Similar studies for GEO DataSets (Select 200205085) - GEO DataSets

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Items: 2

Select item 2002050851.

Loss of Glo2 alters the glucose metabolism in zebrafish

(Submitter supplied) Glyoxalase 2 is the second enzyme of the glyoxalase system, catalyzing the detoxification of methylglyoxal to D-lactate via SD-Lactoylglutathione. Recent studies have suggested Glo2 as a regulator of glycolysis, but the physiological functions of Glo2 in vivo and organ specific functions of the enzyme have not yet been evaluated. Therefore, a CRISPR/Cas9 knockout of glo2 in zebrafish was created and analyzed. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24776
12 Samples

Download data: TXT

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Accession:: GSE205085

ID:: 200205085

PubMed Full text in PMC Similar studies

Select item 2001687862.

Next Generation Sequencing Facilitates Quantitative Analysis of Wildtype, akr1a1a-/- and Wildtype with Acrolein Treatment Zebrafish Larvae Transcriptomes

(Submitter supplied) Our previous experiments showed the function of Akr1a1a was related to insulin resistance. The knockout of Akr1a1a led to poor acrolein detoxification and accumulated acrolein inhibits insulin receptors (insra/insrb) expression. To understand how the loss of Akr1a1a and acrolein reflects at the transcriptome level, we performed full genome RNA-Seq between akr1a1a+/+, akr1a1a-/- and akr1a1a+/+ with acrolein treatment zebrafish larvae at 120 hpf. more...