GEO DataSets

(Submitter supplied) Directing both organismal homeostasis and physiological adaptation, the pituitary is a key endocrine gland in all vertebrates. It communicates the needs of the organism to different organs by secreting hormones into the bloodstream. Here, we have used the model fish medaka (Oryzias latipes) to investigate the developmental dynamics in the pituitary using a comprehensive RNA-seq time series from 31 to 375 days post-fertilization.

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27992

84 Samples

Download data: XLSX

(Submitter supplied) The pituitary is the vertebrate endocrine gland responsible for the production and secretion of several essential peptide hormones. These, in turn, control many aspects of an animal’s physiology and development, including growth, reproduction, homeostasis, metabolism and stress responses. In teleost fish, each hormone is presumably produced by a specific cell type. However, key details on the regulation of, and communication between these cell types are still poorly understood. more...

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23039

2 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) The anterior pituitary gland drives a set of highly conserved physiologic processes in mammalian species. These hormonally controlled processes are central to somatic growth, pubertal transformation, fertility, lactation, and metabolism. Current models, largely based on candidate gene based immuno-histochemical and mRNA analyses, suggest that each of the seven hormones synthesized by the pituitary is produced by a specific and exclusive cell-lineage. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

10 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) Transcription factors and signaling pathways that regulate stem cells and specialized hormone-producing cells in the pituitary gland have been the subject of intense study and have yielded a mechanistic understanding of pituitary organogenesis and disease. Yet, the regulation of stem cell proliferation and differentiation, the heterogeneity among specialized hormone-producing cells, and the role of non-endocrine cells in the gland remain important, unanswered questions. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

2 Samples

Download data: CSV, MTX, TSV

(Submitter supplied) Several processes governing growth and metabolism are regulated by the neuroendocrine system, particularly the trophic hormones produced in the anterior pituitary gland. However, many of the differences that exist in pituitary gene expression and functional gene networks associated with divergent growth characteristics are still largely unknown. Using the Del-Mar 14K Chicken Integrated Systems microarray, this experiment evaluated global gene expression in the anterior pituitary gland during the first 7 weeks of post-hatch growth in two lines of chickens genetically selected for high growth (HG) or low growth (LG) at SRA-INRA, France. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL1731

31 Samples

Download data: TXT

(Submitter supplied) The goal of the study was to understand how integrin beta1 expressed in epithelial cells directs developmental angiogenesis. Integrin beta1 was deleted specifically in the pituitary glands of embryonic mice. RNA was isolated from knockout and WT control pituitaries dissected at e12.5, one day prior to the initiation of developmental angiogenesis.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

5 Samples

Download data: TXT

(Submitter supplied) Chromatin accessibility of nine embryonic samples was profiled using transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) to identify potential regulatory elements.

Organism:

Oryzias latipes

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL25587

18 Samples

Download data: BED, BW

(Submitter supplied) We collected ten embryonic stages covering cleavage, blastula, gastrula, somite, and late stages until hatching. We also collected two adult tissue samples, including ovary and testis. 13 samples were sequenced using the illumina short-read sequencing platform.

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17089 GPL25587

24 Samples

Download data: FA, GFF3, TAB, TXT

(Submitter supplied) From mammals to fish, gametogenesis and sexual maturation are driven by luteinizing hormone (LH) and follicle-stimulating hormone (FSH), the gonadotropic hormones temporally secreted from the pituitary. Teleost fish are an excellent model for addressing the unique regulation and function of each gonadotropin cell because, unlike mammals, they synthesize and secrete LH and FSH from distinct cells. Only two very distant vertebrate classes (fish and birds), demonstrate the mono-hormonal strategy suggesting a potential convergent evolution. more...

Organism:

Oreochromis niloticus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23067

24 Samples

Download data: TXT

(Submitter supplied) This study aimed at providing insights into the hypothesized functional link between olfactory sensing of the spawning ground and final sexual maturation. We have therefore assessed the presence and expression levels of olfactory genes by RNA sequencing (RNAseq) of the olfactory rosettes in homing chum salmon Oncorhynchus keta Walbaum from the coastal sea to 75 km upstream the rivers at the pre-spawning ground. more...

Organism:

Oncorhynchus keta

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20852

12 Samples

Download data: FA, XLSX

(Submitter supplied) medaka testies transcriptome were sequenced using RNA-seq

Organism:

Oryzias latipes

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23308

27 Samples

Download data: FPKM_TRACKING

(Submitter supplied) It is often the case that inadequate numbers of biological replicates are utilized in differential gene expression analysis. We describe an easy and effective RNA-seq approach using molecular barcoding to enable profiling a large number of replicates simultaneously. This approach significantly improved the performance of differential gene expression analysis. Using this approach in medaka fish (Oryzias latipes), we discovered novel genes with sexually dimorphic expression, and genes necessary for germ cell development. more...

Organism:

Mus musculus; Oryzias latipes; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL25587 GPL26363

12 Samples

Download data: TSV