Similar studies for GEO DataSets (Select 200167083) - GEO DataSets

(Submitter supplied) The product of the ecotropic virus integration site 1 (EVI1) gene, whose overexpression is associated with a poor prognosis in myeloid leukemias and some epithelial tumors, regulates gene transcription both through direct DNA binding and through modulation of the activity of other sequence specific transcription factors. Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARb gene, but repressed the ATRA induction of the EVI1 gene itself. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5613
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66854

ID:: 200066854

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000668536.

Transcriptional regulation by EVI1 in the absence or presence of TPA

(Submitter supplied) To investigate whether and how expression of the oncogenic transcription factor EVI1 influences gene regulation by phorbol esters and vice versa, the human myeloid cell line U937 was transduced with an EVI1 expression vector or empty vector as a control. Cells were treated with 12-Otetradecanoylphorbol 13-acetate (TPA) or its solvent ethanol as a control. RNA was extracted and subjected to gene expression microarray analysis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66853

ID:: 200066853

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000668377.

The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid [HL60]

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5614
Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE66837

ID:: 200066837

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 56148.

All-trans retinoic acid effect on HL60 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE66837
12 Samples

Download data: CEL

DataSet

Accession:: GDS5614

ID:: 5614

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56139.

All-trans retinoic acid effect on U937 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL570
Series:: GSE66854
12 Samples

Download data: CEL

DataSet

Accession:: GDS5613

ID:: 5613

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20007911010.

Zinc finger protein 521 overexpression is a feature of MLL-rearranged acute myeloid leukemia and contributes to the maintenance of myeloid differentiation block

(Submitter supplied) ZNF521 is a multiple zinc finger transcription factor previously identified because abundantly and selectively expressed in normal CD34+ hematopoietic stem and progenitor cells. From microarray datasets, aberrant expression of ZNF521 has been reported in both pediatric and adult acute myeloid leukemia (AML) patients with MLL gene rearrangements. However, a proper validation of microarray data is lacking, likewise ZNF521 contribution in MLL-rearranged AML is still uncertain. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE79110

ID:: 200079110

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005325911.

Retinoid induced differentiation of NB4 APL leukemic cells

(Submitter supplied) We report the use of RNAseq to determine genomewide transcriptional changes induced by all-trans retinoic acid differentiation of NB4 acute promyelocytic leukemia (APL) cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
4 Samples

Download data: TXT

Series

Accession:: GSE53259

ID:: 200053259

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005325812.

The role of TFEB in retinoid induced differentiation of NB4 APL leukemic cells (shTFEB)

(Submitter supplied) We report the use of RNAseq to determine the role of the TFEB transcription factor in all-trans retinoic acid induced differentiation of NB4 acute promyelocytic leukemia (APL) cells. We used lentiviral mediated shRNA approaches to functionally deplete TFEB in NB4 cells and compared the transcriptomes of wild type, scramble control shRNA and shTFEB knockdown cells treated with ethanol (control) versus all-trans retinoic acid for 72 hours.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
8 Samples

Download data: TXT

Series

Accession:: GSE53258

ID:: 200053258

Select item 20019396413.

mRNA expression quantitative Analysis of Kasumi-1 treated with I13 compared with control

(Submitter supplied) The goals of this study are toevaluate the mRNA expressions of genes in Kasumi-1 cell lines treated with I13

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: TXT

Series

Accession:: GSE193964

ID:: 200193964

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012543714.

Functional diversity of inhibitors tackling the differentiation arrest of MLL-rearranged leukemia

(Submitter supplied) Purpose: The chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene have been extensively characterized as a potent oncogenic driver on the molecular and mechanistic level in acute lymphoblastic (ALL) and acute myeloid (AML) leukemia. For its oncogenic function the MLL fusion protein is hijacking the the multi enzyme super elongation complex (SEC) leading to elevated expression of MLL target genes (e.g. more...