GEO DataSets

Analysis of septic neutrophils treated with lipopolysaccharide or high mobility group box 1 (HMGB1) protein. Neutrophils isolated from patients with sepsis-induced acute lung injury (ALI). HMGB1 is a late mediator of endotoxin lethality, and neutrophils play a role in endotoxemia-associated ALI.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 8 individual sets

Platform:

GPL96

Series:

GSE3037

24 Samples

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(Submitter supplied) Peripheral blood neutrophils were isolated from septic patients and treated in vitro with LPS or HMGB1 Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2214

Platform:

GPL96

24 Samples

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(Submitter supplied) Neutrophil gene transcription following lipopolysaccharide exposure. Microarray analysis of lipopolysaccharide-treated human neutrophils. Neutrophils respond to infection by degranulation, release of reactive oxygen intermediates, and secretion of chemokines and cytokines; however, activation of neutrophil transcriptional machinery has been little appreciated. Recent findings suggest that gene expression may represent an additional neutrophil function after exposure to lipopolysaccharide (LPS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL222

6 Samples

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(Submitter supplied) Rationale: The acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease’s complex pathophysiology, yet these cells have been little studied. Objectives: To examine the functional and transcriptional profiles of patient blood and alveolar neutrophils compared to healthy volunteer cells, and define their sensitivity to phosphoinositide 3-kinase inhibition. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

94 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

225 Samples

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(Submitter supplied) The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on a global scale. However, while the use of genome-wide profiling technologies has become widespread, measuring the plasma proteome still presents considerable challenges. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

49 Samples

Download data: TXT

(Submitter supplied) The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on a global scale. However, while the use of genome-wide profiling technologies has become widespread, measuring the plasma proteome still presents considerable challenges. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: TXT

(Submitter supplied) The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on a global scale. However, while the use of genome-wide profiling technologies has become widespread, measuring the plasma proteome still presents considerable challenges. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: TXT

(Submitter supplied) The wide array of molecules carried by plasma regulates critical immune functions and constitutes valuable biomarkers and therapeutic targets. In recent years the introduction of “systems approaches” has provided investigators with powerful means for assessing immune responses in patient samples on a global scale. However, while the use of genome-wide profiling technologies has become widespread, measuring the plasma proteome still presents considerable challenges. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: TXT

(Submitter supplied) Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A prospective cross-sectional study. Setting: A 20-bed general intensive care unit of a tertiary referral hospital. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3085

Platform:

GPL4274

72 Samples

Download data: GPR

(Submitter supplied) To examine whether gene-expression profiling of circulating leukocytes is different between patients with sepsis as compared to controls. The signature genes identified will then be used to develop a prediction model to assist the diagnosis of sepsis. Keywords: Prediction study

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2808

Platform:

GPL4274

94 Samples

Download data: GPR

Analysis of leukocytes from patients with gram-positive or gram negative sepsis. Results provide insight into the specificity of the host response to gram-positive and gram negative sepsis.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 4 disease state sets

Platform:

GPL4274

Series:

GSE6535

72 Samples

Download data: GPR

Analysis of neutrophils from critically ill patients with sepsis. Results used to define a gene expression signature for sepsis and provides insight into the host response to sepsis.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 disease state, 2 protocol sets

Platform:

GPL4274

Series:

GSE5772

94 Samples

Download data: GPR