GEO DataSets

Analysis of brain at various time points up to 21 days following lateral fluid percussion-induced brain injury. Delayed cell death following trauma results in brain damage. Results provide insight into the mechanisms underlying brain damage after traumatic injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 7 time sets

Platform:

GPL85

Series:

GSE2392

39 Samples

Download data: CEL

(Submitter supplied) Summary: Brain trauma is a major cause of morbidity and mortality, both in adult and pediatric populations. Much of the functional deficit derives from delayed cell death resulting from induction of neurotoxic factors that overwhelm endogenous neuroprotective responses. Hypothesis: Gene expression profiling across species and models may help identify candidate molecular pathways induced by brain injury, some of which may provide novel targets for therapeutic intervention. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2850 GDS2851

Platforms:

GPL85 GPL81

61 Samples

Download data: CEL

Analysis of brain at various time points up to 72 hours following lateral controlled cortical impact injury. Delayed cell death following trauma results in brain damage. Results provide insight into the mechanisms underlying brain damage after traumatic injury.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 5 time sets

Platform:

GPL81

Series:

GSE2392

22 Samples

Download data: CEL

(Submitter supplied) Time dependent-profiles in the gene expression level following lateral moderate fluid percussion injury in the rat brain We used microarray to elucidate relationship between the alteration of gene expression levels and the progression of brain damages following traumatic brain injury.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS4911

Platform:

GPL1355

16 Samples

Download data: CEL

Analysis of lateral cortices of brains from Wistar males for up to 48 hours following traumatic brain injury (TBI). TBI induced by lateral moderate fluid percussion. Results provide insight into the nature of temporal events that occur at the molecular level following TBI.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 shock, 4 time sets

Platform:

GPL1355

Series:

GSE24047

16 Samples

Download data: CEL

(Submitter supplied) Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring during this secondary phase of injury is needed. This study was aimed at analysing gene expression patterns following cerebral cortical contusion in rat using high throughput microarray technology with the goal of identifying genes involved in an early and in a more delayed phase of trauma, as genomic responses behind secondary mechanisms likely are time-dependent. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

7 Samples

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(Submitter supplied) Comparison of gene expression in the hippocampus of 10 day old sham-injured and brain-injured BALB-c mice, and examine the effects of high dose Epo on these conditions at 24 hours following injury.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

24 Samples

Download data: CEL