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Items: 4

1.
Full record GDS2704

Transcription factor CHF1/Hey2 null smooth muscle cell response to platelet-derived growth factor: time course

Analysis of CHF1/Hey2 null aortic smooth muscle cells treated for up to 480 minutes with platelet-derived growth factor (PDGF). CHF1/Hey2 is a cardiovascular transcription factor. Results provide insight into the mechanisms regulated by CHF1/Hey2 in the response of smooth muscles to growth factors.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation, 8 time sets
Platform:
GPL1261
Series:
GSE6526
16 Samples
Download data: CEL
DataSet
Accession:
GDS2704
ID:
2704
2.

Expression time course data HEY2 KO and WT MASMC treated with PDGF

(Submitter supplied) The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild type and knockout smooth muscle cells after stimulation with platelet derived growth factor. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2704
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE6526
ID:
200006526
3.

CHF1/Hey2 Promotes Physiological Hypertrophy in response to Pressure Overload

(Submitter supplied) We have previously found that overexpression of CHF1/Hey2 in the myocardium prevents the development of phenylephrine-induced hypertrophy. To determine the role of CHF1/Hey2 in pressure overload hypertrophy, we performed ascending aortic banding on wild type and transgenic mice overexpressing CHF1/Hey2 in the myocardium. We found that both wild type and transgenic mice developed increased ventricular weight to body weight ratios one week after aortic banding. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE13031
ID:
200013031
4.

Transcription Factor CHF1/Hey2 Regulates Specific Gene Sets in Serum Stimulated Primary Cardiac Myocytes

(Submitter supplied) Background: We have previously found that overexpression of CHF1/Hey2 in the myocardium prevents the development of phenylephrine-induced hypertrophy and promotes physiological hypertrophy in an aortic banding model. To identify transcriptional pathways regulated by CHF1/Hey2 in hypertrophy, we cultured primary neonatal mouse cardiac myocytes from wild type and transgenic mice overexpressing CHF1/Hey2 and treated them with serum, a potent hypertrophic stimulus. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
25 Samples
Download data: CEL
Series
Accession:
GSE14288
ID:
200014288
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