GEO DataSets

(Submitter supplied) To better understand which genes/pathways are activated in injured muscles following a spinal cord injury (SCI) and how these promote the development of neurogenic heterotopic ossification (NHO), we performed gene expression profiling by microarray of muscles in the early phase following muscle injury.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

16 Samples

Download data: IDAT, TXT

(Submitter supplied) Heterotopic Ossification (HO) is the abnormal formation of ectopic bone in soft tissues generally in muscles surrounding joints such hip, knee, elbow or shoulder. The etiology of this pathology is not known but it is well established that the risk of HO is increased after traumatic brain or spinal cord injuries and also after fractures or burns. Patients with HOs suffer from pain and the range of motion from limbs with ectopic bone is highly reduced. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10630

16 Samples

Download data: TXT

(Submitter supplied) Neurogenic heterotopic ossifications are intramuscular bone formations developing following central nervous system injury. The pathophysiology is poorly understood and current treatments for this debilitating condition remain unsatisfying. Here we explored the role of miRNAs in a clinically relevant mouse model that combines muscle and spinal cord injury (SCI), and in patients’ cells. We found an osteo-suppressive miRNAs response in injured muscle that was hindered when the spinal cord injury was associated. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Other

Platform:

GPL33702

8 Samples

Download data: XLSX

(Submitter supplied) We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates its detrimental effect, we analyzed the transcriptome of the injured spinal cord of Il1a-KO, Il1b-KO and C57BL/6 mice at 24 hours after SCI using GeneChip microarrays.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5825

Platform:

GPL6246

12 Samples

Download data: CEL

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE70302

12 Samples

Download data: CEL

(Submitter supplied) Spinal cord injured mice were treated with IL-13, IL-4 or PBS. Populations of macrophages and microglia were sorted and analyzed separately.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

18 Samples

Download data: TXT