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Links from GEO DataSets

Items: 20

1.
Full record GDS2289

PPARalpha overexpression effect on skeletal muscles

Analysis of skeletal muscles of transgenics (trs) overexpressing PPARalpha. Trs overexpressing PPARalpha develop glucose intolerance despite protection from diet-induced obesity. Results provide insight into the role of PPARalpha in the development of insulin-resistant diabetes.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE5777
4 Samples
Download data
2.

Microarray skeletal muscle PPARbeta overexpressing mice

(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor beta (PPARb) in skeletal muscle of transgenic mice that overexpressed PPARb. The following abstract from the submitted manuscript describes the major findings of this work. The Nuclear Receptor Transcription Factor PPARbeta/delta Programs Muscle Glucose Metabolism. Zhenji Gan, Eileen Burkart-Hartman, Dong-Ho Han, Brian Finck, Teresa C. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE29055
ID:
200029055
3.

Microarray skeletal muscle PPARalpha overexpressing mice

(Submitter supplied) This experiment was conducted to identify target genes of the peroxisome proliferator-activated receptor alpha (PPARa) in skeletal muscle of transgenic mice that overexpressed PPARa. The following abstract from the published manuscript describes the major findings of this work. A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.Finck BN, Bernal-Mizrachi C, Han DH, Coleman T, Sambandam N, LaRiviere LL, Holloszy JO, Semenkovich CF, Kelly DP. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2289
Platform:
GPL339
4 Samples
Download data
Series
Accession:
GSE5777
ID:
200005777
4.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
5.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
6.

Transcriptional profiling reveals divergent roles of PPARa and PPARß/d in regulation of gene expression in mouse liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL7440 GPL6246
34 Samples
Download data: CEL
Series
Accession:
GSE17865
ID:
200017865
7.

mRNA profiling reveals divergent roles of PPARa and PPARß/d in regulating mouse liver gene expression (PPARb/d samples)

(Submitter supplied) Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to better elucidate the function of PPARß/d in liver by comparing the effect of PPARa and PPARß/d deletion using whole genome transcriptional profiling and analysis of plasma and liver metabolites. In fed state, the number of genes altered by PPARa and PPARß/d deletion was similar, whereas in fasted state the effect of PPARa deletion was much more pronounced, consistent with the pattern of gene expression of PPARa and PPARß/d. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE17864
ID:
200017864
8.

PPARalpha Agonists Induce a Fiber-Type Selective Transcriptional Response in Rat Skeletal Muscle

(Submitter supplied) In rodents, treatment with peroxisome proliferator-activated receptor alpha (PPARalpha) agonists results in peroxisome proliferation, hepatocellular hypertrophy and hepatomegaly. Drugs in the fibrate class of PPARalpha agonists have also been reported to produce rare skeletal muscle toxicity. Although target-driven hepatic effects of PPARalpha treatment have been extensively studied, a characterization of the transcriptional effects of this nuclear receptor/transcription factor on skeletal muscle responses has not been reported. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL3631
484 Samples
Download data
Series
Accession:
GSE5100
ID:
200005100
9.

Hindlimb suspension and reloading study

(Submitter supplied) Analysis of effect of hindlimb suspension and reloading on C57Bl/6 mouse soleus muscle. Experimental groups examined: -Control mice, 14 days -Hindlimb suspension for 7 days -Hindlimb suspension for 7 days, and subsequent reloading for 1 day -Hindlimb suspension for 7 days, and subsequent reloading for 7 days Keywords: other
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1097
23 Samples
Download data
Series
Accession:
GSE1293
ID:
200001293
10.

Reloaded 7 days

(Submitter supplied) Hindlimb suspension for 7 days, subsequent reloading for 7 days Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1097
5 Samples
Download data
Series
Accession:
GSE1287
ID:
200001287
11.

Reloaded 1 day

(Submitter supplied) Hindlimb suspended for 7 days, subsequent reloading for 1 day Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1097
6 Samples
Download data
Series
Accession:
GSE1286
ID:
200001286
12.

Hindlimb suspension

(Submitter supplied) Hindlimb suspended for 7 days Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1097
6 Samples
Download data
Series
Accession:
GSE1285
ID:
200001285
13.

Control

(Submitter supplied) Control mice, 14 days Keywords: repeat sample
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1097
6 Samples
Download data
Series
Accession:
GSE1284
ID:
200001284
14.

A high fat diet causes obesity and insulin resistance in mice, but induces small changes in the muscle transcriptome

(Submitter supplied) An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4015
Platform:
GPL7546
30 Samples
Download data: CEL
Series
Accession:
GSE17576
ID:
200017576
15.
Full record GDS4015

High fat diet effect on C57BL/6J quadriceps muscle

Analysis of skeletal muscle of C57BL/6J males fed a high fat diet (HFD) for 8 weeks to induce obesity and insulin resistance. Results provide insight into the molecular mechanisms underlying the development of diet-induced obesity and insulin resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 growth protocol, 2 time sets
Platform:
GPL7546
Series:
GSE17576
30 Samples
Download data: CEL
DataSet
Accession:
GDS4015
ID:
4015
16.

MicroRNA expression profiling of skeletal muscle from PPARalpha- and PPARbeta-overexpressing mice

(Submitter supplied) This experiment was conducted to identify target microRNAs of the peroxisome proliferator-activated receptor (PPAR) in skeletal muscle of transgenic mice that overexpressed PPARalpha or PPARbeta. We have recently demonstrated that skeletal muscle-specific PPARb transgenic (MCK-PPARb) mice exhibit increased exercise endurance, whereas MCK-PPARa mice have reduced exercise performance. Accordingly, we sought to determine whether PPARb and PPARa drive distinct programs involved in muscle fiber type determination. more...
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by RT-PCR
Platforms:
GPL15350 GPL15351
24 Samples
Download data: SDS, TXT
Series
Accession:
GSE36498
ID:
200036498
17.

IMP2 increases mouse skeletal muscle mass and voluntary activity by enhancing autocrine IGF2 production and optimizing muscle metabolism

(Submitter supplied) The Igf2 mRNA binding protein2/Imp2 was selectively deleted from adult mouse muscle; two phenotypes were observed: modestly decreased accrual of skeletal muscle mass after weaning and reduced wheel running activity but normal forced treadmill performance. Reduced voluntary activity occurs when fed a high fat diet but is normalized when consuming standard chow. The reduced muscle mass is due to diminished autocrine Igf2 production, reduced Akt1 activation, disinhibition of Gsk3α and reduced protein synthesis, without altered mTOR complex1 activity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: TXT
Series
Accession:
GSE119801
ID:
200119801
18.

Zinc finger protein overexpression improves glucose homeostasis in mice

(Submitter supplied) Using RNA-Seq, we compared the transcriptomes of muscle from wild type C57BL/6J or Zp407 transgenic mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data: CSV
Series
Accession:
GSE83541
ID:
200083541
19.

Gene expression of wild-type and Ppar-beta null primary keratinocytes, with and without infection with an activated Hras retrovirus, with and without the Ppar-beta specific ligand GW0742

(Submitter supplied) Differential gene expression profiles were observed in response to Hras in either wild-type or Ppar-beta null primary keratinocytes and differentail gene edxpression profiles by GW0742 were only found in wild-type keratinocytes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE32498
ID:
200032498
20.

JNK-mediated control of gene expression in liver

(Submitter supplied) RNAseq analysis of gene expression in Liver of Control and JNK deficient mice fed a control or a High fat diet
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
24 Samples
Download data: TXT
Series
Accession:
GSE55190
ID:
200055190
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