GEO DataSets

Analysis of female C57BL/6 lungs at various time points after influenza A virus or Streptococcus pneumoniae infection. Secondary bacterial infection during or after influenza recovery is common cause of pneumonia (PN). Results provide insight into molecular pathogenesis of severe infectious PN.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 infection, 5 time sets

Platform:

GPL1868

Series:

GSE5289

7 Samples

Download data

(Submitter supplied) Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated by immune receptors specifically recognizing pathogenic structures serving to elicit a qualitatively and quantitatively adequate immune response. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2165

Platform:

GPL1868

7 Samples

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(Submitter supplied) This microarray experiment is part of a study addressing the importance of glutamine metabolism in Streptococcus pneumoniae for the virulence of this bacterium. To be able to gain more insight into the phenotype of a double mutant of glnA (TIGR 4 locus tag SP0502, encoding glutamine synthetase) and glnP (SP1241, encoding a permease component of a glutmine uptake ABC transporter), the transcriptome of this mutant, the glnPA double mutant, was determined in strain S. more...

Organism:

Streptococcus pneumoniae

Type:

Expression profiling by array

Platform:

GPL6268

4 Samples

Download data: TXT

(Submitter supplied) To understand the host transcriptional response to S. enterica serovar Choleraesuis (S. Choleraesuis), the first generation Affymetrix porcine GeneChip® was used to identify differentially expressed genes in the mesenteric lymph nodes responding to infection at acute (8 hours (h), 24h, 48h post-inoculation (pi)) and chronic stages (21 days (d) pi) The objectives of this study were to identify and examine the stereotypical gene expression response within the host mesenteric lymph nodes to S. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

15 Samples

Download data: CEL, EXP

(Submitter supplied) In the field, adult male rodents are more frequently infected with hantaviruses than females. Early data suggests that sex steroid hormones modulate sex differences in host immune response. This project focuses on elucidating sex differences in gene expression in the lungs of infected males 15 and 40 days post infection with Seoul virus (naturally occurring hantavirus in Norway rats) relative to infected females 15 and 40 days post infection on 12 RG_U34 GeneChips. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS62

Platform:

GPL85

12 Samples

Download data: CEL

Gene expression in lungs of males 15 and 40 days post-infection with Seoul hantavirus compared with females. Part of an investigation into whether sex steroid hormones modulate sex differences in host immune response.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 gender, 3 infection sets

Platform:

GPL85

Series:

GSE488

12 Samples

Download data: CEL

(Submitter supplied) The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suitable to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilizing a dual RNAseq approach that allowed us to investigate both viral and host gene expression in the same individual from a single expression assay after H1N1 infection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16790

36 Samples

Download data: TXT

(Submitter supplied) Streptococcus (S.) pneumoniae is the most frequently isolated causative pathogen community-acquired pneumonia, a leading cause of mortality worldwide. We investigated the role of the inflammasome sensor NLRP3 and the inflammasome adapter ASC during S. pneumoniae pneumonia. Detailed analysis of the early inflammatory response in the lung by whole genome transcriptional profiling, we identified several mediators that were differentially expressed between Nlrp3-/- and Asc-/ - mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

64 Samples

Download data: TXT

(Submitter supplied) Bladders examined at 1, 4 and 24 hours after lipopolysaccharide, substance P or ovalbumin challenge. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL144

12 Samples

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(Submitter supplied) Seasonal and pandemic influenza is a cause of morbidity and mortality worldwide. Most people infected with influenza virus display mild to moderate disease phenotypes and recover within a few weeks. Influenza is known to cause persistent alveolitis in animal models, however little is known about the molecular pathways involved in this phenotype. We challenged C57BL/6 mice with influenza A/PR/8/34 and examined lung pathology and inflammation, as well as transcriptomic and epigenetic changes at 21 to 60 days post-infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

32 Samples

Download data: TXT

(Submitter supplied) To study the effects of secondary bacterial infection during 1918 pandemic H1N1 influenza virus infection, BALB/c mice were inoculated with the fully reconstructed 1918 influenza virus followed by inoculation with pneumococcus 72h later.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

34 Samples

Download data: TXT

(Submitter supplied) Array analysis of total lung RNA obtained from mice 12,16,24 h post infection with influenza. Strains used were Mock, PR8, X31, VN62 (1x10^5pfu)

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

30 Samples

Download data: TXT

(Submitter supplied) Lung resident memory B cells (BRM cells) are elicited after influenza infections of mice, but connections to other pathogens and hosts have yet to be determined, as has their functional significance. We postulate that BRM cells are core components of lung immunity. To test this, we examined whether lung BRM cells are elicited by the respiratory pathogen pneumococcus, are present in humans, and are important in pneumonia defense. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

20 Samples

Download data: TXT

(Submitter supplied) We used microarray to characterize interferon stimulated genes in dendritic cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL

(Submitter supplied) We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression profiles to protein-coding genes of known function. To build a large panel of diverse host responses to viral infection, we took advantage of the genetic diversity present in the 8 founder strains of the Collaborative Cross (CC) mouse resource. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL11002

123 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

132 Samples

Download data: CEL

(Submitter supplied) Endogenous circadian rhythms regulate the hosts response to influenza infection, more through the host tolerance pathways rater than direct effects on anti-viral resistance.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

25 Samples

Download data: TXT

(Submitter supplied) Deep sequencing of cDNA from Streptococcus pneumoniae EF3030 bacteria and normalized human broncial epithelial cells (nHBEC), alone, together, and after coincubation with Influenza A virus pH1N1.

Organism:

Influenza A virus; Streptococcus pneumoniae; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

14 Samples

Download data: MATRIX

(Submitter supplied) In this study, we performed a cross-species gene expression study of the peripheral blood from the Collaborative Cross (CC) mouse population after Influenza virus (IV).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11202

127 Samples

Download data: TXT

(Submitter supplied) When challenged with an invading pathogen, host defense mechanisms are engaged to eliminate the pathogen (resistance) and limit tissue damage that results from host-pathogen interactions (disease tolerance). We identified Arhgdia as a driver of the molecular disease-tolerance response in epithelial cells. The effect of Arhgdia on disease tolerance and resistance was evaluated at early stages of influenza A virus (IAV) infection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

12 Samples

Download data: CSV