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Links from GEO DataSets

Items: 20

1.
Full record GDS2308

Akt1 serine-threonine protein kinase activation effect on the heart (MG-430B)

Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 protocol sets
Platform:
GPL340
Series:
GSE3383
18 Samples
Download data
DataSet
Accession:
GDS2308
ID:
2308
2.

Analysis of Akt1 activation in transgenic mouse hearts show expression profiles associated with hypertrophy and failure

(Submitter supplied) To investigate molecular mechanisms involved in the development of cardiac hypertrophy and heart failure, a tetracycline-regulated transgenic system to conditionally switch a constitutively-active form of the Akt1 protein kinase on or off in the adult heart was developed. Short-term activation (2 weeks) of Akt1 resulted in completely reversible hypertrophy with maintained contractility. In contrast, chronic Akt1 activation (6 weeks) induced extensive cardiac hypertrophy, severe contractile dysfunction, and massive interstitial fibrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS2304 GDS2308
Platforms:
GPL339 GPL340
36 Samples
Download data
Series
Accession:
GSE3383
ID:
200003383
3.
Full record GDS2304

Akt1 serine-threonine protein kinase activation effect on the heart (MG-430A)

Analysis of hearts after acute or chronic induction of a transgenic Akt1 kinase. Acute activation results in reversible hypertrophy, while chronic activation induces transition to failure. Results provide insight into the mechanisms involved in the development of cardiac hypertrophy and failure.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 5 protocol sets
Platform:
GPL339
Series:
GSE3383
18 Samples
Download data
DataSet
Accession:
GDS2304
ID:
2304
4.

Analysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 2)

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8600
16 Samples
Download data: GPR
Series
Accession:
GSE16246
ID:
200016246
5.

Analysis of cardiac gene expression in response to isoproterenol-induced heart failure (part 1)

(Submitter supplied) Myoglobin knockout mice (myo-/-) adapt to the loss of myoglobin by the activation of a variety of compensatory mechanisms on the structural and functional level. In order to analyze to what extent myo-/- mice would tolerate cardiac stress we used the model of chronic isoproterenol application to induce cardiac hypertrophy in myo-/- mice and wild type (WT) controls. After 14 d of isoproterenol infusion cardiac hypertrophy in WT and myo-/- mice reached a similar level. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8599
16 Samples
Download data: GPR
Series
Accession:
GSE16243
ID:
200016243
6.

Transcriptional profile of isoproterenol-induced cardiomyopathy and comparison to exercise-induced cardiac hypertrophy

(Submitter supplied) We performed microarray analyses on RNA from mice with isoproterenol-induced cardiac hypertrophy and mice with exercise-induced physiological hypertrophy and identified 865 and 2,534 genes that were significantly altered in pathological and physiological cardiac hypertrophy models, respectively.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3596
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE18801
ID:
200018801
7.
Full record GDS3596

Isoproterenol-induced cardiomyopathy and exercise-induced cardiac hypertrophy

Comparison of hearts of C57BL/6 males with isoproterenol-induced cardiomyopathy to those with exercise-induced cardiac hypertrophy. Results provide insight into the molecular differences between pathological and physiological cardiac hypertrophy models.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol sets
Platform:
GPL1261
Series:
GSE18801
9 Samples
Download data: CEL
8.

Gene expression profiles during the development of compensated or decompensated hypertrophy during pressure overload

(Submitter supplied) We recently introduced a modification of the established monocrotaline (MCT) model for pulmonary hypertension (PH) and subsequent right ventricular (RV) hypertrophy, which allows for the selective induction of either a compensate or decompensated RV hypertrophic phenotype within four weeks after a single subcutaneous MCT injection. Both doses of 30 or 80 mg/kg body weight lead to an intermediate phase of compensated RV hypertrophy (day 14-19), while the former dose leads to a stable compensated phenotype (HYP) and the latter dose progresses towards decompensated ventricular hypertrophy and RV failure (CHF) around day 25-28 (Buermans et. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1928
Platform:
GPL1397
27 Samples
Download data: IMAGENE
Series
Accession:
GSE3675
ID:
200003675
9.

Compensated and decompensated hypertrophy after monocrotaline injection

(Submitter supplied) 14 days after a single subcutaneous monocrotaline (MCT) injection we isolated the left and right ventricles from wistar rats. Factor1: Comparison between control (CON), compensated hypertrophy (HYP), and decompensated hypertrophy (CHF). Factor2: Comparison between left ventricle (LV) and right ventricle (RV). Keywords: dose response
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS742
Platform:
GPL1397
24 Samples
Download data
Series
Accession:
GSE1652
ID:
200001652
10.
Full record GDS1928

Compensated and decompensated right ventricular hypertrophy at onset: time course

Temporal analysis of right ventricles at the onset of compensated or decompensated right ventricular hypertrophy. Compensated and decompensated phenotypes induced by injection with 30 and 80 mg/kg monocrotaline, respectively. Results identify potential prognostic markers and therapeutic targets.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, log2 ratio, 3 disease state, 3 time sets
Platform:
GPL1397
Series:
GSE3675
27 Samples
Download data: IMAGENE
DataSet
Accession:
GDS1928
ID:
1928
11.
Full record GDS742

Compensated and decompensated hypertrophies induced by monocrotaline

Analysis of compensated and decompensated hypertrophies induced by monocrotaline in Wistar. Left and right heart ventricles examined 14 days after monocrotaline injection. Decompensated hypertrophy is a prelude to chronic heart failure.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, log ratio, 3 disease state, 2 tissue sets
Platform:
GPL1397
Series:
GSE1652
24 Samples
Download data
DataSet
Accession:
GDS742
ID:
742
12.

