GEO DataSets

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the intestine of young growing rats after mild restriction of food intake for one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

5 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1355 GPL341

45 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the muscle of young growing rats after mild restriction of food intake for one week or one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the brain of young growing rats after mild restriction of food intake for one week or one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the adipose tissue of young growing rats after mild restriction of food intake for one week or one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

20 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the liver of young growing rats after mild restriction of food intake for one week or one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

20 Samples

Download data: CEL

(Submitter supplied) Background: Calorie restriction (CR) is the only intervention known to extend lifespan in a wide range of organisms, including mammals. However, the mechanisms by which it regulates mammalian aging remain largely unknown and the involvement of the TOR and Sirtuin pathways (which regulate aging in lower organisms) remain controversial. Femaleness is a second phenotype generally associated with longevity but the relationship between sex-biased and CR-induced gene expression remains undetermined. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6761

23 Samples

Download data: GPR

(Submitter supplied) Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230 arrays and validated by qRT-PCR on 18 genes. In heart, age- associated changes but not CR-associated changes in old. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3102

Platform:

GPL1355

39 Samples

Download data: CEL

Analysis of hearts and white adipose tissues of 28 month old male animals fed a calorie restricted diet since 4 months of age. Sustained caloric restriction (CR) extends lifespan in animal models. Results provide insight into the molecular basis of CR-induced lifespan extension.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 age, 2 growth protocol, 2 tissue sets

Platform:

GPL1355

Series:

GSE6718

39 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

448 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of a short-term calorie restricted diet was evaluated in epididymal white adipose tissue (WAT) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

112 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of a short-term calorie restricted diet was evaluated in heart in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

112 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of a short-term calorie restricted diet was evaluated in gastrocnemius muscle (GASTROC) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

112 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of a short-term calorie restricted diet was evaluated in cerebral cortex in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

112 Samples

Download data: CEL, CHP

(Submitter supplied) Diminishment of colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an efficient strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here we report the effects of lifelong CR on markers of colonic health in aging mice. We show that 30% energy reduction, as compared to a control (C) and moderate-fat (MF) diet, is associated with attenuated immune-related gene expression and lower levels of bile acids in the colon. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11533

42 Samples

Download data: CEL

(Submitter supplied) Sarcopenia is an age-associated loss of skeletal muscle mass and strength that increases the risk of disability. Calorie restriction (CR), the consumption of fewer calories while maintaining adequate nutrition, mitigates sarcopenia and many other age-related diseases. To identify potential mechanisms by which CR preserves skeletal muscle integrity during aging, we used mRNA-Seq for deep characterization of gene regulation and mRNA abundance in skeletal muscle of old mice compared with old mice subjected to CR. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9250

2 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) This study explored the role of the growth hormone (GH) / insulin-like growth factor 1 (IGF-1) axis on the life-long caloric restriction (CR)-associated remodeling of white adipose tissue (WAT). Adipocyte size and gene expression profiles, using high-density oligonucleotide microarrays, were analyzed in WAT of six- to seven-month old wild Wistar rats fed ad libitum (AL) or subjected to a 30% caloric restriction (CR), and heterozygous transgenic dwarf rats bearing an anti-sense GH transgene fed ad libitum (Tg). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, TXT

(Submitter supplied) Residual feed intake (RFI) is a measure of feed efficiency, where low RFI denotes high feed efficiency. Caloric restriction (CR) is associated with feed efficiency in livestock species and to human health benefits such as longevity and cancer prevention. We have developed pig lines that differ in RFI and are interested to identify the genes and pathways that underlie feed efficiency. Prepubertal Yorkshire gilts with low RFI (n=10) or high RFI (n=10) were fed ad libitum or at 80% of maintenance for eight days. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

40 Samples

Download data: CEL, CHP

(Submitter supplied) To provide a robust understanding of a transcriptomic change by short-term CR at body fat of mice, we applied three serial strengths of CR to mice including 15%, 30%, and 45% reduction of carbon source. Using Affymetrix mouse 1.0 ST array platform, we obtained and analyzed the transcriptome data for significantly changed genes in expression. Here, we identified 446 genes and categorized the genes based on their biological roles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) AGEMAP is an initiative of the National Institute on Aging (NIA) designed to study the aging process on mice with Caloric Restriction (CR) versus Ad Libitum (AL) diet. The aim of the AGEMAP project is to provide a valuable source of information about genetic influences involved in aging of the major organ systems. A total of 67 mice (C57BL/6) were sacrificed. Both male and female mice were divided in 7 categories based on the diet and the age. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL4358 GPL2552

28 Samples

Download data: TIFF, TXT