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Links from GEO DataSets

Items: 19

1.
Full record GDS2577

Regenerating liver and developing embryonic liver comparison

Comparison of regenerating liver to developing embryonic liver. Regenerating liver examined at time points up to 72 hours after partial hepatectomy. Developing liver examined up to 16.5 days post conception (dpc). Results provide insight into molecular mechanisms regulating renewal and repair.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 specimen, 16 time sets
Platform:
GPL1261
Series:
GSE6998
32 Samples
Download data: CEL
DataSet
Accession:
GDS2577
ID:
2577
2.

Expression profiling of developmental and regenerating liver in mice

(Submitter supplied) Normal adult liver is uniquely capable of renewal and repair after injury. Whether this response represents simple hyperplasia of various liver elements or requires recapitulation of the genetic program of the developing liver is not known. To study these possibilities, we examined transcriptional programs of adult liver after partial hepatectomy and contrasted these with developing embryonic liver. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2577
Platform:
GPL1261
32 Samples
Download data: CEL
Series
Accession:
GSE6998
ID:
200006998
3.

MicroRNA implication in murine liver regeneration

(Submitter supplied) Liver is uniquely capable to repair itself after injury. Multiple molecular and biochemical processes initiated after partial hepatectomy, lead to proliferation of all cells within the liver. MicroRNAs (miRNAs) are a class of highly abundant non-coding RNA molecules that cause post-transcriptional gene repression and are involved in several biological processes including cell cycle regulation and differentiation. more...
Organism:
Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Human polyomavirus 1; Rattus norvegicus; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
2 Samples
Download data: TXT
Series
Accession:
GSE35128
ID:
200035128
4.

Characterization of hepatic gene expression during liver regeneration in response to partial hepatectomy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL81 GPL1261
81 Samples
Download data: CEL
Series
Accession:
GSE20427
ID:
200020427
5.

Hepatic gene expression during liver regeneration in response to partial hepatectomy: late time points (24h, 38h, 48h)

(Submitter supplied) The process of liver regeneration can be divided into a series of stages that include initial inductive or priming events through cellular mitosis. Following two-thirds liver resection, the liver undergoes the “priming” phase, in which cytokines TNF-a and IL-6 activate their respective receptors in hepatocytes. This leads to the activation of several key transcription factors: NF-kB, AP-1, Stat 3, Stat 1, and C/EBP-b and -d . more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
35 Samples
Download data: CEL
Series
Accession:
GSE20426
ID:
200020426
6.

Hepatic gene expression during liver regeneration in response to partial hepatectomy: early time points (0.5h,1h,2h,4h)

(Submitter supplied) The process of liver regeneration can be divided into a series of stages that include initial inductive or priming events through cellular mitosis. Following two-thirds liver resection, the liver undergoes the “priming” phase, in which cytokines TNF-a and IL-6 activate their respective receptors in hepatocytes. This leads to the activation of several key transcription factors: NF-kB, AP-1, Stat 3, Stat 1, and C/EBP-b and -d . more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
46 Samples
Download data: CEL
Series
Accession:
GSE20425
ID:
200020425
7.

Genome-wide analysis of gene expression of livers of wild type and IL-4/IL-13-/- mice after carbon tetrachloride-induced injury

(Submitter supplied) Global analysis of differentially expressed genes of livers of wild type and IL-4/IL-13-/- two days after carbon tetrachloride treatment.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5073
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE45002
ID:
200045002
8.
Full record GDS5073

IL-4 IL-13 double mutant liver response to acute injury

Analysis of livers of IL-4 IL-13 double mutants 2 days following treatment with carbon tetracholoride to induce acute liver injury. Results provide insight into the role of IL-4 and IL-13 in liver regeneration.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation sets
Platform:
GPL6885
Series:
GSE45002
8 Samples
Download data
9.

Multi-cellular Transcriptional Profiling Reveals an Epigenetic Barrier to Adult Heart Regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL17021
18 Samples
Download data
Series
Accession:
GSE95764
ID:
200095764
10.

