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Items: 2

1.
Full record GDS2311

Estradiol effect on the ischemic brain

Analysis of ischemic cerebral cortices of ovariectomized animals on a regimen of 1 subcutaneous 17beta-estradiol pellet for 1 week. Ischemia was induced by middle cerebral artery occlusion. Results provide insight into the basis of estrogen's protective effect in experimental cerebral ischemia.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL85
Series:
GSE5315
4 Samples
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2.

Estrogen response after stroke

(Submitter supplied) Estrogen reduces brain injury after experimental cerebral ischemia in part through a genomic mechanism of action. Using DNA microarrays, we analyzed the genomic response of the brain to estradiol, and we identified a transcript, cocaine- and amphetamine-regulated transcript (CART), that is highly induced in the cerebral cortex by estradiol under ischemic conditions. Using in vitro and in vivo models of neural injury, we confirmed and characterized CART mRNA and protein up-regulation by estradiol in surviving neurons, and we demonstrated that i.v. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2311
Platform:
GPL85
4 Samples
Download data
Series
Accession:
GSE5315
ID:
200005315

Supplemental Content

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