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Links from GEO DataSets

Items: 6

1.

Human placental exosomes induce maternal systemic immune tolerance in a monocyte-dependent manner

(Submitter supplied) Maternal immune tolerance toward to the semi-allograft fetus is a prerequisite condition for successful pregnancy. However, the role of maternal monocytes in the induction of systemic immune tolerance is poorly understood. Here we report that placenta facilitates maternal immune tolerance by extruding exosomes. Maternal monocytes were transformed into an immunosuppressive phenotype after taking up exosomes. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30209
8 Samples
Download data: TXT
Series
Accession:
GSE184020
ID:
200184020
2.

Placental exosomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL30209 GPL11154
12 Samples
Download data
Series
Accession:
GSE184195
ID:
200184195
3.

Placental exosomes polarize human monocyte-derived macrophages to a decidual M2-like macrophage phenotype

(Submitter supplied) Macrophages are abundant in uterine mucosa during the peri-implantation phase and early pregnancy. Decidual macrophages display dynamic changes alone with pregnancy progress: During the peri-implantation phase, macrophages displayed a pro-inflammatory phenotype which facilitates embryo implantation. While, In the late firster trimester and second trimester, decidual macrophages are anti-proinflammatory which are helpful to pregnancy maintenance. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
4 Samples
Download data: TXT
Series
Accession:
GSE184194
ID:
200184194
4.

Human exosomal placenta-specific miRNAs modulate expression of target genes in maternal immune cells during pregnancy

(Submitter supplied) We investigated placenta-specific miRNA miR-517a (miR-517a-3p) functions in Jurkat cells. For this purpose, we identified candidate target mRNAs of the placenta-specific miRNAs using DNA microarray analysis. Transfection of Jurkat cells with miR-517a significantly downregulated 123 genes. Among the 123 genes identified, we searched for potential direct targets of miR-517a using the online software MicroCosm Targets. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
2 Samples
Download data: TXT
Series
Accession:
GSE50814
ID:
200050814
5.

Small RNA sequencing of cow's peripheral plasma exosomes

(Submitter supplied) OBJECTIVE: To reveal the miRNA expression profile of placental exosomes by high-throughput sequencing and screen key biomarkers in different pregnancy period to provide new research ideas for the establishment and maintenance of pregnancy in cows and other ruminants.It can also provide reference for other pregnancy diseases. METHOD: Exosmal miRNAs were isolated from non-pregnant cows(n=3,Gestation Day(G.D.) 0),early pregnant cows(n=3,G.D.60),Middile pregnant cows(n=3,G.D.150),Late pregnant cows(n=3,G.D.240), small RNA profiles were generated by deep sequencing, in triplicate, using Illumina Hiseq SE50. more...
Organism:
Bos taurus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL19172
12 Samples
Download data: TXT
Series
Accession:
GSE110324
ID:
200110324
6.

Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth

(Submitter supplied) Purpose: Identify differences in gene expression profiles in fetal monocytes - cells that persist and differentiate postnatally - according to distinct placental histologic domains. Methods: We first isolated classical and intermediate monocyte subsets via FACS and performed transcriptomic profiling of 140 samples (70 classical and 70 intermediate monocyte samples) using bulk RNA-Seq. Results: We report that placental lesions are associated with gene expression changes in fetal monocyte subsets. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
171 Samples
Download data: CSV, TXT
Series
Accession:
GSE195727
ID:
200195727
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