Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS2468

Soy and whey protein diets effect on colon tumorigenesis

Analysis of colons of soy or whey protein fed Sprague Dawley males 40 weeks after azoxymethane (AOM) injection to induce tumor formation. Lifetime consumption of soy or whey proteins reduces the incidence of AOM-induced colon tumors in rats.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol sets
Platform:
GPL85
Series:
GSE6102
9 Samples
Download data: CEL, EXP
2.

Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis

(Submitter supplied) We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet), soy protein isolate (SPI), and whey protein hydrolysate (WPH) diets were determined. We identified 31 induced and 49 repressed genes in the proximal colons of the SPI-fed group and 44 induced and 119 repressed genes in the proximal colons of the WPH-fed group, relative to CAS. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2468
Platform:
GPL85
9 Samples
Download data: CEL, EXP
Series
Accession:
GSE6102
ID:
200006102
3.

Dietary effect of SPI or Genistein alters rat mammary epithelial global gene expression profiles

(Submitter supplied) The role of diet in the prevention of breast cancer is widely accepted, yet little is known on how early dietary effects mitigate adult cancer risk. Soy consumption is associated with reduced breast cancer risk in women, an effect largely attributed to the soy isoflavone genistein (GEN). We previously showed lower chemically-induced mammary tumor incidence in young adult rats with lifetime dietary intake of soy protein isolate (SPI), a highly refined soy product in infant formula, than in those fed the control diet Casein (CAS). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2616
Platform:
GPL341
10 Samples
Download data: CEL
Series
Accession:
GSE6879
ID:
200006879
4.
Full record GDS2616

Mammary epithelial cell response to genistein and soy proteins

Analysis of mammary epithelial cells of females fed a diet containing the soy isoflavone genistein or soy protein isolate. Soy consumption is associated with reduced breast cancer risk in women. Results provide insight into the molecular basis of the beneficial effect of soy-rich diets.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 protocol sets
Platform:
GPL341
Series:
GSE6879
10 Samples
Download data: CEL
DataSet
Accession:
GDS2616
ID:
2616
5.

Different effects of 17 beta estrodial and soy protein isolate on bone gene expression in the pre-pubertal female rats

(Submitter supplied) Beneficial effects of a soy diet on bone quality have been assumed to be due to the putative estrogenic actions of isoflavones. We studied the effects of soy protein isolate (SPI) on bone quality and compared these effects to 17β-estradiol (E2) in pre-pubertal rats. Female rats were weaned to a control diet with or without E2 (0.1, 1, 10 µg/kg/d), or SPI-containing diet with or without E2 (10 µg/kg/d) for 14 days beginning on postnatal day 20. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL
Series
Accession:
GSE30862
ID:
200030862
6.

Effect of ingested whey protein hydrolysate on gene expression profiles compared to an identical composition of amino acid mixture in rat skeletal muscle

(Submitter supplied) We have previously showed that whey protein hydrolysate (WPH) causes a greater increase in muscle protein synthesis than an identical composition of amino acids mixture does. The present study was conducted to investigate a comparative effect of WPH on gene expression. Male Sprague-Dawley rats subjected to a 2-h swimming exercise were administered either a carbohydrate-amino acid diet or a carbohydrate-WPH diet immediately after exercise. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS5390
Platform:
GPL1355
8 Samples
Download data: CEL
Series
Accession:
GSE49486
ID:
200049486
7.
Full record GDS5390

Whey protein hydrolysate diet effect on exercised epitrochlearis muscle

Analysis of epitrochlearis muscle from males exercised for 2hr then fed a whey protein hydrolysate (WPH) diet or a control diet with an identical amino acid composition (AAM). Results provide insight into the molecular basis of the greater post-exercise muscle protein synthesis in the WPH group.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL1355
Series:
GSE49486
8 Samples
Download data: CEL
DataSet
Accession:
GDS5390
ID:
5390
8.

