GEO DataSets

Analysis of normal lung epithelial HPL1D cells and lung adenocarcinoma A549 cells treated with TGF-beta for up to 12 hours. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells but acts as a pro-tumor cytokine by promoting tumour angiogenesis, immune-escape, and metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 2 cell line, 3 time sets

Platform:

GPL3515

Series:

GSE7436

12 Samples

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(Submitter supplied) TGF-beta is one of the key cytokines implicated in various disease processes including cancer. TGF-beta inhibits growth and promotes apoptosis in normal epithelial cells and in contrast, acts as a pro-tumour cytokine by promoting tumour angiogenesis, immune-escape and metastasis. It is not clear if various actions of TGF-beta on normal and tumour cells are due to differential gene regulations. Hence we studied the regulation of gene expression by TGF-beta in normal and cancer cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2932

Platform:

GPL3515

12 Samples

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(Submitter supplied) To identify signaling pathways that are differentially regulated in human gliomas, a microarray analysis on 30 brain tumor samples (12 primary glioblastomas (GBM), 3 secondary glioblastomas (GBM-2), 8 astrocytomas (Astro) and 7 oligodendrogliomas (Oligo)) and on 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149) was performed. Normal brain tissue (NB) and normal human astrocytes (NHA) were used as a control. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4467 GDS4468

Platform:

GPL570

45 Samples

Download data: CEL

Analysis of 5 glioblastoma cell lines (LN018, LN215, LN229, LN319 and BS149). Results provide insight into molecular mechanisms underlying glioblastoma multiforme and other aggressive brain cancers.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 cell line sets

Platform:

GPL570

Series:

GSE15824

10 Samples

Download data: CEL

Analysis of primary glioblastomas (GBM), astrocytomas, oligodendrogliomas and secondary GBM brain tumors. MNK1 kinase upregulation observed in primary GBM brain tumors. Results identifiy signaling pathways differentially regulated in gliomas.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 5 cell type, 8 other, 3 tissue sets

Platform:

GPL570

Series:

GSE15824

35 Samples

Download data: CEL

(Submitter supplied) Subpopulations of primary Human Mammary Epithelial Cells (HMEC) have the unique ability to escape a period of growth arrest and continue to proliferate. These cells, called post-selection or variant cells (vHMEC), share features with premalignant breast cancer lesions, including p16INK4A promoter hypermethylation. Epigenetic silencing of tumour suppressor genes through DNA methylation and histone modification is an early event in tumorigenesis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3348

6 Samples

Download data: TXT

(Submitter supplied) A Transcriptomics Approach to Study the Biocompatibility and Finding out the Potential Applications of Magnetite (Fe3O4) Nanoparticles Here in this study, we examine the molecular effects of uptake of Fe3O4 nanoparticles using a whole genome microarray study in human epithelial cancer cell line. 38 genes (55%) out of 69 downregulated genes were found to be associated with TGF-beta or BMP signaling including six genes, Id1, Id2, Id3, Caspase-9, Smad6 and SMAD7, important negative regulators of these signaling pathways involved in development and tumorigenesis.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6102

6 Samples

Download data: TXT

(Submitter supplied) Yeast Hog1-3HA ChIP-Chip in triplicate Keywords: ChIP-Chip

Organism:

Saccharomyces cerevisiae

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL1689

3 Samples

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(Submitter supplied) This study was performed to characterize the gene expression profile of rat peritoneal mesothelioma (RPM) formation following treatment of Fischer 344 rats with o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). Keywords: Rat, Mesotheliomas, Bromochloractetic acid, o-Nitrotoluene, Carcinogenesis, Microarray

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2051

Platform:

GPL890

16 Samples

Download data: TIFF, TXT

Analysis of peritoneal mesotheliomas induced by various concentrations of o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). o-NT is a high production chemical. BCA is a by-product of drinking water disinfection. Results provide insight into the mechanisms underlying mesothelioma formation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log10 ratio, 2 agent, 5 dose sets

Platform:

GPL890

Series:

GSE4682

16 Samples

Download data: TIFF, TXT

(Submitter supplied) We have undertaken a screen of mouse limb tendon cells in order to identify molecular pathways involved in tendon development. Mouse limb tendon cells were isolated based on Scleraxis (Scx) expression at different stages of development: E11.5, E12.5 and E14.5 Microarray comparisons were carried out between tendon progenitor and differentiated stages.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5642

Platform:

GPL1261

9 Samples

Download data: CEL, CHP

Analysis of tendon cells isolated by FACS from forelimbs of embryonic day 11.5, E12.5 and E14.5 scleraxis (Scx)-GFP embryos. Basic helix-loop-helix transcription factor Scx is a specific tendon and ligament marker. Results provide insight into molecular pathways involved in tendon development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL1261

Series:

GSE54207

9 Samples

Download data: CEL, CHP

(Submitter supplied) We generated the transcriptional regulatory footprint of phthalimide neovascular factor 1 (PNF1)—a novel synthetic small molecule that exhibits significant in vitro endothelial potency and significant in vivo microvascular network expansion—by performing comparative microarray analysis on PNF1-stimulated (versus control) human microvascular endothelial cells (HMVEC) spanning 1-48 h post-supplementation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

14 Samples

Download data: CEL