GEO DataSets

Analysis of various tissues from animals bearing maternal or paternal uniparental duplications (UpDps) of chromosome 7 regions. Translocation used to produce UpDps proximal and distal to the breakpoint. Results provide insight into the extent and distribution of imprinted genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation, 5 tissue sets

Platform:

GPL81

Series:

GSE4870

13 Samples

Download data: CEL, EXP

(Submitter supplied) Tissue-specific comparison of gene expression levels in T65H translocation mice, either with or without uniparental duplications of Chrs 7 & 11. Identification of highly differentially expressed transcripts. Keywords: genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2281 GDS2282 GDS2283 GDS2284 GDS2285

5 related Platforms

45 Samples

Download data: CEL, EXP

Analysis of various tissues from animals bearing maternal or paternal uniparental duplications (UpDps) of chromosome 7 regions. Translocation used to produce UpDps proximal and distal to the breakpoint. Results provide insight into the extent and distribution of imprinted genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation, 4 tissue sets

Platform:

GPL83

Series:

GSE4870

11 Samples

Download data: CEL, EXP

Analysis of various tissues from animals bearing maternal or paternal uniparental duplications (UpDps) of chromosome 7 regions. Translocation used to produce UpDps proximal and distal to the breakpoint. Results provide insight into the extent and distribution of imprinted genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 genotype/variation, 5 tissue sets

Platform:

GPL82

Series:

GSE4870

13 Samples

Download data: CEL, EXP

Analysis of embryos and brains of newborns with maternal or paternal uniparental duplications (UpDps) of chromosome 7 regions. Translocation used to produce UpDps. Results provide insight into the extent and distribution of imprinted genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL339

Series:

GSE4870

4 Samples

Download data: CEL, EXP

Analysis of embryos and brains of newborns with maternal or paternal uniparental duplications (UpDps) of chromosome 7 regions. Translocation used to produce UpDps. Results provide insight into the extent and distribution of imprinted genes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL340

Series:

GSE4870

4 Samples

Download data: CEL, EXP

(Submitter supplied) Analysis of gene expression in mouse E15.5 embryonic heart tissue, either wildtype, Ddc-/+ (maternal transmission of Ddc^Gt(OST129277)Lex knockout allele), Ddc+/- (paternal transmission), or Ddc-/-.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

12 Samples

Download data: IDAT, TXT

(Submitter supplied) While it is understood that the genome is organized into large domains, little is known about cell-type specific interactions at individual loci in mammalian development. Imprinted loci represent a compelling feature of chromatin conformation, illustrating how genes are controlled in local domains to drive parental-specific transcriptional programs important for growth: a clear example being the imprinted Grb10-Ddc locus. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL24247

16 Samples

Download data: TAR

(Submitter supplied) Utilizing reciprocal genome-wide uniparental disomy samples presenting with Beckwith-Wiedemann and Silver-Russell syndrome-like phenotypes, we have analyzed ~0.1% of CpG dinucleotides present in the human genome for imprinted differentially methylated regions (DMRs) using the Illumina Infinium HumanMethylation27 BeadChip microarray. This approach identified 15 imprinted DMRs associated with previously characterized imprinted domains, and confirmed the maternal methylation of the RB1 DMR. more...

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

15 Samples

Download data: TXT

(Submitter supplied) Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Imprinting occurs through differential epigenetic marks on the two parental alleles, with most imprinted loci marked by the presence of differentially methylated regions (DMRs). To identify sites of parental epigenetic bias, here we have profiled DNA methylation patterns in a cohort of 57 individuals with uniparental disomy (UPD) for 19 different chromosomes, defining imprinted DMRs as sites where the maternal and paternal methylation levels diverge significantly from the biparental mean. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

66 Samples

Download data: TXT

(Submitter supplied) Transcriptomic analysis of enriched of neuron population collected from in-vivo mouse brains has been a challenge in the neuroscience field due to its fragility in withstanding harsh condition during isolation and collection process. We established a fluorescent reporter mouse Ddc-hKO1 to facilitate the identification and collection of Ddc-expressing neurons (dopaminergic, serotonergic, cholinergic and adrenergic neurons) by the detection of red fluorescence signals using a FACs. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

