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Links from GEO DataSets

Items: 6

1.
Full record GDS3077

Age-related aortic vasculopathy model

Analysis of thoracic aortas (TAs) of Fischer 344/Brown Norway F1 hybrids (F344xBN) at 3 to 28 months of age. Age is a risk factor for vascular disease. The TAs of F344xBN animals exhibit age-related pathologies. Results provide insight into the mechanisms underlying age-mediated vascular pathology.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 4 age sets
Platform:
GPL85
Series:
GSE7281
16 Samples
Download data: CEL, EXP
DataSet
Accession:
GDS3077
ID:
3077
2.

Development of Progressive Aortic Vasculopathy in a Rat Model of Aging

(Submitter supplied) This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk factor for vascular disease. Numerous changes occur in vascular structure and function during aging, and animal models, including rodents, are the primary means to determine the underlying mechanisms of age-mediated vascular pathology. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3077
Platform:
GPL85
16 Samples
Download data: CEL, EXP
Series
Accession:
GSE7281
ID:
200007281
3.

Raloxifene Attenuates Gas6 and Apoptosis in Experimental Aortic Valve Disease in Renal Failure

(Submitter supplied) Introduction: Renal failure is associated with aortic valve calcification. Using our rat model of uraemia-induced reversible aortic valve calcification, we assessed the role of apoptosis and survival pathways in aortic valve calcification. We also explored the effects of raloxifene - an estrogen receptor modulator on valvular calcification. Methods: Gene array analysis was performed in aortic valves obtained from 3 groups of rats (n=7 each): calcified valves from rats fed with uremic diet -high-adenine (0.75%), high-phosphate diet (1.5%), valves after calcification resolution following diet cessation (reversibility) and control. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL16305
4 Samples
Download data: GPR
Series
Accession:
GSE21771
ID:
200021771
4.

Inhibitory Role of Notch1 in Calcific Aortic Valve Disease

(Submitter supplied) Aortic valve calcification is the most common form of valvular heart disease, but the mechanisms of calcific aortic valve disease (CAVD) are unknown. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification in families with inherited disease. The Notch signaling pathway is critical for multiple cell differentiation processes, but its role in the development of CAVD is not well understood. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4488
Platform:
GPL1355
6 Samples
Download data: CEL
Series
Accession:
GSE31668
ID:
200031668
5.
Full record GDS4488

Notch1 signaling inhibition effect on aortic valve interstitial cells

Analysis of aortic valve interstitial cells treated with the Notch1 signaling inhibitor DAPT. NOTCH1 mutations are associated with aortic valve malformations and adult-onset calcification. Results provide insight into the role of Notch in the pathogenesis of calcific aortic valve disease.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL1355
Series:
GSE31668
6 Samples
Download data: CEL
6.

Increased Susceptibility of Aging Kidney to Ischemic Injury: Identification of Molecular Pathways using Microarray

(Submitter supplied) Aging is associated with an increased incidence and severity of acute renal failure. However, the molecular mechanism(s) underlying the increased susceptibility to injury remain undefined. These experiments were designed to investigate the influence of age on the response of the kidney to ischemic and nephrotoxic challenge. Renal slices were prepared from young (4 month), aged ad libitum (aged-AL; 24 month) and aged caloric restricted (aged-CR; 24 month) male Fischer 344 rats and subjected to ischemic stress (anoxia, 100% N2) for 0-60 min and to cisplatin (2 mM, 4hr) challenge. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL4478
12 Samples
Download data: XLS
Series
Accession:
GSE6110
ID:
200006110
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