Similar studies for GEO DataSets (Select 200134167) - GEO DataSets

Select item 2001341671.

Stat6 occupancy profiling by high throughput sequencing from wild-type(WT) or Trim24-deficient(Trim24-KO) mouse peritoneal macrophages stimulated with IL-4 for 1 hour .

(Submitter supplied) To identify the potential genes that regulated by Trim24 through Stat6 DNA binding activity, we immunoprecipitated chromatin from WT or Trim24-KO macrophages stimulated with IL-4, and analyzed the precipitated DNA with deep sequencing (ChIP-Seq).

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
3 Samples

Download data: BW

Series

Accession:: GSE134167

ID:: 200134167

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001341582.

Expression data from wild-type and TIF1a-knockout mouse macrophages stimulated with or without mouse IL-4(20ng/mL) for 6 h.

(Submitter supplied) We conducted gene expression profile analysis by using wild-type and TIF1a-knockout peritoneal macrophage.Analysis revealed the most prominent different expression of genes altered in macrophages upon IL-4 stimulation were associated with marker genes of alternative macrophage.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: XLS

Series

Accession:: GSE134158

ID:: 200134158

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Select item 2001165883.

Expression data from wild-type peritoneal macrophages (termed WTPM) non-treated (NT) or stimulated for 6 h with mouse IL-4.

(Submitter supplied) We conducted gene expression profile analysis by using wild-type peritoneal macrophages(termed WTPM).Scatter diagram revealed the most prominent different expression of genes altered in macrophages upon IL-4 stimulation were associated with M2 macrophage and Trims genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
2 Samples

Download data: XLS

Series

Accession:: GSE116588

ID:: 200116588

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Select item 2001165664.

Expression data from WT and Trim24-deficient tumor-associated macrophage(TAM) sorted from B16 bearing mouse

(Submitter supplied) We conducted gene expression profile analysis by using CD45+ CD11b+ F4/80+ TAM sorted from WT or Trim24-deficient B16 bearing mouse.Scatter diagram revealed the most prominent different expression of genes altered in TAM were associated with M2 genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TXT

Series

Accession:: GSE116566

ID:: 200116566

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Select item 2001067065.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
141 Samples

Download data: TSV

Series

Accession:: GSE106706

ID:: 200106706

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Select item 2001067056.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TSV

Series

Accession:: GSE106705

ID:: 200106705

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Select item 2001067047.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq II]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
53 Samples

Download data: TSV

Series

Accession:: GSE106704

ID:: 200106704

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Select item 2001067038.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [GRO-Seq]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TSV

Series

Accession:: GSE106703

ID:: 200106703

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001067029.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ATAC-Seq]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TSV

Series

Accession:: GSE106702

ID:: 200106702

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670110.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [ChIP-Seq I]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
64 Samples

Download data: TSV

Series

Accession:: GSE106701

ID:: 200106701

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010670011.

Characterization of transcriptional and epigenetic changes during mouse alternative macrophage polarization [RNA-Seq I]

(Submitter supplied) The molecular basis of signal-dependent transcriptional activation has been extensively studied in macrophage polarization, however our understanding remains limited regarding the molecular determinants of repression. Here we showed that IL-4-activated STAT6 transcription factor is required for the direct transcriptional repression of a large number of genes during mouse alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV

Series

Accession:: GSE106700

ID:: 200106700

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Select item 20010023712.

Gene expression profile of peroxisome proliferator-activated receptor delta (Ppard)-overexpressing RAW 264.7 macrophages treated vehicle, GW501516 or interleukin-4 (Il-4)

(Submitter supplied) Investigation of whole genome gene expression level changes in GW501516 (a Ppard ligand) or Il-4 treated Ppard-overexpressing RAW 264.7 macrophages as compared to vehicle. Alternative activation of adipose tissue resident macrophages inhibits obesity-induced metabolic inflammation. In the current study we profile genes regulated by two M2 inducers, Il-4 or Ppard agonists and find that alternative activation promotes the cell survival program, while inhibiting that of inflammation-related cell death.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10192
9 Samples

Download data: PAIR

Series

Accession:: GSE100237

ID:: 200100237

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010797913.