Multi-cellular Transcriptional Profiling Reveals an Epigenetic Barrier to Adult Heart Regeneration [ATAC-Seq]

(Submitter supplied) Background - The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we construct a transcriptional atlas of multiple cardiac cell populations, which enables comparative analyses of the regenerative (neonatal) versus non-regenerative (adult) state for the first time. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE95763
ID:
200095763
11.

Multi-cellular Transcriptional Profiling Reveals an Epigenetic Barrier to Adult Heart Regeneration [RNA-Seq]

(Submitter supplied) Background - The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we construct a transcriptional atlas of multiple cardiac cell populations, which enables comparative analyses of the regenerative (neonatal) versus non-regenerative (adult) state for the first time. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE95762
ID:
200095762
12.

Multicellular Transcriptional Analysis of Mammalian Heart Regeneration

(Submitter supplied) The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we construct a transcriptional atlas of multiple cardiac cell populations, which enables comparative analyses of the regenerative (neonatal) versus non-regenerative (adult) state for the first time. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
64 Samples
Download data: TXT, XLSX
Series
Accession:
GSE95755
ID:
200095755
13.

Tob1 is a Constitutively Expressed Repressor of Liver Regeneration

(Submitter supplied) How proliferative and inhibitory cell signals integrate to control liver regeneration remains poorly understood. A screen for antiproliferative factors repressed after liver injury identified Tob1, a member of the PC3/BTG1 family of mitoinhibitory molecules as a target for further evaluation. Tob1 protein decreases after 2/3 hepatectomy in mice secondary to post-transcriptional mechanisms. Deletion of Tob1 increases hepatocyte proliferation and accelerates restoration of liver mass after hepatectomy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE21836
ID:
200021836
14.

Gene expression profiling of mouse liver regeneration after PHx

(Submitter supplied) Genome-wide expression analysis revealed that 3653 mRNAs and 465 putative lncRNAs were differentially expressed compared to transcripts isolated from livers of control sham operated mice. Analysis was done using the NCode Mouse Non-coding RNA Microarray (Invitrogen), which contains 25,179 coding featues and 10,802 noncoding features.
Organism:
Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platform:
GPL20668
25 Samples
Download data: TXT
Series
Accession:
GSE70593
ID:
200070593
15.

Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Other; Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL20668 GPL13112
40 Samples
Download data: BW
Series
Accession:
GSE70343
ID:
200070343
16.

LncPHx2 RNA-interactome

(Submitter supplied) LncPHx2 RNA-interactome study realed that LncPHx2 is associated with multiple RNAs
Organism:
Mus musculus
Type:
Other
Platform:
GPL13112
3 Samples
Download data: BW
17.

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

(Submitter supplied) Gene expression analysis showed that LncPHx2 depletion resulted in upregulation of mRNAs encoding proteins known to promote cell proliferation, including MCM components, DNA polymerases, histone proteins, and transcription factors
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: DIFF, FPKM_TRACKING
Series
Accession:
GSE70283
ID:
200070283
18.

Comparison of hepatic gene change after partial hepatectomy

(Submitter supplied) Partial hepatectomy, resection of a portion of liver mass, indues significant liver regenerative responses that consist of numerous genetic changes. To identify specific genetic changes, we compare the liver of mice underwent either hepatectomy or sham operation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE22879
ID:
200022879
19.

RNA polymerase III regulation during mammalian tissue regeneration

(Submitter supplied) There are about 600 loci in the mammalian genome that are annotated as RNA polymerase III genes. These comprise tRNA genes, the genes encoding 5S RNA, the smallest ribosomal RNA, and genes encoding catalytic or structural RNAs involved in processes as diverse as RNA processing or transcription elongation. Most RNA polymerase III genes have similar promoter structures, yet they are transcribed with different efficiencies. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
29 Samples
Download data: BW, XLSX
Series
Accession:
GSE114650
ID:
200114650
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