Differential expression of genes after 48 hrs, 10 d, and 3 wks of TAC

(Submitter supplied) Microarray analysis of gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 48 hours, 10 days, and 3 weeks. Keywords: time-course
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS794
Platform:
GPL81
26 Samples
Download data: CEL, EXP
Series
Accession:
GSE1621
ID:
200001621
13.
Full record GDS794

Cardiac hypertrophy progression: time course

Expression profiling of hearts from FVB males subjected to cardiac pressure overload by transverse aortic constriction (TAC). TAC performed on 3 month old males. Hearts examined 2, 10, and 21 days after surgery. Results provide insight into the progression of cardiac hypertrophy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL81
Series:
GSE1621
26 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS794
ID:
794
14.

CHF1/Hey2 Promotes Physiological Hypertrophy in response to Pressure Overload

(Submitter supplied) We have previously found that overexpression of CHF1/Hey2 in the myocardium prevents the development of phenylephrine-induced hypertrophy. To determine the role of CHF1/Hey2 in pressure overload hypertrophy, we performed ascending aortic banding on wild type and transgenic mice overexpressing CHF1/Hey2 in the myocardium. We found that both wild type and transgenic mice developed increased ventricular weight to body weight ratios one week after aortic banding. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE13031
ID:
200013031
15.

Caveolin-3 Knockout Hearts

(Submitter supplied) Energy Substrate Uptake and Metabolism are Preserved in Hypertrophic Caveolin-3 Knockout Hearts Keywords: gene knockout
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3552
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE10848
ID:
200010848
16.
Full record GDS3552

Caveolin-3 deficiency effect on hearts

Analysis of hearts lacking caveolin-3 (Cav3), the primary protein component of caveolae in muscle cells. Cav3 deficiency leads to cardiac hypertrophy and contractile dysfunction. Results provide insight into the molecular mechanisms underlying cardiac hypertrophy induced by Cav3 deficiency.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE10848
6 Samples
Download data: CEL
17.

Gene expression profiles in Sirt1/PPARalpha bigenic mice

(Submitter supplied) Cardiac-specific PPARalpha transgenic (Tg-PPARalpha) mice show mild cardiac hypertrophy and systolic dysfunction. The failing heart phenotypes observed in Tg-PPARalpha are exacerbated by crossing with cardiac-specific Sirt1 transgenic (Tg-Sirt1) mice, whereas Tg-Sirt1 mice themselves do not show any cardiac hypertrophy or systolic dysfunction. To investigate the mechanism leading to the failing heart phenotypes in TgPPARalpha/Tg-Sirt1 bigenic mice, microarray analyses were performed. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE33101
ID:
200033101
18.

Whole-transcriptome analysis identifies re-expression of fetal splice variants in cardiac hypertrophy

(Submitter supplied) Cardiac hypertrophy has been well-characterized at the level of transcription. During cardiac hypertrophy, genes normally expressed primarily during fetal heart development are re-expressed, and this fetal gene program is believed to be a critical component of the hypertrophic process. Recently, alternative splicing of mRNA transcripts has been shown to be temporally regulated during heart development, leading us to consider whether fetal patterns of splicing also reappear during hypertrophy.We hypothesized that patterns of alternative splicing occurring during heart development are recapitulated during cardiac hypertrophy. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL10669
9 Samples
Download data: TXT
Series
Accession:
GSE42411
ID:
200042411
19.

Cardiac muscle ring finger-1 increases susceptibility to heart failure by inhibiting creatine kinase activity in vivo

(Submitter supplied) Muscle ring finger-1 (MuRF1) is a muscle-specific protein implicated in the regulation of cardiac myocyte size and contractility. MuRF2, a closely related family member, redundantly interacts with protein substrates, and hetero-dimerizes with MuRF1. Mice lacking either MuRF1 or MuRF2 are phenotypically normal whereas mice lacking both proteins develop a spontaneous cardiac and skeletal muscle hypertrophy indicating cooperative control of muscle mass by MuRF1 and MuRF2. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2876
19 Samples
Download data: GPR
Series
Accession:
GSE11661
ID:
200011661
20.

Remodeling of the m6A landscape in the heart reveals conserved post-transcriptional events underlying cardiomyocyte hypertrophy

(Submitter supplied) Regulation of gene expression plays a fundamental role in cardiac stress-responses. Modification of coding transcripts by adenosine methylation (m6A) has recently emerged as a critical post-transcriptional mechanism underlying heart disease. Thousands of mammalian mRNAs are known to be m6A-modified, suggesting that remodeling of the m6A landscape may play an important role in cardiac pathophysiology. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
20 Samples
Download data: BED, CSV, TXT
Series
Accession:
GSE159243
ID:
200159243
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