Mammary Gland Morphology and Gene Expression Signature of Prepubertal Male and Female Rats Following Exposure to Exogenous Estradiol

(Submitter supplied) In order to properly understand whether xenoestrogens act as estrogens, it is essential to possess a solid portrait of the physiological effects of exogenous estradiol. Because the estrogen-dependent gene expression is one of the primary biomarkers of estrogenic action, we have assessed effects of three doses of exogenous estradiol (0.1, 1.0 and 10 µg/kg of body weight/day) on the mammary gland morphology and gene expression profiles by microarray analysis of prepubertal male and female rats of both sexes compared to untreated controls. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE40713
ID:
200040713
9.

Changes in mammary gene expression and morphology following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17b-estradiol treatment

(Submitter supplied) Soy foods have been suggested to have both positive health benefits and potentially adverse effects largely as a result of their content of isoflavone phytoestrogens. Since soy protein isolate (SPI) contains isoflavones, in addition to purported health benefits, safety concerns have been raised regarding the use of SPI and soy formulas, because of potential estrogenic actions during the neonatal period, including the potential for reproductive toxicity, infertility, and the possibility of increased risk for development and recurrence of estrogen sensitive cancers such as breast cancer. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
12 Samples
Download data: CEL
Series
Accession:
GSE38060
ID:
200038060
10.

Fish oil/pectin temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis

(Submitter supplied) We have demonstrated that fish oil/pectin (FO/P) diets protect against colon cancer compared to corn oil/cellulose (CO/C) by upregulating apoptosis and suppressing proliferation. To elucidate the mechanisms whereby FO/P diets induce apoptosis and suppress proliferation during the tumorigenic process, we analyzed the temporal gene expression profiles from exfoliated rat colonocytes. KEYWORDS: Fish oil/pectin, pectin, exfoliated colonocytes, gene expression, apoptosis, colon cancer, chemoprevention
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL2896
89 Samples
Download data: TXT
Series
Accession:
GSE27266
ID:
200027266
11.

Dietary soy effects on early rat mammary gland development

(Submitter supplied) The linkage between nutrition and cancer prevention is an intriguing concept that is gaining widespread support based on epidemiological and animal studies. Multiple mechanisms likely underlie dietary protection against cancer, with effects influenced by target tissue response, cell-cell interactions and developmental context. Given the negative correlation between breast cancer incidence and intake of soy foods by Asian women, and the increasing consumption of soy protein-based formula by infants in the Western world, we have studied soy protein isolate (SPI) used in most infant formula as a paradigm to evaluate diet as a risk factor in a rodent model of mammary cancer. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
10 Samples
Download data: CEL
Series
Accession:
GSE12217
ID:
200012217
12.

Long-Term Soy Protein Isolate Intake Reduces Liver Steatosis through Changes in Global Gene Expression in Obese Zucker Rats

(Submitter supplied) To understand how soy protein isolate (SPI) reduced liver steatosis in male obese Zucker rats, we conducted global gene expression (RNAseq) analysis on liver samples of male rats fed either the SPI or a control casein (CAS)-based diet (n=8 per group) for 16 wks. Bioinformatics was conducted using Ingenuity Pathway Analysis (IPA) software (Qiagen, CA) with P < 0.05 and 1.3 fold differential expression cutoff values.
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22396
16 Samples
Download data: XLSX
Series
Accession:
GSE158553
ID:
200158553
13.

Comparison of Saffron and Photobiomodulation on the light damaged rat retina.

(Submitter supplied) Aim: To identify the genes and non-coding RNAs (ncRNAs) involved in the neuroprotective actions of a dietary anti-oxidant (saffron) and of photobiomodulation. Methods: We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12h 5 lux, 12h darkness) are challenged by 24h exposure to bright (1,000 lux) light. Experimental groups were protected against light damage by pretreatment with dietary saffron (1mg/kg/day for 21d) or photobiomodulation (10 J/cm2 at the eye, daily for 5d). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
18 Samples
Download data: CEL, CHP
Series
Accession:
GSE22818
ID:
200022818
14.