Identifying lncRNAs as novel modulators of macrophage M2 polarization

(Submitter supplied) By utilizing a series of specific modulating M2 macrophages polarization models, 3872 up-regulated and 3091 down-regulated genes were found during the polarization process.

Organism:: Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL24378
2 Samples

Download data: GPR

Series

Accession:: GSE107979

ID:: 200107979

Select item 20010795214.

Identifying lncRNA-MM2P as a novel modulator of macrophage M2 polarization

(Submitter supplied) By utilizing a series of specific modulating M2 macrophages polarization models, 1556 up-regulated and 953 down-regulated genes were found during the polarization process.

Organism:: Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL24373
4 Samples

Download data: GPR

Series

Accession:: GSE107952

ID:: 200107952

Select item 20013636315.

Expression data from wild-type bone marrow-derived macrophages non-treated (NT1 and NT2) or stimulated for 12 h with VSV virus(VSV1 and VSV2)

(Submitter supplied) We conducted gene expression profile analysis by using wild-type bone marrow-derived macrophages. Heatmap revealed the most prominent different expression of genes encoding E3 ligases or DUBs altered in macrophages upon VSV stimulation were associated with typeⅠIFN genes.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TXT

Series

Accession:: GSE136363

ID:: 200136363

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015101516.

The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the stable epigenomic program of alternative macrophage polarization

(Submitter supplied) Macrophages polarize into functionally distinct subtypes while responding to microenvironmental cues. The identity of proximal transcription factors (TFs) downstream of the polarization signals are known, but their activity is typically transient, failing to explain the long-term, stable epigenomic programs developed. Here, we mapped the early and late epigenomic changes of interleukin-4 (IL-4)-induced alternative macrophage polarization. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
72 Samples

Download data: BW, TXT

Series

Accession:: GSE151015

ID:: 200151015

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002185317.

Gene expression analysis of IL-4 primed bone marrow macrophages isolated from Irf4-deficient or heterozygous mice

(Submitter supplied) To analyse the Irf4-dependent transcriptional changes of mouse bone marrow-derived macrophages (BMM) in response to IL-4, we have employed whole genome microarray expression profiling. For this purpose, bone marrow cells were isolated from 8 to 12 weeks old Irf4-deficient or heterozygous mice and cultured in the presence of the macrophage colony-stimulating factor (M-CSF) . After seven days of culture, IL-4 was added for 4 and 18 hours. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4134
18 Samples

Download data: TXT

Series

Accession:: GSE21853

ID:: 200021853

Select item 20010088918.

Extensive overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte-derived differentiating macrophages

(Submitter supplied) Macrophages are able to differentiate into classically polarized (M1) or alternatively polarized (M2) states upon encountering pro-inflammatory cytokines such as interferon (IFN) g or anti-inflammatory cytokines such as interleukin (IL) -4/IL-13, respectively. Moreover, macrophages are known to regulate lipid metabolism via multiple members of the nuclear hormone receptor family, including the retinoid X receptors (RXR). more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: TXT

Series

Accession:: GSE100889

ID:: 200100889

PubMed Similar studies SRA Run Selector

Select item 20013954119.

Transcriptional analysis of transcription factor c-Maf as a molecular switch that controls immune suppression by programming macrophages in lung cancer

(Submitter supplied) To investigate c-Maf-controlled gene expression, M2-like bone marrow-derived macrophages (BMM) were transfected with c-Maf or control siRNA. Knockdown of c-Maf significantly decreased c-Maf protein and mRNA expression levels. In addition, IL-10 and arginase mRNA levels were significantly decreased while IL-12 was increased. In contrast, ectopic expression of c-Maf in the M1-like BMM significantly upregulated IL-10 and arginase mRNA expression levels while downregulated IL-12 expression level, suggesting an M2-like phenotype. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
6 Samples

Download data: TXT

Series

Accession:: GSE139541

ID:: 200139541

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013903920.

C-maf binding to dna in C-maf_ab vs Iso in Mus musculus

(Submitter supplied) We report the application of Chip-seq to study the binding properties of C-maf. We determine the genetic and non genetic regions with the largest Chip-seq peaks in C-maf_ab compared to Isotype control antibody (Iso) samples.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL23479
5 Samples

Download data: BW, TXT

Series

Accession:: GSE139039

ID:: 200139039

PubMed Full text in PMC Similar studies SRA Run Selector

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