GEO DataSets

Analysis of CD34+ cells from 55 patients with myelodysplastic syndromes (MDSs). MDSs are a heterogeneous group of hematopoietic malignancies, characterized by blood cytopenias, ineffective hematopoiesis, and a hypercellular bone marrow. Results provide insight into the pathophysiology of MDS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 disease state sets

Platform:

GPL570

Series:

GSE4619

66 Samples

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(Submitter supplied) In order to gain insight into the poorly understood pathophysiology of the myelodysplastic syndromes (MDS), we have determined the gene expression profiles of the CD34+ cells of 55 MDS patients using the Affymetrix GeneChip U133 Plus2.0 platform Keywords: Disease v normal

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2118

Platform:

GPL570

66 Samples

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(Submitter supplied) Microarray analysis with 40,000 cDNA gene chip arrays determined differential gene expression profiles (GEPs) in CD34+ marrow cells from myelodysplastic syndrome (MDS) patients compared to normal individuals. Using focused bioinformatics analyses, we found 1175 genes significantly differentially expressed by MDS vs Normal, requiring a minimum of 39 genes to separately classify these patients. Major GEP differences were demonstrated between Normal and MDS patients and between several MDS subgroups: (1) those whose disease remained stable (sMDS) and those who subsequently transformed (tMDS) to acute myeloid leukemia (AML); (2) between del(5q) and other MDS patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9335

41 Samples

Download data: TXT

(Submitter supplied) Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcriptional activity in the human genome. Noncoding-RNAs (ncRNAs) transcribed from intronic regions of genes are involved in a number of processes related to post-transcriptional control of gene expression, and in the regulation of exon-skipping and intron retention. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9193

15 Samples

Download data: TXT

(Submitter supplied) A 10K cDNA microarray was used to compare neutrophil RNA from 21 MDS patient and 2 AML patients to pooled neutrophil RNA from 7 healthy controls. Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL334

45 Samples

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(Submitter supplied) Early, low risk IPSS (International Prognostic Scoring System) myelodysplasia (MDS) is a heterogeneous disorder where the molecular and cellular haematopoietic defects are poorly understood. To gain insight into this condition, we analyzed gene expression profiles of marrow CD34+ progenitor cells from normal karyotype, low blast count MDS patients, age-matched controls and patients with non-MDS anaemia. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1392

Platform:

GPL96

28 Samples

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Analysis of bone marrow CD34+ progenitor cells from normal-karyotype, low-blast-count, early, low-risk myelodysplastic syndrome (MDS) patients, age-matched controls, and patients with non-MDS anemia. Results provide insight into pathogenesis of MDS and identify putative markers of MDS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 disease state sets

Platform:

GPL96

Series:

GSE2779

28 Samples

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(Submitter supplied) Epigenetic mechanisms contribute to deregulated gene expression of hematopoietic progenitors in Myelodysplastic Syndromes (MDS). Hypomethylating agents are able to improve peripheral cytopenias in MDS patients. To identify critical gene expression changes induced by hypomethylating agents, we analyzed gene expression profiling (GEP) of myelodysplastic and normal CD34+ hematopoietic stem cells treated in vitro with or without decitabine. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

30 Samples

Download data: CEL

(Submitter supplied) In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregulated pathways in MDS include interferon signaling, thrombopoietin signaling and the Wnt pathway. Among the most significantly deregulated gene pathways in early MDS are immunodeficiency, apoptosis and chemokine signaling, whereas advanced MDS is characterized by deregulation of DNA damage response and checkpoint pathways. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3795

Platform:

GPL570

200 Samples

Download data: CEL

Analysis of bone marrow CD34+ hematopoietic stem cells of myelodysplastic syndrome (MDS) patients. MDS is a group of clonal hematopoietic stem cell malignancies characterized by ineffective hematopoiesis. Results provide insight into the molecular pathogenesis of MDS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 5 specimen sets

Platform:

GPL570

Series:

GSE19429

200 Samples

Download data: CEL

(Submitter supplied) Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal stem cell disorders. We hypothesize that gene expression changes in the bone marrow (BM) microenvironment might play a fundamental role in the development and progression of MDS. The goal of the present study is to investigate the differences in gene expression profiles of BM mesenchymal stromal cells (MSCs) between MDS patients and normal individuals, as well as between MDS subtypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5622

Platform:

GPL10558

14 Samples

Download data: TXT

Analysis of bone marrow (BM) mesenchymal stromal cells from adult patients representing MDS subtypes RCMD (refractory cytopenia with multilineage dysplasia) and RAEB (refractory anemia with excess blasts). Results provide insight into molecular changes in the BM microenvironment contributing to MDS.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 disease state sets

Platform:

GPL10558

Series:

GSE61853

14 Samples

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