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Phase I Dose Escalation Study of ATRA Combined with the LSD1 inhibitor Tranylcypromine in AML and MDS
PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
PubMed Full text in PMC Similar studies Analyze with GEO2R
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]
PubMed Full text in PMC Similar studies SRA Run Selector
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia
Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes
HL-60 cells following treatment with different compounds
PubMed Similar studies
RNA-seq of HL-60 cells following treatment with different compounds
PubMed Similar studies Analyze with GEO2RSRA Run Selector
H3K9 acetylation and di-methylation changes in HL-60 cells following treatment with different compounds
PubMed Similar studies SRA Run Selector
PRAME induced inhibition of retinoic acid receptor signaling-mediated differentiation - a possible target for ATRA response in AML without t(15;17)
PubMed Similar studies Analyze with GEO2R
LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML
Genome-wide CRISPR-Cas9 screen identifies druggable synthetic lethality between LSD1 and MTORC1 in MLL-translocated AML
Targeting the scaffolding role of LSD1(KDM1A) poises acute myeloid leukemia cells for Retinoic Acid induced differentiation
PubMed Full text in PMC Similar studies
Targeting the scaffolding role of LSD1(KDM1A) poises acute myeloid leukemia cells for Retinoic Acid induced differentiation [RNA-seq]
Targeting the scaffolding role of LSD1(KDM1A) poises acute myeloid leukemia cells for Retinoic Acid induced differentiation [ChIP-seq]
Single-cell RNA-seq of AML patient bone marrow treated with INCB059872, azacitidine, or combination
Single-cell RNA-seq: INCB059872 in wild-type murine bone marrow
RNA-seq of murine megakaryocyte progenitor cells treated with LSD1 inhibitor INCB059872
ChIP-seq for histone acetylation and methylation in THP-1 cells treated with LSD1 inhibitor INCB059872
RNA-seq of MV-4-11 or THP-1 cells treated with LSD1 inhibitor INCB059872
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