GEO DataSets

(Submitter supplied) Strategies that promote functional organ growth with minimal adverse effects are the ultimate goal of regenerative medicine but no single approach is currently available for organ level repair. Here, using an evolutionary adapted in vivo infection model - Mycobacterium leprae, with host cell reprogramming ability and its natural animal host, the nine-banded armadillo (Dasypus novemcinctus) that harbor bacteria in the highly regenerative liver - we present an in vivo model for promoting adult liver growth at organ level without adverse effects. more...

Organism:

Dasypus novemcinctus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL32766

12 Samples

Download data: TSV

(Submitter supplied) Mammalian tissues have a limited regenerative capacity. Previous studies showed that dedifferentiation contributes to tissue regeneration in non-mammalian vertebrate species such as zebrafish and newt. However, dedifferentiation is rarely observed in mammalian tissues even in the neonatal stage and therefore artificial induction of dedifferentiation might enhance regeneration in mammalian tissues. Here we demonstrate that short-term expression of Yamanaka 4 factors (4F) induces dedifferentiation and proliferation in the liver by using lineage-traceable, hepatocyte-specific 4F inducible mouse model. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL13112 GPL19057 GPL21103

29 Samples

Download data: H5, TXT, XLSX

(Submitter supplied) Currently, much effort is directed to the development of new cell sources for clinical therapy using cell fate conversion approaches by small molecules. Direct lineage reprogramming to a progenitor state has been reported in terminally differentiated rodent hepatocytes, yet remains a challenge in human hepatocytes. Human hepatocytes were isolated from healthy and diseased donor livers and reprogrammed into progenitor cells by two small molecules, A83-01 and CHIR99021 (AC), in the presence of EGF and HGF. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

7 Samples

Download data: TXT