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Links from GEO DataSets

Items: 14

1.

Targeting p16-induced Senescence Prevents Cigarette Smoke-Induced Emphysema by Promoting IGF1/Akt1 Signaling in mice

(Submitter supplied) Increased IGF1 signaling in p16 -/- lungs
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL26852
4 Samples
Download data: XLSX
Series
Accession:
GSE133380
ID:
200133380
2.

Transcriptomic analysis of lung tissue from cigarette smoke induced emphysema murine models and human COPD show shared and distinct pathways

(Submitter supplied) Although cigarette smoke (CS) is the primary risk factor for COPD, the underlying molecular mechanisms for the significant variability in developing COPD in response to CS are incompletely understood. We performed lung gene expression profiling of two different wild-type murine strains (C57BL/6J, NZW/LacJ) and two genetic models with mutations in COPD GWAS genes (HHIP, FAM13A) after 6 months of chronic CS exposure and compared the results to human COPD lung tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
109 Samples
Download data: TXT
Series
Accession:
GSE87292
ID:
200087292
3.

Analysis of lung transcriptomic changes following inhibition of LTβR-signalling in cigarette smoke exposed mice

(Submitter supplied) How LTβR-signalling drives chronic tissue damage particularly in the lung, which mechanisms regulate this process, and whether LTβR-blockade might be of therapeutic value has remained unclear. To study the mechanisms underlying LTβR-inhibition, a transcriptional analysis was performed on lung tissue from B6 mice exposed to cigarette smoke for 6 months and treated therapeutically with LTβR-Ig from 4 to 6 months compared to mice exposed to cigarette smoke for 6 months and treated with control Ig from 4 to 6 months and filtered air control. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
13 Samples
Download data: MTX, TXT
Series
Accession:
GSE151674
ID:
200151674
4.

Inhibition of LTβR-signalling blocks epithelial apoptosis and activates endogenous Wnt-induced regeneration

(Submitter supplied) Lymphotoxin β-receptor-signalling orchestrates lymphoid neogenesis and subsequent tertiary lymphoid structures (TLS) associated with severe chronic inflammatory diseases spanning multiple organ systems. How LTβR-signalling drives chronic tissue damage particularly in the lung, which mechanism(s) regulate this process, and whether LTβR-blockade might be of therapeutic value has remained unclear. Here we demonstrate increased lymphotoxin expression of LTbR-ligands on myeloid and adaptive and innate immune-cells, enhanced non-canonical NF-κB signalling and enrichment of LTβR-target gene expression in epithelial cells of lungs from patients and mice with smoking-associated chronic obstructive pulmonary disease (COPD). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
27 Samples
Download data: TXT
Series
Accession:
GSE125521
ID:
200125521
5.

RNA profiling of p16ink4a-expressing pancreatic beta-cells

(Submitter supplied) Transcriptome of beta-cells isolated from mice expressing p16ink4a and GFP transgenes and of control β-cells isolated from mice expressing only the GFP transgene
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
5 Samples
Download data: TXT
Series
Accession:
GSE76992
ID:
200076992
6.

Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model

(Submitter supplied) TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8389
20 Samples
Download data: TXT
Series
Accession:
GSE33561
ID:
200033561
7.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic association studies, with IRP2 increased in the lungs of COPD patients. Here we demonstrate that mice deficient in IRP2 are protected from cigarette smoke (CS)-induced COPD. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: TXT
Series
Accession:
GSE57073
ID:
200057073
8.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading.

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic association studies, with IRP2 increased in the lungs of COPD patients. Here we demonstrate that mice deficient in IRP2 are protected from cigarette smoke (CS)-induced COPD. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17777
11 Samples
Download data: CEL
Series
Accession:
GSE57048
ID:
200057048
9.

Comparative analysis of gene expression in A/J CS vs Air lungs.

(Submitter supplied) We hypothesize that gene expression in the CS-exposed lungs of this strain (A/J) of mice would be able to give clues about the molecular mechanism of emphysema development, thus contributing to this phenotype. More specifically, although imbalance in oxidants/antioxidants and proteinase/antiproteinase pathways drives the pathogenesis of COPD, the molecular mechanisms involved in the development of emphysema are poorly understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3548
Platform:
GPL1261
22 Samples
Download data: CEL, EXP
Series
Accession:
GSE8790
ID:
200008790
10.
Full record GDS3548

Cigarette smoke-induced pulmonary emphysema model

Analysis of lungs of A/J animals exposed to cigarette smoke (CS) for up to 6 months. A/J animals chronically exposed to CS develop pulmonary emphysema (PE). Results provide insight into the molecular mechanisms underlying the initiation and development of PE.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL1261
Series:
GSE8790
22 Samples
Download data: CEL, EXP
11.

Gene expression data from IMR90 control, IMR90 shRRM2 and shRRM2/shp16

(Submitter supplied) Transformed and tumorigenic cells require increased deoxyribonucleotide synthesis to fuel the genome replication that sustains their unregulated cell cycle and proliferation. Therefore, it is likely that the cell cycle and nucleotide metabolism are linked. The cell cycle inhibitor p16 is a critical tumor suppressor that is lost as an early event in many human cancers. While loss of p16 is known to play a role in deregulating the cell cycle, whether loss of p16 expression affects nucleotide metabolism is unknown.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
9 Samples
Download data: TXT
Series
Accession:
GSE133660
ID:
200133660
12.

Histone modifications in lung epithelial cells

(Submitter supplied) We report histone modifications in alveolar epithelial type 2 cells in homeostatic mice as well as CTGF-positive alveolar eptihelial cells in mice treated with Bleomycin.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL21273 GPL24247
20 Samples
Download data: BED, BEDGRAPH
Series
Accession:
GSE141635
ID:
200141635
13.

single-cell RNA-seq in alveolar organoids cultured in MTECplus medium

(Submitter supplied) We performed Drop-seq using alveolar organoids cultured in MTECplus medium to identify cell types, gene expression patterns and signaling pathways in ex vivo condition.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
1 Sample
Download data: TSV
Series
Accession:
GSE141634
ID:
200141634
14.

Single cell RNAseq analysis of mouse lung after irradiation

(Submitter supplied) Thoracic radiation therapy is limited by the development of acute (i.e. pneumonitis) and late (i.e. pulmonary fibrosis) side-effects. The goal of this study is to analyze, at the single cell level, the molecular impact of two radiation treatments : a conventional/clinical (CONV) modality vs. FLASH, a new radiation method that spares healthy tissue from late radiation-induced toxicities (Science Translational Medicine 6: 245ra293, 2014). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
3 Samples
Download data: MTX, TSV
Series
Accession:
GSE133992
ID:
200133992
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