GEO DataSets

Analysis of alcohol resistant and sensitive strains. Strains generated by artificial selection for alcohol sensitivity over multiple generations. Results provide insight into the molecular basis of alcohol sensitivity.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 gender, 2 other, 3 strain sets

Platform:

GPL1322

Series:

GSE7614

24 Samples

Download data: CEL, CHP

(Submitter supplied) Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS3072

Platform:

GPL1322

24 Samples

Download data: CEL, CHP

(Submitter supplied) The National Institute on Alcohol Abuse and Alcoholism has estimated that approximately 14 million people in the United States suffer from alcoholism. Alcohol sensitivity, the development of tolerance to alcohol and susceptibility to addiction vary in the population. Whereas environmental factors, such as stress and social experience, contribute to individual variation in sensitivity to chronic alcohol consumption, genetic factors have also been implicated. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2485

Platform:

GPL1322

15 Samples

Download data

Analysis of alcohol-sensitive Canton S animals immediately following ethanol exposure and a population of Canton S animals that developed tolerance 2 hours after ethanol exposure. Results provide insight into the underlying cellular and physiological mechanisms that respond to alcohol exposure.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 agent, 3 protocol, 2 strain sets

Platform:

GPL1322

Series:

GSE5382

15 Samples

Download data

(Submitter supplied) Genes relevant to manifestion of and variation in aggression behavior might be differentially expressed in lines selected for divergent levels of aggression. Keywords: selection group

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

24 Samples

Download data: CEL

(Submitter supplied) Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent and preventable pediatric disorder. Identifying genetic risk alleles for FASD is impossible in human populations, but the Drosophila genetic model can provide insights. We analyzed changes in genome-wide gene expression in 96 wild-derived inbred fly lines after exposure to alcohol during development. We found extensive sexual dimorphism in the effect of alcohol on gene expression along with effects on adult locomotor activity and sleep. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

384 Samples

Download data: TXT

(Submitter supplied) Genes relevant to manifestion of and variation in locomotor behavior might be differentially expressed in lines selected for divergent levels of locomotion. Keywords: selection group

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

24 Samples

Download data

(Submitter supplied) Transcriptional analysis for GEI in olfactory behavior Keywords: whole body, olfactory behavior

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

48 Samples

Download data: CEL, CHP

(Submitter supplied) We sequenced microRNA from heads of two D. melanogaster populations: an ethanol treated group (30 minutes after sedation with ethanol saturated vapor), and an age-matched untreated control group; and calculated differential microRNA expression between the two groups.

Organism:

Drosophila melanogaster

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL13304

2 Samples

Download data: TXT

(Submitter supplied) Outbred D.melanogaster populations subjected to >300 generations of natural selection on either control, or 12% ethanol, or variable food (2 replicates each) and exposed, as first instar larvae, to either water control or 12% ethanol.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

34 Samples

Download data: CEL, CHP

(Submitter supplied) We sequenced mRNA extracted from heads of a D. melanogaster population that was sedated with a stream of ethanol saturated vapor, 30 minutes before RNA extraction; and from an age-matched untreated control group. Differential gene expression between the two groups was calculated and reported.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13304

2 Samples

Download data: TXT

(Submitter supplied) Food consumption is critical for animal survival and reproduction. The biomedical and economic consequences of metabolic diseases arising from excessive food intake, however, are a burden for human society. While the role of neuroendocrine feedback loops, food sensing modalities, and physiological state in regulating food intake are increasingly well understood, other genetic mechanisms remain elusive. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

32 Samples

Download data: TXT

(Submitter supplied) Chloride intracellular channels (CLICs) are a unique family of evolutionarily conserved metamorphic proteins, switching between stable conformations based on redox conditions. CLICs have been implicated in a wide variety biological processes including ion channel activity, apoptosis, membrane trafficking, and enzymatic oxidoreductase activity. Understanding the molecular mechanisms by which CLICs engage in these activities is an area of active research. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL20842

15 Samples

Download data: CEL

(Submitter supplied) One of the critical substances that mammals highly regulate via the respiratory, cardiovascular and neurologic systems is O2. Both low and high O2 levels can induce major morbidities as well as mortality. Indeed, O2 has been often considered as both an elixir and a poison in humans. In current study, we have used an experimental selection approach to generate Drosophila strains that are tolerant to severe hyperoxic environment. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL1322

24 Samples

Download data: CEL

(Submitter supplied) Fetal alcohol exposure can lead to developmental abnormalities, intellectual disability, and behavioral changes, collectively termed fetal alcohol spectrum disorder (FASD). In 2015, the CDC found that 1 in 10 pregnant women report alcohol use and more than 3 million women in the USA are at risk of exposing their developing baby to alcohol. Identifying genetic risk alleles for FASD is challenging, since time, dose and frequency of exposure are often unknown, and phenotypic manifestations of FASD are diverse and become evident long after exposure. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25244

8 Samples

Download data: MTX, TSV

(Submitter supplied) Our objective was to determine whether gene expression in Drosophila melanogaster selectively bred for long or short night sleep duration changes detectably across generations. To meet this objective, we performed transcriptional profiling of ten pooled whole adult individuals from four selected populations and two control populations across 13 generations. We quantified differential expression among selection scheme (long sleep, short sleep, or unselected control), generation (generation 0; then generations 2-13), and sex for each gene.

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17275

312 Samples

Download data: CSV