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Links from GEO DataSets

Items: 11

1.
Full record GDS2094

Pregnane X receptor agonist effect on the liver (RAE230B)

Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL342
Series:
GSE4959
9 Samples
Download data
2.

Expression data from adult Rattus liver

(Submitter supplied) Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS2093 GDS2094
Platforms:
GPL341 GPL342
19 Samples
Download data
Series
Accession:
GSE4959
ID:
200004959
3.
Full record GDS2093

Pregnane X receptor agonist effect on the liver (RAE230A)

Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL341
Series:
GSE4959
10 Samples
Download data
4.

RNA-Seq Profiling of Pharmacological Activation of PXR and CAR Mice

(Submitter supplied) This study aimed to quantify and compare the mRNA abundance of major xenobiotic processing genes in liver following activation of PXR and CAR using RNA-Seq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
9 Samples
Download data: ZIP
Series
Accession:
GSE104734
ID:
200104734
5.

Hepatic transcriptome of rats treated with vehicle or fipronil (3 mg/kg/d per os for 14 days)

(Submitter supplied) Fipronil (CAS #: 120068-37-3), a widely used insecticide, has been described as a thyroid disruptor in rat inducing a marked increase in thyroxine (T4) clearance resulting in a decrease in T4 plasma concentration. These effects seem to require the bioactivation of fipronil via its biotransformation into fipronil sulfone by cytochromes P450 (CYP). Here, we hypothesized that fipronil-induced thyroid disruption may, at least in part, result from the induction of hepatic enzymes involved in the metabolism of thyroid hormones. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
15 Samples
Download data: TXT
Series
Accession:
GSE39378
ID:
200039378
6.

Gene expression analysis in rat liver after exposure to pregnenolone-16α-carbonitrile

(Submitter supplied) RCCHanTM:WIST male rats were administered for 7 days by oral gavage with vehicle (corn oil) or 100 mg/kg/day of pregnenolone-16α-carbonitrile(PCN). We used microarrays to evaluate gene expression profiling in rat liver at the early phase of treatment with PCN.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL14797
6 Samples
Download data: TXT
Series
Accession:
GSE95475
ID:
200095475
7.

The effect of PCN on gene expression in mouse primary hepatocytes

(Submitter supplied) The effect of prototypical pregnane receptor X (PXR) agonist (pregnenolone 16α-carbonitrile) PCN on hepatic gene expression was studied in mice primary hepatocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL9746
2 Samples
Download data: CEL
Series
Accession:
GSE106293
ID:
200106293
8.

The effect pregnane receptor X (PXR) agonist PCN on hepatic gene expression in mouse liver with and without glucose

(Submitter supplied) The mice were treated i.p. with pregnenolone-16-α-carbonitrile (PCN, 50mg/kg dissolved in DMSO-corn oil 1:3) or vehicle (DMSO-corn oil 1:3) once daily for four days. The mice were fasted for four hours and then administered glucose (2g/kg) by oral gavage or further kept on fasting. The mice were sacrificed 1 hour after glucose administration.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21278
12 Samples
Download data: TXT
Series
Accession:
GSE125695
ID:
200125695
9.

Triazole Antifungal Toxicogenomics: rat_repro_Testis

(Submitter supplied) The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was conducted on liver and testis from Wistar Han IGS rats fed myclobutanil (M: 500, 2000 ppm), propiconazole (P: 500, 2500 ppm), or triadimefon (T: 500, 1800 ppm) from gestation day six to postnatal day 92. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
34 Samples
Download data: CEL
Series
Accession:
GSE10412
ID:
200010412
10.

Triazole Antifungal Toxicogenomics: rat_repro_Liver

(Submitter supplied) The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was conducted on liver and testis from Wistar Han IGS rats fed myclobutanil (M: 500, 2000 ppm), propiconazole (P: 500, 2500 ppm), or triadimefon (T: 500, 1800 ppm) from gestation day six to postnatal day 92. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
35 Samples
Download data: CEL
Series
Accession:
GSE10411
ID:
200010411
11.

A Novel Statistical Algorithm for Gene Expression Analysis Differentiates PXR-Dependent and Independent Mechanisms of Toxicity

(Submitter supplied) The objective of the present study is to examine the potential role of the pregnane x receptor (PXR) in mice treated with an small molecule inhibitor for beta-secretase (CMP013)
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
20 Samples
Download data: CEL
Series
Accession:
GSE23780
ID:
200023780
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