GEO DataSets

Analysis of primary testicular diffuse large B cell lymphomas (DLBCLs) and nodal DLBCLs. DLBCLs are classified as germinal center B cell-like (GCB), activated B cell-like, or undetermined. GCB is associated with a favorable prognosis. Results provide insight into the nature of testicular DLBCL.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 disease state, 2 tissue sets

Platform:

GPL3408

Series:

GSE4296

36 Samples

Download data: IMAGENE

(Submitter supplied) Diffuse large B cell lymphomas (DLBCL) constitute a heterogeneous group of lymphomas in which germinal center B cell-like and activated B cell-like subtypes can be discerned based on pathology, clinical presentation and gene expression patterns. Testicular DLBCL form an immune-privileged site-related subgroup of DLBCL with an unfavorable prognosis. We used cDNA microarray analysis, immunohistochemistry for CD10, Bcl6 and MUM1, and somatic hypermutation analysis of the immunoglobulin heavy chain gene rearrangements to determine the subtype of primary testicular DLBCL. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2219

Platform:

GPL3408

36 Samples

Download data: IMAGENE, TXT

(Submitter supplied) Primary diffuse large B cell lymphomas of different immune-privileged sites (IP-DLBCL) share many clinical and biological features, such as a relatively poor prognosis, preferential dissemination to other immune-privileged sites and deletion of the HLA region, which suggests that IP-DLBCL represents a separate entity. To further investigate the nature of IP-DLBCL, we investigated site-specific genomic aberrations in 16 testicular, 9 central nervous system (CNS) and 15 nodal DLBCL using array-CGH. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:

GPL4012 GPL570

80 Samples

Download data: CEL, CHP, GPR

(Submitter supplied) Intrinsic resistance of lymphoma cells to apoptosis is a probable mechanism causing chemotherapy resistance and eventual fatal outcome in patients with diffuse large B cell lymphomas (DLBCL). We investigated whether microarray expression profiling of apoptosis related genes predicts clinical outcome in 46 patients with primary nodal DLBCL. Unsupervised cluster analysis using genes involved in apoptosis (N=246) resulted in 3 separate DLBCL groups partly overlapping with GCB versus ABC like phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3255

54 Samples

Download data

(Submitter supplied) Loss of human leukocyte antigen (HLA) expression on tumor cells is frequent in diffuse large B cell lymphoma (DLBCL) arising in immune-privileged sites such as the testis and central nervous system and is associated with small homozygous deletions of HLA-DQ/DR and larger hemizygous deletions of the major histocompatibility complex (MHC) region. To better understand the significance of downregulation of HLA class II expression in relation to the homozygous and hemizygous deletions, we analyzed global gene expression patterns in a series of 26 testicular diffuse large B-cell lymphomas (DLBCL) after characterization of these deletions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1960

Platform:

GPL3408

36 Samples

Download data: IMAGENE, TXT

Analysis of testicular diffuse large B cell lymphoma (DLBCL) tissues with small homozygous HLA-DQ/HLA-DR deletions, larger hemizygous MHC complex deletions, or without deletions. Results provide insight into the significance of the downregulation of HLA class II expression in testicular DLBCL.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 disease state, 3 other sets

Platform:

GPL3408

Series:

GSE4157

36 Samples

Download data: IMAGENE

(Submitter supplied) Burkitt Lymphoma patient samples using gene expression to create a molecular definition of the disease. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Keywords: clinical history design

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3706

303 Samples

Download data

(Submitter supplied) We obtained gene expression data and HD-SNP6.0 copy number data from PTL, PCNSL and PMLBCL samples and performed an integrative analysis on them. RNA was whole genome amplified using Nugen.

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by SNP array

Platforms:

GPL6801 GPL96 GPL570

260 Samples

Download data: CEL, TXT