Genome-wide analysis of the rat colon reveals site-specific differences in histone modifications and proto-oncogene expression

(Submitter supplied) Goal: Since disease susceptibility of the intestine exhibits an anatomical bias, we propose that the chromatin landscape, especially the site-specific epigenetic differences in histone modification patterns throughout the longitudinal axis, contributes to a differential response to chemoprotective agents. Method: We assessed the chromatin structure associated with gene expression profiles in the rat proximal and distal colon by globally correlating chromatin immunoprecipitation next-generation sequencing analysis (ChIP-Seq) with mRNA transcription (RNA-Seq) data. more...
Organism:
Rattus norvegicus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL14844
7 Samples
Download data: BEDGRAPH, TXT
Series
Accession:
GSE49389
ID:
200049389
15.

Time dependent expression profiles of mRNAs and microRNAs in rat milk

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL16371 GPL4135
22 Samples
Download data: TXT
Series
Accession:
GSE44114
ID:
200044114
16.

Time dependent expression profiles of microRNAs in rat milk

(Submitter supplied) We have reported that microRNAs are present in human and bovine milk. But, it is unknown the roles of milk miRNAs. To clarify the roles of milk miRNAs, experimental animal such as rat study would be needed. However, it is unclear whether rat milk also contains miRNAs. Thus, we have employed microarray to show that rat milk also contains miRNAs.
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL16371
12 Samples
Download data: TXT
Series
Accession:
GSE44113
ID:
200044113
17.

Time dependent expression profiles of mRNAs in rat milk

(Submitter supplied) We have reported that mRNAs are present in bovine milk. But, it is unknown the roles of milk mRNAs. To clarify the roles of milk mRNAs, experimental animal such as rat study would be needed. However, it is unclear whether rat milk also contains mRNAs. Thus, we have employed microarray to show that rat milk also contains mRNAs.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL4135
10 Samples
Download data: TXT
Series
Accession:
GSE44112
ID:
200044112
18.

Assessment of Histone Tail Modifications and Transcriptional Profiling During Colon Cancer and Role of fish oil/pectin Diet Against Colon Carcinogen

(Submitter supplied) In an effort to gain insight into the extensive dimension of post-translational modifications in histones (including H3K4me3 and H3K9ac) and elucidate the chemoprotective impact of dietary bioactive compounds on transcriptional control in a colon cancer preclinical model, we generated high-resolution genome-wide RNA (RNA-Seq) and “chromatin-state” (H3K4me3-seq and H3K9ac-seq) maps for intestinal (epithelial colonocytes) crypts in rats treated with a colon carcinogen and fed bioactive (i) fish oil (ii) butyrate (in the form of a fermentable fiber a rich source of SCFA), (iii) a combination of fish oil plus butyrate or (iv) control diets. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18694
107 Samples
Download data: XLS
Series
Accession:
GSE87525
ID:
200087525
19.

Cocoa polyphenols and fiber modify colonic gene expression in rats

(Submitter supplied) Cocoa intake has been associated with health benefits, improving cardiovascular function and metabolism, as well as modulating intestinal immune function. The aim of this study was to take an in-depth look into the mechanisms affected by the cocoa intake by evaluating the colonic gene expression after nutritional intervention, and to ascertain the role of the fiber of cocoa in these effects. To achieve this, Wistar rats were fed for 3-weeks with either a reference diet, a diet containing 10% cocoa (C10), a diet based on cocoa fiber (CF) or a diet containing inulin (I). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL14797
8 Samples
Download data: TXT
Series
Accession:
GSE70950
ID:
200070950
20.

Comparison of microarray to RT-PCR

(Submitter supplied) mRNA used for the analysis of these microarrays were previously analyzed for 34 genes by reverse transcription - polymerase chain reaction in Desai BJ et al., J.Orthop.Trauma 17: 689-698, 2003. These two data sets were subsequently studied to compare the results from these two different methods for mRNA quantitation. The comparison was publised in "Comparison of mRNA gene expression by RT-PCR and DNA microarray" by W. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL85
10 Samples
Download data: CEL
Series
Accession:
GSE788
ID:
200000788
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=2|blobid=MCID_616b91a156e76b7be428fb1c|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center