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Links from GEO DataSets

Items: 20

1.
Full record GDS2682

Conjunctiva and cornea comparison

Analysis of conjunctival (Cnj) and corneal (Co) epithelia, the main cellular components of the ocular surface. Cnj and Co epithelia are embryologically related but phenotypically and functionally disparate. Results provide insight into the molecular basis of these differences.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE5543
6 Samples
Download data
2.

Gene Expression in Human Conjunctiva and Cornea

(Submitter supplied) PURPOSE. To determine global mRNA expression levels in the corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS. cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide array representing > 22,000 transcripts. The resulting signal intensities and transcript present/absent calls by the primary microarray analyzing software were used in conjunction with a statistical method to identify transcripts that are preferentially or exclusively (transcripts absent in all three replicates in the other tissue) and significantly (expression >1% of the ß-actin level) expressed in one of the two tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2682
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE5543
ID:
200005543
3.

Comparative gene expression in the human conjunctiva and cornea

(Submitter supplied) The identification of a marker that is expressed in the conjunctival epithelium but not in the corneal epithelium has been a growing need. A more specific marker of limbal and conjunctival epithelia would be necessary to detect non-corneal epithelial cells on the corneal surface. To search for conjunctival specific marker(s), we first performed preferential gene profiling in the conjunctiva in direct comparison to that in the cornea using microarray technique.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE29402
ID:
200029402
4.

Molecular profiling of the of conjunctival epithelial side population cells

(Submitter supplied) Side population (SP) cells isolated from limbal and conjunctival epithelia derive from cells that are slow cycling in vivo, a known feature of tissue stem cells. The purpose of this study was to define the molecular signature of the conjunctival side population cells by global differential gene expression to identify markers and signaling pathways associated with this cell phenotype. Four overnight cultures of freshly isolated human conjunctival epithelial cells stained with Hoechst 3342 were cytometrically sorted into SP and non-SP cohorts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE12631
ID:
200012631
5.

Effect of Retinoic Acid on Gene Expression in Human Conjunctival Epithelial Cell Line

(Submitter supplied) Purpose. How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. We sought to identify vitamin A responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial cell line (HCjE) grown with all-trans-retinoic acid (RA). The analysis showed that the membrane-associated mucin MUC16 was induced by RA and that secretory phospholipase A2 Group IIA (sPLA2-IIA), the gene most upregulated by RA, was induced earlier. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
12 Samples
Download data
Series
Accession:
GSE2835
ID:
200002835
6.

Comparative gene expression in the limbus of the vervet monkey

(Submitter supplied) The limbus is a unique anatomic structure that is highly innervated and vascularized yet sets the boundary for the avascularized cornea. The corneal epithelial stem cells are believed to reside at the limbus. The intrinsic and external molecular signals that modulate the differentiation and proliferation of the limbal stems cells are still largely unidentified because of a lack of known specific markers. more...
Organism:
Homo sapiens; Chlorocebus sabaeus
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL
Series
Accession:
GSE10683
ID:
200010683
7.

Mouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4

(Submitter supplied) Purpose: To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 around eye opening stage when the goblet cells first appear. Methods: Laser-capture-microdissection was used to collect conjunctival forniceal epithelial cells from postnatal-day (PN) 9, PN14 and PN20 wild-type (WT), and PN14 Klf4-conditional null (Klf4CN) mice, where goblet cells are absent, developing, present, and missing, respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, TXT
Series
Accession:
GSE26076
ID:
200026076
8.

Lens Epithelial Cells and Lens Cortical Fiber Cells

(Submitter supplied) Total RNA was isolated from three separate populations of human lens epithelial cells and three matching populations of lens cortical fiber cells. All samples were analyzed on separate microarrays. Keywords: repeat sample
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1327
Platform:
GPL96
6 Samples
Download data
Series
Accession:
GSE2256
ID:
200002256
9.
Full record GDS1327

Lens epithelial and lens cortical fiber cell comparison

Comparison of lens epithelial cells to lens cortical fiber cells. Cells microdissected from lenses of post mortem donors. Results identify genes that may play roles in maintaining the specialized functions of each cell type and provides insight into potential mechanisms of lens cell differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL96
Series:
GSE2256
6 Samples
Download data
10.

Gene Expression Profiling In Murine Corneal Neovascularization Models

(Submitter supplied) In order to find out the vital genes during the corneal neovascularization (CNV), we set up two CNV models, one being induced by suture placement and the other by alkali burn to the corneal center. Young adult Balb/c and C57BL/6 were used. The corneas were checked daily for CNV development and some of the corneas were removed at two pre-determined time points for RNA extraction. Preliminary experiment indicated slightly different dynamics in suture- or chemical burn-induced CNV. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10745
12 Samples
Download data: LSR
Series
Accession:
GSE23347
ID:
200023347
11.

Gene expression profile of conjunctival epithelial cell lines

(Submitter supplied) Human conjunctival cell lines are useful tools for modeling ocular surface disease and evaluation of ocular drugs. Here we demonstrate that the IOBA-NHC and the ChWK conjunctival epithelial cell lines show, using an unbiased gene microarray approach, unique gene expression signatures that differ from primary conjunctival epithelial cells (PCEC) and conjunctival tissue. Globally, the expression profile obtained with the Affymetrix U133A chip (>22000 genes) from PCEC was clustered more closely to conjunctival tissue than either of the 2 cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
16 Samples
Download data: CEL
Series
Accession:
GSE8633
ID:
200008633
12.

