GEO DataSets

(Submitter supplied) Determining the pathogenicity of human genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands of clinically important genes will likely require generalizable, scalable assays. We previously developed Variant Abundance by Massively Parallel Sequencing (VAMP-seq), which measures the effects of thousands of missense variants of a protein on intracellular abundance in a single experiment. more...

Organism:

Homo sapiens; Escherichia coli

Type:

Other

Platforms:

GPL18573 GPL21222 GPL24462

9 Samples

Download data: CSV

(Submitter supplied) Determining the pathogenicity of human genetic variants is a critical challenge, and functional assessment is often the only option. Experimentally characterizing millions of possible missense variants in thousands of clinically important genes will likely require generalizable, scalable assays. Here we describe Variant Abundance by Massively Parallel Sequencing (VAMP-seq), which measures the effects of thousands of missense variants of a protein on intracellular abundance in a single experiment. more...

Organism:

Homo sapiens; Escherichia coli

Type:

Other

Platforms:

GPL21222 GPL24462 GPL18573

20 Samples

Download data: TSV, XLS

(Submitter supplied) 183 breast tumors from the Helsinki Univerisity Central Hospital with survival information

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

183 Samples

Download data: TXT

(Submitter supplied) Comparison of the tumors PTEN promoter variant carrier and non carrier gene expression profiles.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

20 Samples

Download data: TXT

(Submitter supplied) WAP-Cre:Ptenf/f:p53lox.stop.lox_R270H composite mice were generated by genetic crossing. In these mice, Pten is deleted and a R270H p53 mutation in the DNA binding domain is induced upon expression of Cre recombinase in pregnancy-identified alveolar progenitors. Tumors were characterized by histology, marker analysis, various bioinformatics methods, high-throughput (HTP) FDA-drug screen as well as orthotopic injection to quantify tumor initiating cells (TICs) and tail-vein injection to identify lung-metastasis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

31 Samples

Download data: CEL