GEO DataSets

Analysis of kidneys from Dahl salt-sensitive males fed a high salt diet. The Dahl salt sensitive animal is used as a model of hypertension. Results combined with quantitative trait loci analyses to identify candidate genes that influence blood pressure levels.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL1355

Series:

GSE4800

6 Samples

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(Submitter supplied) Male Dahl salt sensitive and Lewis rats (n=3 each) were fed an 8% NaCl diet starting at 5 weeks of age for 8 weeks. Total RNA was isolated with TRIzol reagent from DS and LEW kidneys and was subjected to microarray analysis. Keywords: animals with different genetic background comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2710

Platform:

GPL1355

6 Samples

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(Submitter supplied) Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identification of 16 different genomic regions that contain one or more BP quantitative trait loci (QTLs). The proximal region of rat chromosome 1 contains multiple BP QTLs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1350 GPL2796

19 Samples

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(Submitter supplied) Substitution of chromosome 13 from Brown Norway BN/SsNHsd/Mcw (BN/Mcw) rats into the Dahl salt-sensitive SS/JrHsd/Mcw (SS/Mcw) rats resulted in substantial reduction of blood pressure salt sensitivity in this consomic rat strain designated SSBN13. In the present study, we attempted to identify genes associated with salt-sensitive hypertension by utilizing a custom, known-gene cDNA microarray to compare the mRNA expression profiles in the renal medulla (a tissue playing a pivotal role in long-term blood pressure regulation) of SS/Mcw and SSBN13 rats on either low-salt (0.4% NaCl) or high-salt (4% NaCl, 2 wk) diets. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3076

24 Samples

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(Submitter supplied) The results of this study identified a number of pathways potentially important for the amelioration of hypertension and renal injury in SS-13BN/Mcw rats, and these results generated a series of testable hypotheses related to the role of the renal medulla in the complex mechanism of salt-sensitive hypertension. Keywords: time course, microarray; 11ß-hydroxysteroid dehydrogenase; glucagon receptor; extracellular matrix; apoptosis

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3061

24 Samples

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(Submitter supplied) We used high density oligonucleotide arrays to measure the relative expression levels of ~27,000 probe sets in the left ventricles of inbred rat strains; DA (high performing), Copenhagen (COP, low performing), as well as F1(COPxDA) rats bred from these two strains whose performance was intermediate relative to both parental strains. DA and COP rats differ for both intrinsic aerobic running capacity (assessed with a treadmill exercise test to exhaustion) and intrinsic cardiac performance (as assessed by the Langendorff-Neeley working heart model). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS778 GDS779 GDS780

Platforms:

GPL86 GPL87 GPL85

36 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL87

Series:

GSE1795

12 Samples

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Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL86

Series:

GSE1795

12 Samples

Download data

Expression profiling of heart left ventricles from 15 week old inbred COP, DA, and COP x DA F1 offspring (low, high, and intermediate performers respectively). Results provide insight into mechanisms underlying aerobic capacity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 strain sets

Platform:

GPL85

Series:

GSE1795

12 Samples

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(Submitter supplied) Kidney samples from three Dahl Salt-sensitive S rats were compared with kidney samples from three S.R(9)x3A congenic rats. Keywords = Blood Pressure Keywords = Quantitative trait locus Keywords = QTL Keywords = hypertension Keywords = rat Keywords = congenic Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1545 GDS1546 GDS1547

Platforms:

GPL85 GPL87 GPL86

18 Samples

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Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL87

Series:

GSE1775

6 Samples

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Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL86

Series:

GSE1775

6 Samples

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Comparison of kidneys from a hypertensive salt-sensitive strain and a congenic salt-resistant strain, with much lower blood pressure (BP). Expression of genes located in the 2.4 cM BP quantitative trait locus (QTL) interval on chromosome 9 examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL85

Series:

GSE1775

6 Samples

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(Submitter supplied) Rat kidney in normo- and hypotensive animals. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1251

Platform:

GPL341

9 Samples

Download data: CEL, EXP, RPT

Expression profiling of kidneys of 12 week old normotensive Wistar-Kyoto males subjected to acute hypotension by withdrawing 3 ml of blood. Results provide insight into vasoregulatory mechanisms and the genetics and physiology of blood pressure regulation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL341

Series:

GSE2401

9 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Genetic dissection of the S rat genome has provided strong evidence for the presence of two interacting blood pressure (BP) quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown. Further experiments targeted to identify the interacting genetic factors by the substitution mapping approach alone are difficult because of the interdependency of natural recombinations to occur at the two QTLs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL5126 GPL5127

30 Samples

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(Submitter supplied) To compare the tumor susceptibility between the hypertensive Dahl salt-sensitive rats (S) rat and S.LEW(10)x12x2x3x5 (S.LEW) congenic strain, one of the S.LEW congenic strains our laboratory previously constructed on rat chromosome 10 [Hypertension. 2007 Nov;50(5):891-8], Azoxymethane (AOM)-induced colon tumorigenesis in rats was assessed. At six weeks of age, both S and S.LEW congenic rats received intraperitoneal (IP) injection of AOM in sterial saline at a dose of 15mg/kg body weight once a week for two consecutive weeks. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14746

6 Samples

Download data: TXT

(Submitter supplied) Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for treatment. The genetically hypertensive “blood pressure high” (BPH), normotensive “blood pressure normal” (BPN), and hypotensive "blood pressure low" (BPL) inbred mouse strains are an ideal system to study differences in gene expression patterns that may represent such biological pathways. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3672 GDS3673 GDS3674 GDS3675

Platform:

GPL9734

67 Samples

Download data: CEL

Analysis of kidney of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the kidney.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

14 Samples

Download data: CEL

Analysis of liver of genetically hypotensive BPL, normotensive BPN, and hypertensive BPH inbred strains. Results provide insight into the molecular pathways affected by hypertension in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL9734

Series:

GSE19817

15 Samples

Download data: CEL