Gene expression profile of the SV40-immortalized human corneal epithelial cells

(Submitter supplied) Microarray was used to study global gene expression of a cell culture model based on SV40-immortalized human corneal epithelial (iHCE) cells. The gene expression profile of the cell line was compared to the normal human corneal epithelium. Affymetrix HG-U133A GeneChips® were used for microarray experiments and results were validated by performing RT-qPCR for selected genes. iHCE was found to over- and under-express 22 % and 14 % of the annotated genes, respectively. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
3 Samples
Download data: CEL
Series
Accession:
GSE22539
ID:
200022539
13.

Limbal and Central Corneal Epithelia

(Submitter supplied) Limbal and central regoins of the rat cornea epithelium were used to constract 2 SAGE libraries, in order to identify candidate genes to distinguish stem cell from differentiated central cornea epithelium cells. Keywords: gene expression SAGE-based, count
Organism:
Rattus norvegicus
Type:
Expression profiling by SAGE
Platform:
GPL23
2 Samples
Download data
Series
Accession:
GSE4121
ID:
200004121
14.

Dihydrotestosterone induced changes in gene expression in immortalized human conjunctival epithelial cells

(Submitter supplied) Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in immortalized human conjunctival epithelial cells. Analysis of regulation of immortalized human conjunctival epithelial cells by dihydrotestosterone at gene expression level. The hypothesis tested in the present study was that the androgen-eye interaction in ocular surface epithelial cells like conjunctival cells is influenced by androgens through regulation of the expression of multiple genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE18094
ID:
200018094
15.

Dihydrotestosterone induced changes in gene expression in immortalized human meibomian gland epithelial cells

(Submitter supplied) Genome-wide analysis of dihydrotestosterone (DHT) induced changes in gene expression in immortalized human meibomian gland epithelial cells. Analysis of regulation of immortalized human meibomian gland epithelial cells by dihydrotestosterone at gene expression level. The hypothesis tested in the present study was that the androgen-eye interaction in ocular surface epithelial cells like meibomian gland cells is influenced by androgens through regulation of the expression of multiple genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE18091
ID:
200018091
16.

Expression data from LCM captured prostate cancer cells

(Submitter supplied) The prostate represents a complex mix of cell types and there is a need to analyze distinct cell populations to better understand their potential interactions. This study of cell-type specific gene expression patterns will contribute to understanding of how tumor epithelial cells may be affected by adjacent interstitial stromal cells within the tumor microenvirnonment. LCM and microarray analysis were used to identify gene expression patterns in prostate cancer epithelial and interstitial stromal cell populations. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE20758
ID:
200020758
17.

Comparative transcriptional profiling of Limbal Epithelial Crypts with rest of the ocular surface epithelial regions.

(Submitter supplied) Recently we had discovered a solid cord like structure at the limbus of human eyes, termed as the Limbal Epithelial Crypt (LEC). It arises from the undersurface of the interpalisade rete ridges and extends towards the conjunctiva over the conjunctival stroma. Anatomical and immunohistochemical studies have shown it to be potentially a Stem Cell Niche. To confirm this hypothesis we conducted comparative gene expression profile of LEC with pathway and Geneontology studies in comparison with other ocular surface epithelial regions such as cornea, limbus, LEC stroma and conjunctiva. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL9677
18 Samples
Download data: GPR
Series
Accession:
GSE19035
ID:
200019035
18.

Serial analysis of gene expression in the corneal endothelium of Fuchs' dystrophy

(Submitter supplied) PURPOSE: To compare the gene expression profiles of normal human corneal endothelium with Fuchs' corneal endothelium, by using serial analysis of gene expression (SAGE). METHODS: Three pairs of normal human corneas were obtained from eye banks. Thirteen bisected Fuchs' corneal buttons were processed at the time of corneal transplantation. The endothelia of normal and Fuchs'-affected corneas were stripped, and total RNA was isolated. more...
Organism:
Homo sapiens
Type:
Expression profiling by SAGE
Platform:
GPL4
2 Samples
Download data
Series
Accession:
GSE505
ID:
200000505
19.

Gene Expression Analysis of the Rat Retina during Maturation

(Submitter supplied) Recently we reported that the rat inner retina undergoes significant functional changes during maturation. Aiming to gain knowledge on additional aspects of retinal development and maturation, we used the microarray system to monitor gene expression patterns in the rat retina at ages 5, 11, and 20 weeks. The analysis revealed the expression of many well-documented retinal genes as well as a high number of non–annotated genes. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL890
4 Samples
Download data: GPR
Series
Accession:
GSE8423
ID:
200008423
20.

The in vivo effect of actin cytoskeletal abnormalities on gene expression

(Submitter supplied) Remodeling of the actin cytoskeleton through actin dynamics (assembly and disassembly of filamentous actin) is known to be essential for numerous basic biological processes. In addition, recent in vitro studies provided evidence that actin dynamics participate in the control of gene expression. A spontaneous mouse mutant, corneal disease 1 (corn1), is deficient for a regulator of actin dynamics, destrin (DSTN; also known as actin depolymerizing factor or ADF), and develops epithelial hyperproliferation and neovascularization in the cornea. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE9743
ID:
200009743
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