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Items: 6

1.

Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways [II]

(Submitter supplied) Disruption of iron metabolism is closely related to metabolic diseases. Iron deficiency is frequently associated with obesity and hepatic steatosis. However, the effects of iron supplementation on obesity and energy metabolism remain unclear. Here we show that a high-fat diet supplemented with iron reduces body weight gain and hepatic lipid accumulation in mice. Iron supplementation was found to reduce mitochondrial morphological abnormalities and upregulate gene transcription involved in mitochondrial function and beta oxidation in the liver and skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL, CHP
Series
Accession:
GSE161646
ID:
200161646
2.

Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways [I]

(Submitter supplied) Disruption of iron metabolism is closely related to metabolic diseases. Iron deficiency is frequently associated with obesity and hepatic steatosis. However, the effects of iron supplementation on obesity and energy metabolism remain unclear. Here we show that a high-fat diet supplemented with iron reduces body weight gain and hepatic lipid accumulation in mice. Iron supplementation was found to reduce mitochondrial morphological abnormalities and upregulate gene transcription involved in mitochondrial function and beta oxidation in the liver and skeletal muscle. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL, CHP
Series
Accession:
GSE161644
ID:
200161644
3.

Comprehensive transcriptomic characterization of hepatic expression signatures affected by guanine nucleotide binding protein (G protein) alpha 12 knockout

(Submitter supplied) Heterotrimeric guanine nucleotide-binding proteins (G proteins) transmit extracellular signals from cell surface G protein-coupled receptors to intracellular effector molecules. Of the G proteins, Gα12 has attracted particular interest as the gep oncogene in cancer research because it promotes the growth and oncogenic transformation of fibroblasts and is invoked in tumorigenesis. In our findings, Gα12 expression was higher in HCC than surrounding non-tumorous tissue. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
6 Samples
Download data: TXT
Series
Accession:
GSE51694
ID:
200051694
4.

Malnutrition-associated hepatic steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction and rescued by fenofibrate

(Submitter supplied) Severe malnutrition in young children is associated with signs of hepatic dysfunction such as steatosis and hypoalbuminemia, but its etiology is unknown. To investigate the underlying mechanisms of hepatic dysfunction we used a rat model of malnutrition by placing weanling rats on a low protein or control diet (5% or 20% of calories from protein, respectively) for four weeks. Low protein diet-fed rats developed hypoalbuminemia and severe hepatic steatosis, consistent with the human phenotype. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL11534
24 Samples
Download data: CEL
Series
Accession:
GSE63096
ID:
200063096
5.

Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis

(Submitter supplied) Abstract: Obesity characterized by adiposity and ectopic fat accumulation is associated with the development of non-alcoholic fatty liver disease (NAFLD). Treatments that stimulate lipid utilization may prevent the development of obesity and comorbidities. This study evaluated the potential anti-obesogenic hepatoprotective effects of combined treatment with L-carnitine and nicotinamide riboside, i.e., components that can enhance fatty acid transfer across the inner mitochondrial membrane and increase nicotinamide adenine nucleotide (NAD+) levels, which are necessary for β-oxidation and the TCA cycle, respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
38 Samples
Download data: TXT
Series
Accession:
GSE136821
ID:
200136821
6.

FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity

(Submitter supplied) To understand the downstream pathways of the Epo signaling, we have emplyed microarray gene expression profiling to discover the gene expression changes in 32D cells upon the Epo stimulation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
4 Samples
Download data: TXT, XLSX
Series
Accession:
GSE113657
ID:
200113657
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