Similar studies for GEO DataSets (Select 200144168) - GEO DataSets

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Items: 2

Select item 2001441681.

Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach

(Submitter supplied) Background: Blood-retinal barrier cells are known to exhibit a massive phenotypic change during experimental autoimmune uveitis (EAU) development. In an attempt to investigate the mechanisms of blood-retinal barrier (BRB) breakdown at a global level, we studied the gene regulation of total retinal cells and retinal endothelial cells during non-infectious uveitis. Methods: Retinal endothelial cells were isolated by flow cytometry either in Tie2-GFP mice (CD31+ CD45- GFP+ cells), or in wild type C57BL/6 mice (CD31+ CD45- endoglin+ cells). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
16 Samples

Download data: XLSX

Series

Accession:: GSE144168

ID:: 200144168

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000196522.

Effector T cells driving monophasic vs relapse/remitting experimental autoimmune uveitis show unique pathway signatures

(Submitter supplied) Experimental autoimmune uveitis (EAU) in Lewis rats is a model for the clinical heterogeneity of human uveitis. The autoantigens inducing disease in the rat are also seen in human disease. Depending upon the specific autoantigen used, the experimental disease course can be either monophasic or relapsing/remitting and appears to be dictated by the T cell effector phenotype elicited. We investigated potential differences between monophasic and relapsing/remitting effector T cells using transcriptomic profiling and pathway analysis. more...