Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 16

1.
Full record GDS3006

Primordial ovarian follicle development

Analysis of ovaries with unassembled, primordial, and primary follicles. Abnormal primordial follicle development can cause pathologies such as premature ovarian failure. Results provide insight into molecular mechanisms underlying primordial follicle assembly and transition to primary follicles.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 3 development stage, 3 protocol sets
Platform:
GPL85
Series:
GSE9300
6 Samples
Download data: CEL
DataSet
Accession:
GDS3006
ID:
3006
2.

Alterations in the ovarian transcriptome during primordial follicle assembly and development.

(Submitter supplied) The assembly of the developmentally arrested primordial follicle and subsequent transition to the primary follicle are poorly understood processes critical to ovarian biology. Abnormal primordial follicle development can lead to pathologies such as premature ovarian failure. The current study used a genome-wide expression profile to investigate primordial follicle assembly and development. Rat ovaries with predominantly unassembled, primordial, or primary follicles were obtained. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3006
Platform:
GPL85
6 Samples
Download data: CEL
Series
Accession:
GSE9300
ID:
200009300
3.

Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition.

(Submitter supplied) The oocytes found within the primordial follicles of mammalian ovaries remain quiescent for months to years until they receive the appropriate signals to undergo the primordial to primary follicle transition and initiate folliculogenesis. The molecular mechanisms and extracellular signaling factors that regulate this process remain to be fully elucidated. The current study investigates the mechanisms utilized by anti-Müllerian hormone (AMH; i.e. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3199
Platform:
GPL1355
4 Samples
Download data: CEL
Series
Accession:
GSE10557
ID:
200010557
4.
Full record GDS3199

Anti-Mullerian hormone effect on ovary

Analysis of postnatal day 4 ovaries cultured with anti-Mullerian hormone (AMH) for 10 days. AMH is an extracellular signaling molecule that inhibits the primordial to primary follicle transition in ovary. Results provide insight into molecular mechanisms underlying primordial follicle development.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1355
Series:
GSE10557
4 Samples
Download data: CEL
5.

Interactions Between Progesterone and Tumor Necrosis Factor-alpha in the Regulation of Primordial Follicle Assembly

(Submitter supplied) Follicle assembly is the process by which groups or ‘nests’ of oocytes break down to form primordial follicles. The size of the primordial follicle pool is the major determinant of the reproductive lifespan of a female. Previously, progesterone (P4) has been shown to inhibit follicle assembly, while tumor necrosis factor alpha (TNF-alpha) has been shown to promote the apoptosis that is necessary for follicle assembly. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2783
Platform:
GPL1355
4 Samples
Download data: CEL
Series
Accession:
GSE8238
ID:
200008238
6.
Full record GDS2783

Progesterone effect on cultured neonatal ovaries

Analysis of cultured neonatal ovaries treated with progesterone for 2 days. In the early postnatal period, groups of oocytes break down to form primordial follicles. This process is called follicle assembly. Results provide insight into the role of progesterone in follicle assembly.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1355
Series:
GSE8238
4 Samples
Download data: CEL
7.

Glial derived neurotrophic factor promotes ovarian primordial follicle development during folliculogenesis

(Submitter supplied) Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from four-day old female rat pups were maintained in organ culture for ten days in the absence (control) or presence of GDNF or kit ligand/stem cell factor (KL). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL1355
4 Samples
Download data: CEL
Series
Accession:
GSE11133
ID:
200011133
8.

Inhibitory Actions of Anti-Müllerian Hormone (AMH) on Ovarian Primordial Follicle Assembly

(Submitter supplied) The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH) on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly, decrease the initial primordial follicle pool size and promote the persistence of small oocyte nests in a rat ovarian organ culture. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE25629
ID:
200025629
9.

Induction of Ovarian Primordial Follicle Assembly by Connective Tissue Growth Factor CTGF

(Submitter supplied) Primordial follicle assembly is a process that occurs in the embryonic or early post natal ovary in which oocyte nests break down to form individual primordial follicles. The size of this initial pool of primordial follicles in part determines the reproductive lifespan of the female. Connective tissue growth factor (CTGF) was identified as a potential regulatory candidate for this process in a previous microarray analysis of follicle development. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE22096
ID:
200022096
10.

Gene Bionetwork Analysis of Ovarian Primordial Follicle Development

(Submitter supplied) Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth factors known to influence primordial follicles were used to construct a bionetwork of regulatory genes involved in primordial follicle development. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4048
Platform:
GPL6247
44 Samples
Download data: CEL
Series
Accession:
GSE20324
ID:
200020324
11.
Full record GDS4048

Ovarian primordial follicle response to various growth factors

Analysis of P4 ovaries of Sprague-Dawley females exposed to growth factors. Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. Results provide insight into molecular mechanisms underlying primordial follicle development.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 10 agent sets
Platform:
GPL6247
Series:
GSE20324
44 Samples
Download data: CEL
12.

Gene Bionetworks that Regulate Ovarian Primordial Follicle Assembly

(Submitter supplied) Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocytes for ovulation during a female’s reproductive life. Complex networks of cellular signaling and gene expression are essential for any biological process. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
27 Samples
Download data: CEL
Series
Accession:
GSE43464
ID:
200043464
13.

Neurotrophin NT3 promotes ovarian primordial to primary follicle transition

(Submitter supplied) Neurotrophins are growth factors that are known to have a role in promoting cell survival and differentiation. The focus of the current study is to examine the role of neurotrophins in regulating ovarian primordial follicle development. Ovaries from 4-day old rats were placed into organ culture and cultured for 10 days in the absence or presence of neurotrophin-3 (NT3), brain-derived neurotrophic factor (BDNF), or nerve growth factor (NGF). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3624
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE20358
ID:
200020358
14.
Full record GDS3624

Neurotrophin-3 effect on ovaries in vitro

Analysis of 4 day old ovaries cultured in the presence of neurotrophin-3 (NT3) for 2 days. Neurotrophins are growth factors involved in promoting cell survival and differentiation. Results provide insight into the role of NT3 in ovarian primordial follicle development.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL1355
Series:
GSE20358
6 Samples
Download data: CEL
15.

Age-related changes in gene expression patterns of immature and aged rat primordial follicles

(Submitter supplied) Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are not fully understood. In our recent work we observed a decline in BRCA1 mediated DNA repair in aging rat primordial follicles. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE84333
ID:
200084333
16.

Single-cell RNA sequence of ovarian tissues at E16.5, postnatal day 0 (PD0) and postnatal day 3 (PD3) with C57/BL6J mouse

(Submitter supplied) The ovarian tissues at E16.5, postnatal 0 day (PD0 ) and 3 days (PD3) in mice were collected to perform single-cell RNA sequence (scRNA-seq) in this study. The transcriptome landscape of different cell types contributed to discern the intrinsic mechanism of early folliculogenesis, and the developmental stage-specific germline and somatic cells were defined to reveal their genetic programs along with follicle development as well as their regulative molecules and interaction signals. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
3 Samples
Download data: TXT
Series
Accession:
GSE134339
ID:
200134339
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_61779be13f06b12cee69ba66|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center