GEO DataSets

Analysis of lungs of spontaneously hypertensive (SH) animals after exposure to 350 ppm sulfur dioxide 5 hours per day for 4 days. Results provide insight into the molecular and genetic basis of the greater susceptibility of SH animals to sulfur dioxide-induced airways disease.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 strain sets

Platform:

GPL341

Series:

GSE4702

16 Samples

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(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is diagnosed by airway obstruction and underlies a group of ailments such as bronchitis, emphysema and often asthma; however, rodent models do not resemble human pathology. Because genetically predisposed spontaneously hypertensive (SH) rats display phenotypes such as systemic inflammation, thrombosis, oxidative stress, and suppressed immune function, that are also apparent in COPD patients, we exposed SH and commonly used male Sprague Dawley (SD) to 0, 250, or 350 ppm sulfur dioxide (SO2), 5h/d for 4 consecutive days. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2372

Platform:

GPL341

16 Samples

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(Submitter supplied) Chronic obstructive pulmonary disease is a smoking-related disease that lacks effective therapies due partly to the poor understanding of disease pathogenesis. The aim of this study was to identify molecular pathways which could be responsible for the damaging consequences of smoking. To do this, we employed recently described bioinformatic methods to analyze differences in global gene expression, which we then related to the pathological changes induced by cigarette smoke (CS). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

209 Samples

Download data: CEL

(Submitter supplied) DEP exposure is linked to increases in cardiovascular effects. This effect is enhanced in individuals with pre-existing disease. Animal models of cardiovascular disease are used to study this susceptibility. The heart is rich in mitochondria, which produce high levels of free radicals, leading to inactivation of tricarboxylic acid cycle enzymes. We hypothesized that a 4-wk DEP inhalation would result in strain-related structural impairment of cardiac mitochondria and changes in these enzyme activities in WKY and SHR. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3689

Platform:

GPL341

16 Samples

Download data: CEL, CHP

Analysis of heart left ventricle from healthy animals exposed to diesel exhaust (DE) particles. Spontaneously hypertensive animals also examined. DE is linked to cardiovascular impairment. Results suggest DE exposure produces a hypertensive-like cardiac gene expression pattern in healthy animals.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state, 2 stress sets

Platform:

GPL341

Series:

GSE9694

16 Samples

Download data: CEL, CHP

(Submitter supplied) Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes that could play a role in airway remodeling associated with V2O5-induced bronchitis. Gene expression was measured at various time points over a 24 hr period using the Affymetrix Human Genome U133A 2.0 Array. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2535

Platform:

GPL571

45 Samples

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Analysis of lung fibroblasts for up to 24 hours following exposure to vanadium pentoxide (V2O5). Exposure to V2O5 is a cause of occupational bronchitis. Results provide insight into the molecular mechanisms that contribute to airway remodeling associated with V2O5-induced bronchitis.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 5 time sets

Platform:

GPL571

Series:

GSE5339

45 Samples

Download data