Similar studies for GEO DataSets (Select 200145921) - GEO DataSets

Select item 2001459211.

Genomic and transcriptomic analysis of medulloblastoma

(Submitter supplied) Identification of transcriptomic and genomic changes by RNA-seq, ATAC-seq and low coverage WGS in mouse and human tumor cells

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing

Platforms:: GPL16791 GPL17021
33 Samples

Download data: BED, BW, CSV, TXT

Series

Accession:: GSE145921

ID:: 200145921

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000341262.

An Animal Model of Myc-driven medulloblastoma

(Submitter supplied) Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of the disease. Here we show that cerebellar stem cells expressing Myc and mutant Trp53 (p53) generate aggressive tumors following orthotopic transplantation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4478
Platform:: GPL1261
19 Samples

Download data: CEL

Series

Accession:: GSE34126

ID:: 200034126

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 44783.

MYC-driven medulloblastoma model

Analysis of Myc/DNp53-infected tumors derived from stem cells or progenitors, uninfected stem cells, and patched tumor cells. Cerebellar stem cells expressing Myc and mutant Trp53 generate tumors similar to MYC-driven medulloblastoma (MB). Results provide insight into transformation to MB tumor.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 4 cell type, 3 genotype/variation, 4 other sets

Platform:: GPL1261
Series:: GSE34126
19 Samples

Download data: CEL

DataSet

Accession:: GDS4478

ID:: 4478

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000626264.

Combined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL6885 GPL13534
88 Samples

Download data: IDAT

Series

Accession:: GSE62626

ID:: 200062626

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000626255.

Combined MYC and TP53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease [gene expression]

(Submitter supplied) We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive disease post-relapse. To study this genetic interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
48 Samples

Download data: IDAT, TXT

Series

Accession:: GSE62625

ID:: 200062625

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000626186.

Methylation data from presentation and relapsed medulloblastoma tumour samples

(Submitter supplied) We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC gene family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this molecular group died of rapidly progressive disease post-relapse. To study this genetic interaction, we investigated a transgenic model of MYCN-driven medulloblastoma and found spontaneous development of Trp53 inactivating mutations. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
40 Samples

Download data: CSV

Series

Accession:: GSE62618

ID:: 200062618

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001392407.

ARF suppression by MYC but not MYCN confers increased malignancy of Group 3 medulloblastoma

(Submitter supplied) Group 3 medulloblastoma (MB) carries the worst prognosis of the four molecular subgroups of MB. MYC amplifications represent the most common genetic alteration in Group 3 MB. By specifically driving MYC in hindbrain cells using a Tet-OFF system, we established a novel murine model of MB (GMYC) that accurately recapitulates human Group 3 MB. GMYC tumours develop with 60-70% penetrance, without p53 mutations, and are monoclonal as revealed by multicolour cell fate tracing. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL27583 GPL16331
32 Samples

Download data: TXT

Series

Accession:: GSE139240

ID:: 200139240

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001147608.

Remodeling Group 3 medulloblastoma: MYC overexpression alone transforms progenitors of astrocytes and granule neurons in the postnatal cerebellum

(Submitter supplied) Group 3 medulloblastoma is often associated with MYC amplification or overexpression, while whether MYC overexpression alone is sufficient to induce tumorigenesis is unknown and the cell type(s) which can be transformed by MYC is unclear. Here, by generating a new mouse model, we demonstrated that overexpression of Myc alone is sufficient to transform astrocyte progenitors and granule neuron progenitors (GNP) in the early postnatal cerebellum following orthotopic transplantation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
21 Samples

Download data: TXT

Series

Accession:: GSE114760

ID:: 200114760

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000211669.

The miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehog–Treated Cerebellar Neural Precursors

(Submitter supplied) Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution single-nucleotide polymorphism genotyping arrays and subsequent interphase fluorescence in situ hybridization on a human medulloblastoma tissue microarray. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
90 Samples

Download data: CEL

Series

Accession:: GSE21166

ID:: 200021166

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003320110.

A mouse model of the most aggressive subgroup of human medulloblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL11180 GPL1261
79 Samples

Download data: CEL

Series

Accession:: GSE33201

ID:: 200033201

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003320011.

A mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM]

(Submitter supplied) A series of mouse models designed to mimic pediatric medulloblastoma types in humans were tested by microarray and compared to published human medulloblastoma data

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
15 Samples

Download data: CEL

Series

Accession:: GSE33200

ID:: 200033200

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003319912.

A mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]

(Submitter supplied) Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
64 Samples

Download data: CEL

Series

Accession:: GSE33199

ID:: 200033199

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000646313.

Genetic alterations in mouse medulloblastomas and generation of tumors from cerebellar grunule neuron precursors

(Submitter supplied) Mice lacking p53 and one or two alleles of the cyclin D-dependent kinase inhibitor p18Ink4c are prone to medulloblastoma development. The tumor frequency is increased by exposing postnatal animals to ionizing radiation at a time when their cerebella are developing. In irradiated mice engineered to express a floxed p53 allele and a Nestin-Cre transgene, tumor development can be restricted to the brain. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL339 GPL340
10 Samples

Download data: CEL

Series

Accession:: GSE6463

ID:: 200006463

Select item 20012097414.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
30 Samples

Download data: FPKM_TRACKING, MTX, TSV, TXT, WIG

Series

Accession:: GSE120974

ID:: 200120974

PubMed Full text in PMC Similar studies

Select item 20012097315.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma [RNA-Seq]

(Submitter supplied) By utilizing single-cell analysis at different stages of tumorigenesis, we demonstrated a developmental hierarchy of dynamic progenitor pools in murine sonic hedgehog-(SHH) MBs. We identified Olig2+ progenitors as transit-amplifying cells during initial tumorigenic phases. These cells are quiescent stem-like progenitors in full-blown tumors but enriched in therapy-resistant as well as recurrent medulloblastomas. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
16 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE120973

ID:: 200120973

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012097216.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma [Drop-Seq]

(Submitter supplied) By utilizing single-cell analysis at different stages of tumorigenesis, we demonstrated a developmental hierarchy of dynamic progenitor pools in murine sonic hedgehog-(SHH) MBs. We identified Olig2+ progenitors as transit-amplifying cells during initial tumorigenic phases. These cells are quiescent stem-like progenitors in full-blown tumors but enriched in therapy-resistant as well as recurrent medulloblastomas. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE120972

ID:: 200120972

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012096817.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma [ChIP-Seq]

(Submitter supplied) By utilizing single-cell analysis at different stages of tumorigenesis, we demonstrated a developmental hierarchy of dynamic progenitor pools in murine sonic hedgehog-(SHH) MBs. We identified Olig2+ progenitors as transit-amplifying cells during initial tumorigenic phases. These cells are quiescent stem-like progenitors in full-blown tumors but enriched in therapy-resistant as well as recurrent medulloblastomas. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
9 Samples

Download data: WIG

Series

Accession:: GSE120968

ID:: 200120968

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012096718.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma [ATAC-Seq]

(Submitter supplied) By utilizing single-cell analysis at different stages of tumorigenesis, we demonstrated a developmental hierarchy of dynamic progenitor pools in murine sonic hedgehog-(SHH) MBs. We identified Olig2+ progenitors as transit-amplifying cells during initial tumorigenic phases. These cells are quiescent stem-like progenitors in full-blown tumors but enriched in therapy-resistant as well as recurrent medulloblastomas. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: WIG

Series

Accession:: GSE120967

ID:: 200120967

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012096619.

Single-cell RNA-seq Reveals a Developmental Hierarchy and Oncogenic Networks for Initiation of Medulloblastoma [10x Genomics Chromium]

(Submitter supplied) By utilizing single-cell analysis at different stages of tumorigenesis, we demonstrated a developmental hierarchy of dynamic progenitor pools in murine sonic hedgehog-(SHH) MBs. We identified Olig2+ progenitors as transit-amplifying cells during initial tumorigenic phases. These cells are quiescent stem-like progenitors in full-blown tumors but enriched in therapy-resistant as well as recurrent medulloblastomas. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE120966

ID:: 200120966

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016208020.

Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma

(Submitter supplied) Tumor recurrence is a slow biological process involving therapy resistance, immune escape and metastasis and is the leading cause of death in medulloblastoma, the most frequent malignant pediatric brain tumor. By studying paired primary-recurrent patient samples and patient-derived xenografts we identified significant accumulation of SOX9-positive cells in relapses and metastases. They exist as rare, quiescent cells in Group 3 and Group 4 patients that constitute two thirds of medulloblastoma. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16331 GPL24247
44 Samples

Download data: TXT

Series

Accession:: GSE162080

ID:: 200162080

PubMed Full text in PMC Similar studies SRA Run Selector

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