4 Samples

Download data: TXT, XLSX

(Submitter supplied) Methylation profiles of chr12-16 were generated by meDIP and array hybridisation in 3 cases with maternal uniparental disomy of chromosome 15, and three cases of paternal uniparental disomy of chromosome 15. Comparison of these profiles reveals differentially methylated (imprinted) regions on chromosome 15.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL10483

12 Samples

Download data: PAIR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Methylation profiling by genome tiling array

26 related Platforms

76 Samples

Download data: TXT

(Submitter supplied) Genomic imprinting describes the expression of a subset of mammalian genes from one parental chromosome. The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. We identified the paternally methylated DMR at human chromosome 2 near the imprinted ZDBF2 gene using a methylated-DNA immunoprecipitation-on-chip (meDIP-on-chip) method applied to DNA from sperm.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL9641

1 Sample

Download data: TXT

(Submitter supplied) Genomic imprinting describes the expression of a subset of mammalian genes from one parental chromosome. The parent-of-origin specific expression of imprinted genes relies on DNA methylation of CpG-dinucleotides at differentially methylated regions (DMRs) during gametogenesis. We identified the paternally methylated DMRs at mouse chromosome 1 near the imprinted Zdbf2 gene using a methylated-DNA immunoprecipitation-on-chip (meDIP-on-chip) method applied to DNA from parthenogenetic (PG)- and androgenetic (AG)-derived cells and sperm. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

25 related Platforms

75 Samples

Download data: TXT

(Submitter supplied) Gene expression profiling was performed on CNS tissue from neonatal mice carrying the T9H translocation and maternal or paternal duplication of proximal Chromosomes 7 and 15. Our analysis revealed the presence of two novel paternally expressed intergenic transcripts at the PWS/AS locus. The transcripts were termed Pec2 and Pec3 for paternally expressed in the CNS.Our analysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

22 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression profiling was performed on CNS tissue from neonatal mice carrying the T9H translocation and maternal or paternal duplication of proximal Chromosomes 7 and 15. Our analysis revealed the presence of two novel paternally expressed intergenic transcripts at the PWS/AS locus. The transcripts were termed Pec2 and Pec3 for paternally expressed in the CNS.Our analysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL340

8 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression profiling was performed on CNS tissue from neonatal mice carrying the T9H translocation and maternal or paternal duplication of proximal Chromosomes 7 and 15. Our analysis revealed the presence of two novel paternally expressed intergenic transcripts at the PWS/AS locus. The transcripts were termed Pec2 and Pec3 for paternally expressed in the CNS.Our analysis also revealed imprinting of Magel2, Mkrn3, Ndn,Ube3a and Usp29, as well as Pec2 and Pec3 in embryonic brain, 15.5 dpc, and provided a survery of biallelically expressed genes on proximal Chromosomes 7 and 15 in embryonic and neonatal CNS. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

14 Samples

Download data: CEL, CHP

(Submitter supplied) In mammalian genomes a subset of genes is regulated by genomic imprinting resulting in silencing of one parental allele. Imprinting is essential for cerebral cortex development but prevalence and functional impact in individual cells is unclear. Here we determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells. We created cells with uniparental disomy (UPD) containing either two copies of the maternal or paternal chromosome hence imprinted genes will be twofold overexpressed or not expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

165 Samples

Download data: TAB, XLSX

(Submitter supplied) In mammalian genomes a subset of genes is regulated by genomic imprinting resulting in silencing of one parental allele. Imprinting is essential for cerebral cortex development but prevalence and functional impact in individual cells is unclear. Here we determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells. We created cells with uniparental disomy (UPD) containing either two copies of the maternal or paternal chromosome hence imprinted genes will be twofold overexpressed or not expressed. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

28 Samples

Download data: TAB