs) after viral proteins had inhibited type 1 interferon (IFN)-mediated JAK-STAT signaling and also in WNV-infected STAT1-/-, STAT2-/-, IFNAR-/-, IRF3-/-, IRF7-/-, and IRF3/7-/- MEFs. In this study, ISG upregulation by WNV infection was inhibited in RIG-I/MDA5-/- but not in single knockout MEFs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
12 Samples

Download data: XLSX

Series

Accession:: GSE182446

ID:: 200182446

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Select item 2000437104.

Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
62 Samples

Download data: CEL

Series

Accession:: GSE43710

ID:: 200043710

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Select item 2000437095.

Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC), from both wild-type and MAVS-/- mice

(Submitter supplied) We used microarrays to detail the global programme of gene expression in response to Influenza A (PR8) infection

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE43709

ID:: 200043709

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Select item 2000437086.

Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC), from wild-type, IFNAR1-/-, IL28Ra-/- and IFNAR1-/- IL28Ra-/- double ko

(Submitter supplied) We used microarrays to detail the global programme of gene expression in response to Influenza A (PR8) infection

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
40 Samples

Download data: CEL, TXT

Series

Accession:: GSE43708

ID:: 200043708

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Select item 2000437077.

Expression data from Influenza A infected mouse primary tracheal epithelial cell cultures (MTEC)

(Submitter supplied) We used microarrays to detail the global programme of gene expression in response to Influenza A (PR8) infection

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
10 Samples

Download data: CEL, TXT

Series

Accession:: GSE43707

ID:: 200043707

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Select item 2001125328.

Protein ISGylation regulated gene expression in mouse mammary epithelial cells

(Submitter supplied) Purpose: The goals of this study are to use RNA-seq to identify genes whose expression are regulated by protein ISGylation in a genome-wide scale Methods: mRNA profiles of PyVmT/Uba7 KO + Control and PyVmT/Uba7 KO+UBE1L mammary epithelial cells (MECs) were generated by deep-sequecing in duplicates, using Illumina HiSeq4000. Results: Using an optimized data analysis workflow, we mapped about 25 million sequence reads per sample to the mouse genome (M16 genome annotation). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: XLSX

Series

Accession:: GSE112532

ID:: 200112532

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Select item 2001292939.

Regulation of hypoxia-inducible factor activity by CHD4

(Submitter supplied) CHD4 coactivates a subset of HIF target genes in breast cancer MDA-MB-231 cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
8 Samples

Download data: TXT

Series

Accession:: GSE129293

ID:: 200129293

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Select item 20004135510.

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling

(Submitter supplied) Myeloid dendritic cells from WT, Irf3-/-xIrf7-/-, Irf3-/-xIrf5-/-xIrf7-/-, Mavs-/- (IPS1-/-)and Ifnar-/- mice were infected with West Nile virus to assess the contributions of specific signaling and transcription factors in initiating the antiviral response

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
29 Samples

Download data: TXT

Series

Accession:: GSE41355

ID:: 200041355

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Select item 20016414111.

MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer

(Submitter supplied) Immune checkpoint inhibitors (ICIs) have had a profound impact on the treatment of many tumors; however, their effectiveness against triple-negative breast cancers (TNBCs) has been limited. One factor limiting responsiveness of TNBCs to ICIs is a lack of functional tumor i-infiltrating lymphocytes (TILs) in ‘“non-inflamed’” or ‘“cold’” tumor immune microenvironments (TIMEs), albeitalthough by unknown mechanisms. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: CSV

Series

Accession:: GSE164141

ID:: 200164141

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Select item 20004536212.

miR-18a modulates gene transcription in breast cancer cells treated with Cobalt(II) chloride

(Submitter supplied) Using the orthotopic breast cancer xenograft model of basal-like breast cancer MDA-MB-231 line, we have found that the expression of miRNAs encoded by MIR17HG was significantly decreased in cells isolated from spontaneous lung metastases compared to cells from primary tumors grown in orthotopic sites. We investigated the role of a MIR17HG family member, miR-18a, in primary tumor growth and pulmonary metastasis from the orthotopic site. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE45362

ID:: 200045362

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Select item 20013618113.

Tet-ZFP36L1 in 6 hours and 24 hours

(Submitter supplied) ZFP36L1 is a tandem zinc-finger RNA-binding protein that recognizes conserved Adenylate-Uridylate-rich Elements (AREs) located in 3' untranslated regions (UTRs) to mediate RNA decay. We hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involved in the RNA half-life regulation of cancer-related transcripts. Forced expression of ZFP36L1 in cancer cells markedly reduced cell proliferation in vitro and in vivo; whereas silencing of ZFP36L1 enhanced tumor cell growth. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
6 Samples

Download data: TSV

Series

Accession:: GSE136181

ID:: 200136181

Select item 20013618014.

Silencing of ZFP36L1 using siRNA

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
2 Samples

Download data: TXT

Series

Accession:: GSE136180

ID:: 200136180

Select item 20013617915.

RNA pull down assay of GST-ZFP36L1 (wildtype and mutant)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
3 Samples

Download data: TSV

Series

Accession:: GSE136179

ID:: 200136179

Select item 20012080816.

Genome-wide collaboration of canonical and non-canonical STAT1 complexes with NF-κB to control signal integration between Interferons and TLR4 in vascular and immune cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
111 Samples

Download data: TDF

Series

Accession:: GSE120808

ID:: 200120808

PubMed Full text in PMC Similar studies

Select item 20012080717.

Genome-wide collaboration of canonical and non-canonical STAT1 complexes with NF-κB to control signal integration between Interferons and TLR4 in vascular and immune cells [RNA-seq]

(Submitter supplied) Atherosclerosis is a disease of large and medium-sized muscular arteries and is characterized by vascular inflammation and lipid-laden plaque formation within the intima of the vessel wall. Atherosclerosis is initiated by recruitment of blood leukocytes to the injured vascular endothelium and leads to altered contractility of Vascular Smooth Muscle Cells (VSMCs), acute and chronic luminal obstruction, abnormalities of blood flow and diminished oxygen supply to target organs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
81 Samples

Download data

Series

Accession:: GSE120807

ID:: 200120807

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Select item 20012080618.

Genome-wide collaboration of canonical and non-canonical STAT1 complexes with NF-κB to control signal integration between Interferons and TLR4 in vascular and immune cells [ChIP-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
30 Samples

Download data: TDF

Series

Accession:: GSE120806

ID:: 200120806

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011312319.

Detection of differentially-expressed genes in mouse embryonic fibroblasts (WT, MAVSko, STINGko, and LGP2ko MEFs) following exposure to ionizing radiation

(Submitter supplied) Analysis of the impact of MAVS, STING, and LGP2 in MEFs in response to ionizing radiation at the gene expression level. Results provide important information on the relative contribution to cellular funtions of each individual gene knock-outs in MEFs both at the basal level and in response to genotoxic stress.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
16 Samples

Download data: TXT

Series

Accession:: GSE113123

ID:: 200113123

PubMed Full text in PMC Similar studies Analyze with GEO2R

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