GEO DataSets

(Submitter supplied) Structural data of genome organization in somatic cells (fibroblasts) and germ cells (primary spermatocytes and round spermatids) from wild mice with Rb fusions from the Barcelona Rb System.

Organism:

Mus musculus domesticus

Type:

Other

Platform:

GPL17637

3 Samples

Download data: H5

(Submitter supplied) Here we generated a high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ Hi-C, RNA-seq and ChIP-seq of CTCF and meiotic cohesins RAD21L and REC8.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL19057 GPL13112

18 Samples

Download data: BW, TSV, TXT

(Submitter supplied) The Drosophila gene dany is expressed specifically in spermatocytes and encodes a nuclear protein with similarity to the products of the genes distal antenna (dan) and distal antenna-related (danr). Loss of dany function results in male sterility. Mutant spermatocytes fail to differentiate similar as previously observed in mutants lacking tTAF and tMAC function. Microarray analyses were performed to characterize the effects of loss of dany function on gene expression in testis and for a comparison of the effects with those caused by mutations in the tTAF gene spermatocyte arrest (sa) and the tMAC genes always early (aly) and matotopetli (topi)

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL17080

13 Samples

Download data: TXT

(Submitter supplied) Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recurrent pregnancy loss in humans, we performed expression profiling of male and female gonads of mice undergoing meiotic prophase I.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4503

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of gonads from fetal, neonatal and adult C57BL/6 males and females. Events during meiosis I prophase are critical for correct segregation of chromosomes. Defects in these events may contribute to infertility. Results provide insight into molecular mechanisms underlying meiosis I prophase.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 tissue sets

Platform:

GPL1261

Series:

GSE35734

6 Samples

Download data: CEL

(Submitter supplied) Here we describe the principles of 3D genome folding dynamics in vertebrates and show how lineage-specific patterns of genome reshuffling can result in different chromatin configurations. We (i) identified different patterns of chromosome folding across vertebrate species, (ii) reconstructed ancestral marsupial and afrotherian genomes analyzing whole-genome sequences of 10 species representative of the major therian phylogroups, (iii) detected lineage-specific chromosome rearrangements and (iv) identified the dynamics of the structural properties of genome reshuffling through therian evolution.

Organism:

Notamacropus eugenii; Orycteropus afer; Sarcophilus harrisii; Loxodonta africana

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

7 related Platforms

15 Samples

Download data: BEDGRAPH, TSV, TXT